<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1">
<meta name="Generator" content="Microsoft Word 14 (filtered medium)">
<style><!--
/* Font Definitions */
@font-face
        {font-family:Wingdings;
        panose-1:5 0 0 0 0 0 0 0 0 0;}
@font-face
        {font-family:Wingdings;
        panose-1:5 0 0 0 0 0 0 0 0 0;}
@font-face
        {font-family:Calibri;
        panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
        {font-family:Tahoma;
        panose-1:2 11 6 4 3 5 4 4 2 4;}
@font-face
        {font-family:Consolas;
        panose-1:2 11 6 9 2 2 4 3 2 4;}
@font-face
        {font-family:Verdana;
        panose-1:2 11 6 4 3 5 4 4 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
        {margin:0in;
        margin-bottom:.0001pt;
        font-size:12.0pt;
        font-family:"Times New Roman","serif";}
a:link, span.MsoHyperlink
        {mso-style-priority:99;
        color:blue;
        text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
        {mso-style-priority:99;
        color:purple;
        text-decoration:underline;}
pre
        {mso-style-priority:99;
        mso-style-link:"HTML Preformatted Char";
        margin:0in;
        margin-bottom:.0001pt;
        font-size:10.0pt;
        font-family:"Courier New";}
p.MsoAcetate, li.MsoAcetate, div.MsoAcetate
        {mso-style-priority:99;
        mso-style-link:"Balloon Text Char";
        margin:0in;
        margin-bottom:.0001pt;
        font-size:8.0pt;
        font-family:"Tahoma","sans-serif";}
p.MsoListParagraph, li.MsoListParagraph, div.MsoListParagraph
        {mso-style-priority:34;
        margin-top:0in;
        margin-right:0in;
        margin-bottom:0in;
        margin-left:.5in;
        margin-bottom:.0001pt;
        font-size:12.0pt;
        font-family:"Times New Roman","serif";}
span.HTMLPreformattedChar
        {mso-style-name:"HTML Preformatted Char";
        mso-style-priority:99;
        mso-style-link:"HTML Preformatted";
        font-family:Consolas;}
span.BalloonTextChar
        {mso-style-name:"Balloon Text Char";
        mso-style-priority:99;
        mso-style-link:"Balloon Text";
        font-family:"Tahoma","sans-serif";}
span.EmailStyle22
        {mso-style-type:personal;
        font-family:"Calibri","sans-serif";
        color:#1F497D;}
span.EmailStyle23
        {mso-style-type:personal;
        font-family:"Calibri","sans-serif";
        color:#1F497D;}
span.EmailStyle24
        {mso-style-type:personal-reply;
        font-family:"Calibri","sans-serif";
        color:#1F497D;}
.MsoChpDefault
        {mso-style-type:export-only;
        font-size:10.0pt;}
@page WordSection1
        {size:8.5in 11.0in;
        margin:70.85pt 85.05pt 70.85pt 85.05pt;}
div.WordSection1
        {page:WordSection1;}
/* List Definitions */
@list l0
        {mso-list-id:1826899768;
        mso-list-type:hybrid;
        mso-list-template-ids:1040480274 7743204 201981955 201981957 201981953 201981955 201981957 201981953 201981955 201981957;}
@list l0:level1
        {mso-level-start-at:0;
        mso-level-number-format:bullet;
        mso-level-text:-;
        mso-level-tab-stop:none;
        mso-level-number-position:left;
        text-indent:-.25in;
        font-family:"Calibri","sans-serif";
        mso-fareast-font-family:Calibri;}
@list l0:level2
        {mso-level-number-format:bullet;
        mso-level-text:o;
        mso-level-tab-stop:none;
        mso-level-number-position:left;
        text-indent:-.25in;
        font-family:"Courier New";}
@list l0:level3
        {mso-level-number-format:bullet;
        mso-level-text:\F0A7;
        mso-level-tab-stop:none;
        mso-level-number-position:left;
        text-indent:-.25in;
        font-family:Wingdings;}
@list l0:level4
        {mso-level-number-format:bullet;
        mso-level-text:\F0B7;
        mso-level-tab-stop:none;
        mso-level-number-position:left;
        text-indent:-.25in;
        font-family:Symbol;}
@list l0:level5
        {mso-level-number-format:bullet;
        mso-level-text:o;
        mso-level-tab-stop:none;
        mso-level-number-position:left;
        text-indent:-.25in;
        font-family:"Courier New";}
@list l0:level6
        {mso-level-number-format:bullet;
        mso-level-text:\F0A7;
        mso-level-tab-stop:none;
        mso-level-number-position:left;
        text-indent:-.25in;
        font-family:Wingdings;}
@list l0:level7
        {mso-level-number-format:bullet;
        mso-level-text:\F0B7;
        mso-level-tab-stop:none;
        mso-level-number-position:left;
        text-indent:-.25in;
        font-family:Symbol;}
@list l0:level8
        {mso-level-number-format:bullet;
