<html><body><span style="font-family:Verdana; color:#000000; font-size:10pt;"><div>Dear Dr Satoskar and Dr Chang,</div><div>We are happy to lend any equipment to treat in Panama. We currently do not have any equipment there but will work with any physicians that are interested in utilizing the equipment. If there is a university or NGO that we could work with getting the equipment into the country through a charitable donation that would assist in dealing with customs.</div><div><br></div><div>My cell phone is 602-284-1489 I can be reached at any time to accommodate time differences.</div><div><br></div><div>Gena <br></div><div><br></div><div>Gena Zischke<br>Business Development<br>Thermosurgery Technologies, Inc.<br>2901 W. Indian School Rd.<br>Phoenix, AZ 85017<br>Phone: (602) 264-7300<br><br><br>The information in this communication is confidential. It is intended solely for the addressee. Access to this communication by anyone else is unauthorized. If you are not the intended recipient, any disclosure, copying, distribution or any action taken or omitted to be taken in reliance on it, is prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return email, and destroy this communication and all copies thereof, including all attachments. Thank you. Thermosurgery Technologies, Inc.<br><br><br>Fax: (602) 248-3809<br><br></div>
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-------- Original Message --------<br>
Subject: RE: [Leish-l] miltefosine for diffuse leishmaniasis<br>
From: "Chang, Kwang-Poo" <<a href="http://KwangPoo.Chang@rosalindfranklin.edu">KwangPoo.Chang@rosalindfranklin.edu</a>><br>
Date: Tue, July 26, 2011 7:42 am<br>
To: "Satoskar, Abhay" <<a href="http://Abhay.Satoskar@osumc.edu">Abhay.Satoskar@osumc.edu</a>>, Carlos Costa<br>
<<a href="mailto:chncosta@gmail.com">chncosta@gmail.com</a>><br>
Cc: <<a href="mailto:gzischke@thermosurgery.com">gzischke@thermosurgery.com</a>>, John David <<a href="mailto:jdavid@hsph.harvard.edu">jdavid@hsph.harvard.edu</a>>,<br>
<<a href="mailto:generhedin@thermosurgery.com">generhedin@thermosurgery.com</a>>, Josh Berman <<a href="mailto:Jbe9320457@aol.com">Jbe9320457@aol.com</a>>,<br>
<<a href="mailto:dagobertosilveira@superig.com.br">dagobertosilveira@superig.com.br</a>>, Raimunda Sampaio <<a href="mailto:rsampaio@unb.br">rsampaio@unb.br</a>>,<br>
Dorcas Lamounier Costa <<a href="http://dorcas.lc@gmail.com">dorcas.lc@gmail.com</a>>, Mark Nawacki<br>
<<a href="mailto:mnawacki@paladinlabs.com">mnawacki@paladinlabs.com</a>>, <<a href="mailto:jurbina@mac.com">jurbina@mac.com</a>>, Pierre BUFFET<br>
<<a href="mailto:pierre.buffet@upmc.fr">pierre.buffet@upmc.fr</a>>, <<a href="mailto:joseanegodinho@yahoo.com.br">joseanegodinho@yahoo.com.br</a>>, Robert Vinson<br>
<<a href="mailto:rvinson@paladinlabs.com">rvinson@paladinlabs.com</a>>, Shyam Sundarmail <<a href="mailto:Drshyamsundar@hotmail.com">Drshyamsundar@hotmail.com</a>>,<br>
<<a href="mailto:robertobadaro768@gmail.com">robertobadaro768@gmail.com</a>>, Leish-L <<a href="mailto:Leish-l@lineu.icb.usp.br">Leish-l@lineu.icb.usp.br</a>>,<br>
Fernando Koremblum <<a href="mailto:fkorembl@paladinlabs.com">fkorembl@paladinlabs.com</a>>, Fabiana Alves<br>
<<a href="mailto:falves@dndi.org">falves@dndi.org</a>>, Fabiana Alves <<a href="mailto:fabipalves@gmail.com">fabipalves@gmail.com</a>><br>
<br>
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</style> <div class="Section1"> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;">Dear Abhay,<o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;"><o:p> </o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;">Do you know someone in <st1:country-region w:st="on"><st1:place w:st="on">Panama</st1:place></st1:country-region> who has the RFH equipment to carry out the heat treatment ? I do believe in it and said so in my previous messages.<o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;"><o:p> </o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;">KP<o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;"><o:p> </o:p></span></font></div> <div> <div class="MsoNormal" style="font-size:12pt;text-align: center;" align="center"><font face="Times New Roman" size="3"><span style="font-size: 12pt;"> <hr tabindex="-1" align="center" size="2" width="100%"> </span></font></div> <div class="MsoNormal" style="font-size:12pt;"><b><font face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; font-weight: bold;">From:</span></font></b><font face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma;"> Satoskar, Abhay [mailto:<a href="http://Abhay.Satoskar@osumc.edu">Abhay.Satoskar@osumc.edu</a>] <br> <b><span style="font-weight: bold;">Sent:</span></b> Tuesday, July 26, 2011 5:35 AM<br> <b><span style="font-weight: bold;">To:</span></b> Chang, Kwang-Poo; <st1:personname w:st="on">Carlos Costa</st1:personname><br> <b><span style="font-weight: bold;">Cc:</span></b> <a