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<p>Dear Piero,</p>
<p> </p>
<p>I totaly agree with your evaluation; two basic and fundamental questions. As you know our TPP is an oral drug for complicated CL that works against all Leishmania species. I will gladly participate.</p>
<p> </p>
<p>V/r</p>
<p> </p>
<p>COL Max Grogl</p>
<p>Director, Division of Experimental Therapeutics</p>
<p>Walter Reed Army Institute of Research</p>
<p>Silver Spring, MD</p>
<p>202351876</p>
<p>3014909699</p>
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<div style="DIRECTION: ltr" id="divRpF578125"><font color="#000000" size="2" face="Tahoma"><b>From:</b> leish-l-bounces@lineu.icb.usp.br [leish-l-bounces@lineu.icb.usp.br] on behalf of OLLIARO, Piero Luigi [olliarop@who.int]<br>
<b>Sent:</b> Friday, March 29, 2013 8:49 PM<br>
<b>To:</b> Basanez, Maria-Gloria; 'Carlos Costa'; 'Leish-L'<br>
<b>Subject:</b> Re: [Leish-l] hot spots<br>
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<p class="MsoNormal"><span style="FONT-FAMILY: 'Calibri','sans-serif'; COLOR: #1f497d; FONT-SIZE: 11pt" lang="ES">María-Gloria :</span></p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Calibri','sans-serif'; COLOR: #1f497d; FONT-SIZE: 11pt" lang="ES">¿Quieres empezar una discusión sobre el desarrollo de las drogas?
</span></p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Calibri','sans-serif'; COLOR: #1f497d; FONT-SIZE: 11pt">Then I’d have my own list</span></p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Calibri','sans-serif'; COLOR: #1f497d; FONT-SIZE: 11pt"></span> </p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Calibri','sans-serif'; COLOR: #1f497d; FONT-SIZE: 11pt">But first and foremost: it is becoming VERY difficult today to convince decision makers to fund anti-leishmania drug R&D. So, one would have to start from
there: are new drugs needed? and which drugs? and we won’t have to preach to the converted (ourselves) but rather to the pagans. Shall we not start from there?</span></p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Calibri','sans-serif'; COLOR: #1f497d; FONT-SIZE: 11pt"></span> </p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Calibri','sans-serif'; COLOR: #1f497d; FONT-SIZE: 11pt">Meanwhile: !Felices pasquas!
</span></p>
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<p class="MsoNormal"><span style="FONT-FAMILY: 'Calibri','sans-serif'; COLOR: #1f497d; FONT-SIZE: 11pt">Piero</span></p>
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<p class="MsoNormal"><b><span style="FONT-FAMILY: 'Tahoma','sans-serif'; FONT-SIZE: 10pt" lang="EN-US">From:</span></b><span style="FONT-FAMILY: 'Tahoma','sans-serif'; FONT-SIZE: 10pt" lang="EN-US"> leish-l-bounces@lineu.icb.usp.br [mailto:leish-l-bounces@lineu.icb.usp.br]
<b>On Behalf Of </b>Basanez, Maria-Gloria<br>
<b>Sent:</b> 11 March 2013 16:24<br>
<b>To:</b> 'Carlos Costa'; 'Leish-L'<br>
<b>Subject:</b> Re: [Leish-l] hot spots</span></p>
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<p><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: black; FONT-SIZE: 10pt" lang="ES-TRAD">Not sure it's most polemic, but if you are thinking of collating and discussing a research & development agenda for leishmaniasis, I would like to add the updating
of mathematical transmission models, including multi-host systems, and the linking of such population dynamic models (rather than static ones) with analyses of economic evaluation for the cost-effectiveness analyses of interventions.</span></p>
<p><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: black; FONT-SIZE: 10pt" lang="ES-TRAD"></span> </p>
<p><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: black; FONT-SIZE: 10pt" lang="ES-TRAD">Best wishes to all,</span></p>
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<p><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: black; FONT-SIZE: 10pt" lang="ES-TRAD"></span> </p>
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<p class="MsoNormal"><span style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">Professor María-Gloria Basáñez MSc PhD FRES</span><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">
</span><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: black; FONT-SIZE: 10pt" lang="ES-TRAD"></span></p>
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<p class="MsoNormal"><span style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">Chair in Neglected Tropical Diseases</span><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: black; FONT-SIZE: 10pt" lang="ES-TRAD"></span></p>
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<p class="MsoNormal"><span style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">School of Public Health</span><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD"> <br>
</span><span style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">Department of Infectious Disease Epidemiology</span><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">
<br>