        mso-level-text:o;
        mso-level-tab-stop:none;
        mso-level-number-position:left;
        text-indent:-.25in;
        font-family:"Courier New";}
@list l0:level9
        {mso-level-number-format:bullet;
        mso-level-text:\F0A7;
        mso-level-tab-stop:none;
        mso-level-number-position:left;
        text-indent:-.25in;
        font-family:Wingdings;}
ol
        {margin-bottom:0in;}
ul
        {margin-bottom:0in;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="EN-US" link="blue" vlink="purple">
<div class="WordSection1">
<p class="MsoNormal"><span lang="FR-CH">Can you please take me off this mailing list ?
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="FR-CH">Thank you,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="FR-CH">Cristina</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<div>
<div style="border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in">
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">From:</span></b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif""> Farrokh Modabber [mailto:fmodabber@dndi.org]
<br>
<b>Sent:</b> Monday, February 11, 2013 7:38 PM<br>
<b>To:</b> 'Carlos Costa'; 'Leish-L'<br>
<b>Subject:</b> [Leish-l] What are the most polemic issues in leishmaniasis?<o:p></o:p></span></p>
</div>
</div>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Dear Carlos,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">I think
<i>Leishmania</i> classification should be updated. I have problem with identification of
<i>Leishmania</i> isolates based on non-biological markers. The ones used, i.e. genetic markers (not associated with known biological activity), iso-enzymes electrophoresis (all the isoenzymes have the same biological activity and changes somewhere in the
enzyme molecule cause different electrophoretic migration). Now that we know conjugation (transfer of genetic material from one to another
<i>Leishmania</i>) occur, and with the whole genome sequencing available, isn’t it time to look for biological markers? The tools used, have helped us establish the evolutionary trees but do not help us in knowing what kind of disease each isolate will produce,
their vector specificity, etc. I realize that disease outcome also depends on host response, but still some better markers may be identified.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">What do you think?<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">All the best,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Farrokh <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<div>
<div style="border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in">
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">From:</span></b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">
<a href="mailto:leish-l-bounces@lineu.icb.usp.br">leish-l-bounces@lineu.icb.usp.br</a> [<a href="mailto:leish-l-bounces@lineu.icb.usp.br">mailto:leish-l-bounces@lineu.icb.usp.br</a>]
<b>On Behalf Of </b>Israel Cruz Mata<br>
<b>Sent:</b> lundi 11 février 2013 09:46<br>
<b>To:</b> 'Carlos Costa'; 'Leish-L'<br>
<b>Subject:</b> Re: [Leish-l] hot spots<o:p></o:p></span></p>
</div>
</div>
<p class="MsoNormal"><span lang="FR-CH"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Hi Carlos,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">I´m curious about these:<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoListParagraph" style="text-indent:-.25in;mso-list:l0 level1 lfo2"><![if !supportLists]><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">“Leishmania siamensis”: causing dermal and visceral human leishmaniasis in Thailand, cutaneous equine and bovine leishmaniasis in central Europe,
and equine cutaneous leishmanaisis in USA.<o:p></o:p></span></p>
<p class="MsoListParagraph"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Is it really the same parasite in all cases, it is a new Leishmania specie emerging worldwide?<o:p></o:p></span></p>
<p class="MsoListParagraph"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoListParagraph" style="text-indent:-.25in;mso-list:l0 level1 lfo2"><![if !supportLists]><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Leishmania in Macropods and its transmission by midges (Ceratopogonidae), not sandflies.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:.25in"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoListParagraph" style="text-indent:-.25in;mso-list:l0 level1 lfo2"><![if !supportLists]><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Control strategies for ZVL in South America: alternatives for dog culling.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">All the best,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Isra<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="ES" style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">De:</span></b><span lang="ES" style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">