href="mailto:gzischke@thermosurgery.com">gzischke@thermosurgery.com</a>; John David; <a href="mailto:generhedin@thermosurgery.com">generhedin@thermosurgery.com</a>; Josh Berman; <a href="mailto:dagobertosilveira@superig.com.br">dagobertosilveira@superig.com.br</a>; Raimunda Sampaio; Dorcas Lamounier Costa; Mark Nawacki; <a href="mailto:jurbina@mac.com">jurbina@mac.com</a>; Pierre BUFFET; <a href="mailto:joseanegodinho@yahoo.com.br">joseanegodinho@yahoo.com.br</a>; Robert Vinson; Shyam Sundarmail; <a href="mailto:robertobadaro768@gmail.com">robertobadaro768@gmail.com</a>; Leish-L; Fernando Koremblum; Fabiana Alves; Fabiana Alves<br> <b><span style="font-weight: bold;">Subject:</span></b> RE: [Leish-l] miltefosine for diffuse leishmaniasis</span></font><o:p></o:p></div> </div> <div class="MsoNormal" style="font-size:12pt;"><font face="Times New Roman" size="3"><span style="font-size: 12pt;"><o:p> </o:p></span></font></div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">KP<o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">My suggestion would be RFH treatment<o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">of intralesional antimony twice a week upto 6 doses<o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">This works in L.tropica CL<o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">abhay<o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;"> <o:p></o:p></span></font></div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">Abhay R Satoskar MD, PhD<o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">Professor<o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">Departments of Pathology and Microbiology<o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">129 <st1:city w:st="on"><st1:place w:st="on">Hamilton</st1:place></st1:city> Hall<o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><st1:street w:st="on"><st1:address w:st="on"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">1645 Neil Avenue</span></font></st1:address></st1:street><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">The <st1:place w:st="on"><st1:placename w:st="on">Ohio</st1:placename> <st1:placetype w:st="on">State</st1:placetype> <st1:placetype w:st="on">University</st1:placetype></st1:place><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><st1:place w:st="on"><st1:city w:st="on"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">Columbus</span></font></st1:city><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">, <st1:state w:st="on">Ohio</st1:state></span></font></st1:place><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;">Tel: 614-366-3417<o:p></o:p></span></font></div> </div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;"> <o:p></o:p></span></font></div> </div> <div id="divRpF61649"> <div class="MsoNormal" style="font-size:12pt;text-align: center;" align="center"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;"> <hr tabindex="-1" align="center" size="2" width="100%"> </span></font></div> <div class="MsoNormal" style="font-size:12pt;margin-bottom: 12pt;"><b><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black; font-weight: bold;">From:</span></font></b><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;"> Chang, Kwang-Poo [<a href="http://KwangPoo.Chang@rosalindfranklin.edu">KwangPoo.Chang@rosalindfranklin.edu</a>]<br> <b><span style="font-weight: bold;">Sent:</span></b> Monday, July 25, 2011 2:58 PM<br> <b><span style="font-weight: bold;">To:</span></b> <st1:personname w:st="on">Carlos Costa</st1:personname><br> <b><span style="font-weight: bold;">Cc:</span></b> <a href="mailto:gzischke@thermosurgery.com">gzischke@thermosurgery.com</a>; Satoskar, Abhay; John David; <a href="mailto:generhedin@thermosurgery.com">generhedin@thermosurgery.com</a>; Josh Berman; <a href="mailto:dagobertosilveira@superig.com.br">dagobertosilveira@superig.com.br</a>; Raimunda Sampaio; Dorcas Lamounier Costa; Mark Nawacki; <a href="mailto:jurbina@mac.com">jurbina@mac.com</a>; Pierre BUFFET; <a href="mailto:joseanegodinho@yahoo.com.br">joseanegodinho@yahoo.com.br</a>; Robert Vinson; Shyam Sundarmail; <a href="mailto:robertobadaro768@gmail.com">robertobadaro768@gmail.com</a>; Leish-L; Fernando Koremblum; Fabiana Alves; Fabiana Alves<br> <b><span style="font-weight: bold;">Subject:</span></b> RE: [Leish-l] miltefosine for diffuse leishmaniasis<o:p></o:p></span></font></div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;">I am writing to ask for your help with information and suggestion about treating cutaneous leishmaniasis in <st1:country-region w:st="on"><st1:place w:st="on">Panama</st1:place></st1:country-region>.