<html><head><style type='text/css'>p { margin: 0; }</style></head><body><div style='font-family: times new roman,new york,times,serif; font-size: 12pt; color: #000000'>Dear, Carlos.<br><br>As we know, there is a higher production of IL-10 and IL-4 in a Th2 response, increasing the possibility of VL becoming symptomatic, due to inhibition of macrofages activation, allowing the intracellular replication of Leishmania. <br>In VL-HIV/AIDS coinfection, splenomegaly is less frequent, due to fail in macrophage proliferative response, clinical manifestaions are atypical and there are worse outcomes (more deaths and relapses).<br><span style="font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:Calibri;mso-ansi-language:PT-BR;mso-fareast-language:
EN-US;mso-bidi-language:AR-SA"> </span>If splenectomy would cure calazar is a doubt, because others organs from monophagocytic system might continue producting IL-10, <span id="result_box" class="short_text" lang="en"><span class="hps">perpetuating</span> <span class="hps">symptomatic infection.<br></span></span><br><span id="result_box" class="short_text" lang="en"><span class="hps">Respectfully</span></span>. <br>Hug´s!<br><br><div><span name="x"></span>Igor Thiago Borges de Queiroz e Silva<br>Infectologista do Hospital Giselda Trigueiro - SESAP - Natal/RN<br>Doutorando do Departamento de Doenças Infecciosas e Parasitárias - FMUSP<br>Laboratório de Soroepidemiologia (LIM38) - IMT/SP<br>igorthiago@usp.br<br>+55 (84) 9608-7999<span name="x"></span><br></div><br><hr id="zwchr"><blockquote style="border-left:2px solid rgb(16, 16, 255);margin-left:5px;padding-left:5px;color:#000;font-weight:normal;font-style:normal;text-decoration:none;font-family:Helvetica,Arial,sans-serif;font-size:12pt;"><b>De: </b>"Carlos Costa" <chncosta@gmail.com><br><b>Para: </b>"Leish-L" <Leish-l@lineu.icb.usp.br><br><b>Enviadas: </b>Quarta-feira, 21 de Agosto de 2013 9:52:54<br><b>Assunto: </b>[Leish-l] spleen<br><br><div dir="ltr"><div class="gmail_default" style="font-family:">Dear leishimmunologists,</div><div class="gmail_default" style="font-family:">
<br></div><div class="gmail_default" style="font-family:">Do you have any guess on why splenectomy cures kala-azar? Would it be the absence of spleen-derived IL-10?</div>
<div class="gmail_default" style="font-family:"><br></div><div class="gmail_default" style="font-family:">All my best,</div>
<div class="gmail_default" style="font-family:"><br></div><div class="gmail_default" style="font-family:">Carlos.</div>
<div><br></div>-- <br><div dir="ltr"><div style="text-align:left"><span style="font-family:verdana,sans-serif">Carlos H. N. Costa, MD, DSc.</span></div><div style="text-align:left"><span style="font-family:verdana,sans-serif">Coordenador</span></div>
<div style="text-align:left"><span style="font-family:verdana,sans-serif">Laboratório de Leishmanioses - LabLeish</span></div><div style="text-align:left"><span style="font-family:verdana,sans-serif">Universidade Federal do Piauí</span><br>
</div><div><div style="text-align:left"><span style="font-family:verdana,sans-serif">Instituto de Doenças Tropicais Natan Portella</span></div><div style="text-align:left"><font face="verdana, sans-serif">Rua Artur de Vasconcelos 151-Sul</font></div>
<div><div style="text-align:left"><span style="font-family:verdana,sans-serif">64001-450 Teresina-PI</span></div><font face="verdana, sans-serif"><div style="text-align:left">Brazil</div><div style="text-align:left">Telephones: +55 86 3222-4377 (W), <div style="text-align:center;display:inline!important">
<div style="text-align:center;display:inline!important">+55 86 3221-3062 (W), </div></div><div style="text-align:center;display:inline!important">+55 86 3237-1075 (R). </div></div><div style="text-align:left"><br></div><div style="text-align:left">
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