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<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Dear Carlos,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">I think
<i>Leishmania</i> classification should be updated. I have problem with identification of
<i>Leishmania</i> isolates based on non-biological markers. The ones used, i.e. genetic markers (not associated with known biological activity), iso-enzymes electrophoresis (all the isoenzymes have the same biological activity and changes somewhere in the
enzyme molecule cause different electrophoretic migration). Now that we know conjugation (transfer of genetic material from one to another
<i>Leishmania</i>) occur, and with the whole genome sequencing available, isn’t it time to look for biological markers? The tools used, have helped us establish the evolutionary trees but do not help us in knowing what kind of disease each isolate will produce,
their vector specificity, etc. I realize that disease outcome also depends on host response, but still some better markers may be identified.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">What do you think?<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">All the best,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Farrokh <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
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<p class="MsoNormal"><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">From:</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Tahoma","sans-serif""> leish-l-bounces@lineu.icb.usp.br [mailto:leish-l-bounces@lineu.icb.usp.br]
<b>On Behalf Of </b>Israel Cruz Mata<br>
<b>Sent:</b> lundi 11 février 2013 09:46<br>
<b>To:</b> 'Carlos Costa'; 'Leish-L'<br>
<b>Subject:</b> Re: [Leish-l] hot spots<o:p></o:p></span></p>
</div>
</div>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span lang="ES" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Hi Carlos,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">I´m curious about these:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoListParagraph" style="text-indent:-18.0pt;mso-list:l0 level1 lfo2"><![if !supportLists]><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">“Leishmania siamensis”: causing dermal and visceral human leishmaniasis in Thailand, cutaneous equine and bovine leishmaniasis in central
Europe, and equine cutaneous leishmanaisis in USA.<o:p></o:p></span></p>
<p class="MsoListParagraph"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Is it really the same parasite in all cases, it is a new Leishmania specie emerging worldwide?<o:p></o:p></span></p>
<p class="MsoListParagraph"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoListParagraph" style="text-indent:-18.0pt;mso-list:l0 level1 lfo2"><![if !supportLists]><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Leishmania in Macropods and its transmission by midges (Ceratopogonidae), not sandflies.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:18.0pt"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoListParagraph" style="text-indent:-18.0pt;mso-list:l0 level1 lfo2"><![if !supportLists]><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Control strategies for ZVL in South America: alternatives for dog culling.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">All the best,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Isra<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="ES" style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">De:</span></b><span lang="ES" style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">
<a href="mailto:leish-l-bounces@lineu.icb.usp.br">leish-l-bounces@lineu.icb.usp.br</a> [<a href="mailto:leish-l-bounces@lineu.icb.usp.br">mailto:leish-l-bounces@lineu.icb.usp.br</a>]
<b>En nombre de </b>Carlos Costa<br>
<b>Enviado el:</b> jueves, 07 de febrero de 2013 20:39<br>
<b>Para:</b> Leish-L<br>
<b>Asunto:</b> [Leish-l] hot spots<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES"><o:p> </o:p></span></p>
<div>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif";color:black">What are the most polemic issues in leishmaniasis?<br clear="all">
</span><span lang="ES"><o:p></o:p></span></p>
<div>
<p class="MsoNormal"><span lang="ES"><o:p> </o:p></span></p>
</div>
<p class="MsoNormal"><span lang="ES">-- <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Carlos H. N. Costa, MD, DSc.</span><span lang="ES"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Sociedade Brasileira de Medicina Tropical </span><span lang="ES"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">(Brazilian Society of Tropical Medicine)</span><span lang="ES"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">President</span><span lang="ES"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Universidade Federal do Piauí</span><span lang="ES"><o:p></o:p></span></p>
<div>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Instituto de Doenças Tropicais Natan Portella</span><span lang="ES"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Rua Artur de Vasconcelos 151-Sul</span><span lang="ES"><o:p></o:p></span></p>
<div>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">64001-450 Teresina-PI</span><span lang="ES"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Brazil<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif"">Telephones: +55 86 3222-4377 (W), <o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="ES" style="font-family:"Verdana","sans-serif"">+55 86 3221-3062 (W), <o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="ES" style="font-family:"Verdana","sans-serif"">+55 86 3237-1075 (R). <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-size:10.0pt;font-family:"Verdana","sans-serif"">Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas pelo sigilo legal, por direitos autorais e destinadas exclusivamente à pessoa ou organização
para a qual a mensagem foi destinada.<o:p></o:p></span></p>
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If you are not the correct recipient, please notify us immediately by return e-mail and delete this message from your system.<o:p></o:p></span></p>
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<pre><span style="color:black">************************* AVISO LEGAL *************************<o:p></o:p></span></pre>
<pre><span style="color:black">Este mensaje electrónico está dirigido exclusivamente a sus destinatarios,<o:p></o:p></span></pre>
<pre><span style="color:black">pudiendo contener documentos anexos de carácter privado y confidencial.<o:p></o:p></span></pre>
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<pre><span style="color:black">contenido por ningún medio. Le rogamos lo comunique al remitente y borre<o:p></o:p></span></pre>
<pre><span style="color:black">completamente el mensaje y sus anexos. El Instituto de Salud Carlos III no<o:p></o:p></span></pre>
<pre><span style="color:black">asume ningún tipo de responsabilidad legal por el contenido de este mensaje<o:p></o:p></span></pre>
<pre><span style="color:black">cuando no responda a las funciones atribuidas al remitente del mismo por la<o:p></o:p></span></pre>
<pre><span style="color:black">normativa vigente.<o:p></o:p></span></pre>
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