<a href="mailto:leish-l-bounces@lineu.icb.usp.br">leish-l-bounces@lineu.icb.usp.br</a> [<a href="mailto:leish-l-bounces@lineu.icb.usp.br">mailto:leish-l-bounces@lineu.icb.usp.br</a>]
<b>En nombre de </b>Carlos Costa<br>
<b>Enviado el:</b> jueves, 07 de febrero de 2013 20:39<br>
<b>Para:</b> Leish-L<br>
<b>Asunto:</b> [Leish-l] hot spots<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES"><o:p> </o:p></span></p>
<div>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif";color:black">What are the most polemic issues in leishmaniasis?<br clear="all">
</span><span lang="ES"><o:p></o:p></span></p>
<div>
<p class="MsoNormal"><span lang="ES"><o:p> </o:p></span></p>
</div>
<p class="MsoNormal"><span lang="ES">-- <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Carlos H. N. Costa, MD, DSc.</span><span lang="ES"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Sociedade Brasileira de Medicina Tropical </span><span lang="ES"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">(Brazilian Society of Tropical Medicine)</span><span lang="ES"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">President</span><span lang="ES"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Universidade Federal do Piauí</span><span lang="ES"><o:p></o:p></span></p>
<div>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Instituto de Doenças Tropicais Natan Portella</span><span lang="ES"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Rua Artur de Vasconcelos 151-Sul</span><span lang="ES"><o:p></o:p></span></p>
<div>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">64001-450 Teresina-PI</span><span lang="ES"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Brazil<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Telephones: +55 86 3222-4377 (W), <o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="ES" style="font-family:"Verdana","sans-serif"">+55 86 3221-3062 (W), <o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="ES" style="font-family:"Verdana","sans-serif"">+55 86 3237-1075 (R). <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-size:10.0pt;font-family:"Verdana","sans-serif"">Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas pelo sigilo legal, por direitos autorais e destinadas exclusivamente à pessoa ou organização
para a qual a mensagem foi destinada.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-size:10.0pt;font-family:"Verdana","sans-serif"">Warning: This message is meant only for the intended recipient of the transmission. It is forbidden any unauthorized use, alteration, reproduction and distribution.
If you are not the correct recipient, please notify us immediately by return e-mail and delete this message from your system.<o:p></o:p></span></p>
</div>
</div>
</div>
<table class="MsoNormalTable" border="0" cellpadding="0">
<tbody>
<tr>
<td style="background:white;padding:.75pt .75pt .75pt .75pt">
<pre><span style="color:black">************************* AVISO LEGAL *************************<o:p></o:p></span></pre>
<pre><span style="color:black">Este mensaje electrónico está dirigido exclusivamente a sus destinatarios,<o:p></o:p></span></pre>
<pre><span style="color:black">pudiendo contener documentos anexos de carácter privado y confidencial.<o:p></o:p></span></pre>
<pre><span style="color:black">Si por error, ha recibido este mensaje y no se encuentra entre los<o:p></o:p></span></pre>
<pre><span style="color:black">destinatarios, por favor, no use, informe, distribuya, imprima o copie su<o:p></o:p></span></pre>
<pre><span style="color:black">contenido por ningún medio. Le rogamos lo comunique al remitente y borre<o:p></o:p></span></pre>
<pre><span style="color:black">completamente el mensaje y sus anexos. El Instituto de Salud Carlos III no<o:p></o:p></span></pre>
<pre><span style="color:black">asume ningún tipo de responsabilidad legal por el contenido de este mensaje<o:p></o:p></span></pre>
<pre><span style="color:black">cuando no responda a las funciones atribuidas al remitente del mismo por la<o:p></o:p></span></pre>
<pre><span style="color:black">normativa vigente.<o:p></o:p></span></pre>
</td>
</tr>
</tbody>
</table>
<p class="MsoNormal"><span lang="FR-CH"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="FR-CH"><br>
<br>
--<br>
<i>This email was sent by icb.usp.br </i> <o:p></o:p></span></p>
</div>
</body>
</html>