</span><span style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">Faculty of Medicine (St Mary's campus)</span><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">
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</span><span style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">Imperial College London</span><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">
<br>
</span><span style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">Norfolk Place, London W2 1PG, UK</span><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">
</span><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: black; FONT-SIZE: 10pt" lang="ES-TRAD"></span></p>
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<p class="MsoNormal"><span style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">Tel: + 44 0(20) 75943295</span><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">
<br>
</span><span style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">Fax: +44 0(20) 74023927</span><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">
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</span><span style="FONT-FAMILY: 'Arial','sans-serif'; COLOR: gray; FONT-SIZE: 10pt" lang="ES-TRAD">E-mail:
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<p class="MsoNormal"><b><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: black; FONT-SIZE: 10pt" lang="ES">De:</span></b><span style="FONT-FAMILY: 'Tahoma','sans-serif'; COLOR: black; FONT-SIZE: 10pt" lang="ES">
<a href="https://web-mech.mail.mil/owa/UrlBlockedError.aspx" target="_blank">leish-l-bounces@lineu.icb.usp.br</a> [<a href="https://web-mech.mail.mil/owa/UrlBlockedError.aspx" target="_blank">mailto:leish-l-bounces@lineu.icb.usp.br</a>]
<b>En nombre de </b>Carlos Costa<br>
<b>Enviado el:</b> jueves, 07 de febrero de 2013 8:39<br>
<b>Para:</b> Leish-L<br>
<b>Asunto:</b> [Leish-l] hot spots</span><span style="COLOR: black" lang="ES-TRAD"></span></p>
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<p class="MsoNormal"><span style="COLOR: black" lang="ES-TRAD"></span> </p>
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<p class="MsoNormal"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: black" lang="ES-TRAD">What are the most polemic issues in leishmaniasis?<br clear="all">
</span><span style="COLOR: black" lang="ES-TRAD"></span></p>
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<p class="MsoNormal"><span style="COLOR: black" lang="ES-TRAD"></span> </p>
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<p class="MsoNormal"><span style="COLOR: black" lang="ES-TRAD">-- </span></p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: black" lang="ES-TRAD">Carlos H. N. Costa, MD, DSc.</span><span style="COLOR: black" lang="ES-TRAD"></span></p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: black" lang="ES-TRAD">Sociedade Brasileira de Medicina Tropical </span><span style="COLOR: black" lang="ES-TRAD"></span></p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: black" lang="ES-TRAD">(Brazilian Society of Tropical Medicine)</span><span style="COLOR: black" lang="ES-TRAD"></span></p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: black" lang="ES-TRAD">President</span><span style="COLOR: black" lang="ES-TRAD"></span></p>
<p class="MsoNormal"><span style="COLOR: black" lang="ES-TRAD"></span> </p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: black" lang="ES-TRAD">Universidade Federal do Piauí</span><span style="COLOR: black" lang="ES-TRAD"></span></p>
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<p class="MsoNormal"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: black" lang="ES-TRAD">Instituto de Doenças Tropicais Natan Portella</span><span style="COLOR: black" lang="ES-TRAD"></span></p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: black" lang="ES-TRAD">Rua Artur de Vasconcelos 151-Sul</span><span style="COLOR: black" lang="ES-TRAD"></span></p>
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<p class="MsoNormal"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: black" lang="ES-TRAD">64001-450 Teresina-PI</span><span style="COLOR: black" lang="ES-TRAD"></span></p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: black" lang="ES-TRAD">Brazil</span><span style="COLOR: black" lang="ES-TRAD"></span></p>
<p class="MsoNormal"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: black" lang="ES-TRAD">Telephones: +55 86 3222-4377 (W), </span><span style="COLOR: black" lang="ES-TRAD"></span></p>
<p style="TEXT-ALIGN: center" class="MsoNormal" align="center"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: black" lang="ES-TRAD">+55 86 3221-3062 (W), </span><span style="COLOR: black" lang="ES-TRAD"></span></p>
<p style="TEXT-ALIGN: center" class="MsoNormal" align="center"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: black" lang="ES-TRAD">+55 86 3237-1075 (R). </span><span style="COLOR: black" lang="ES-TRAD"></span></p>
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