</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;">I have only very sketchy information about the case as follows:</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> <ol style="margin-top: 0pt;" start="1" type="1"> <li class="MsoNormal" style="color: navy;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial;">An American young man has 2 skin lesions, one of which is on the abdomen. </span></font><o:p></o:p></li> <li class="MsoNormal" style="color: navy;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial;">He was diagnosed to have cutaneous leishmaniasis</span></font> <o:p></o:p></li> <li class="MsoNormal" style="color: navy;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial;">A course of 30-day intra-muscular injection of pentavalent antimony is prescribed.</span></font> <o:p></o:p></li> </ol> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;">I wonder about the intramuscular instead of intra-lesion antimony treatment and also the duration of the treatment for 30 days ?</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;">Looking forward to hearing from you at your earliest convenience.</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;">KP</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> <div> <div class="MsoNormal" style="font-size:12pt;text-align: center;" align="center"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <hr tabindex="-1" align="center" size="2" width="100%"> </span></font></div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black; font-weight: bold;">From:</span></font></b><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;"> <st1:personname w:st="on">Carlos Costa</st1:personname> [<a href="mailto:chncosta@gmail.com">mailto:chncosta@gmail.com</a>] <br> <b><span style="font-weight: bold;">Sent:</span></b> Tuesday, July 12, 2011 2:46 PM<br> <b><span style="font-weight: bold;">To:</span></b> Chang, Kwang-Poo<br> <b><span style="font-weight: bold;">Cc:</span></b> <a href="mailto:gzischke@thermosurgery.com">gzischke@thermosurgery.com</a>; Abhay Satoskar; John David; <a href="mailto:generhedin@thermosurgery.com">generhedin@thermosurgery.com</a>; Josh Berman; <a href="mailto:dagobertosilveira@superig.com.br">dagobertosilveira@superig.com.br</a>; Raimunda Sampaio; Dorcas Lamounier Costa; Mark Nawacki; <a href="mailto:jurbina@mac.com">jurbina@mac.com</a>; Pierre BUFFET; <a href="mailto:joseanegodinho@yahoo.com.br">joseanegodinho@yahoo.com.br</a>; Robert Vinson; Shyam Sundarmail; <a href="mailto:robertobadaro768@gmail.com">robertobadaro768@gmail.com</a>; Leish-L; Fernando Koremblum; Fabiana Alves; Fabiana Alves<br> <b><span style="font-weight: bold;">Subject:</span></b> Re: [Leish-l] miltefosine for diffuse leishmaniasis</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="4"><span style="font-size: 13.5pt; font-family: Verdana; color: black;">Hi Gena,</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="4"><span style="font-size: 13.5pt; font-family: Verdana; color: black;">Thanks a lot for your offer. </span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="4"><span style="font-size: 13.5pt; font-family: Verdana; color: black;">Our purpose is to work together with John and Abhay, who I know personally for a long time. May be the experience here will lead to broader application.</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="4"><span style="font-size: 13.5pt; font-family: Verdana; color: black;">I am forwarding your email to DNDi to see if they could help us in getting the machine into the country, since they have expertise in this kind of humanitarian treatment.</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="4"><span style="font-size: 13.5pt; font-family: Verdana; color: black;">My best regards,</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="4"><span style="font-size: 13.5pt; font-family: Verdana; color: black;">Carlos. </span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;">2011/7/12 Chang, Kwang-Poo <<a target="_blank" href="mailto:KwangPoo.Chang@rosalindfranklin.edu">KwangPoo.Chang@rosalindfranklin.edu</a>><o:p></o:p></span></font></div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;">This is good to try.</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;">KP</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> <div> <div class="MsoNormal" style="font-size:12pt;text-align: center;" align="center"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <hr align="center" size="2" width="100%"> </span></font></div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black; font-weight: bold;">From:</span></font></b><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;"> <a target="_blank" href="mailto:gzischke@thermosurgery.com">gzischke@thermosurgery.com</a> [mailto:<a target="_blank" href="mailto:gzischke@thermosurgery.com">gzischke@thermosurgery.com</a>] <br> <b><span style="font-weight: bold;">Sent:</span></b> Tuesday, July 12, 2011 12:47 PM<br> <b><span style="font-weight: bold;">To:</span></b> <st1:personname w:st="on">Carlos Costa</st1:personname>; Abhay Satoskar; John David; <a target="_blank" href="mailto:generhedin@thermosurgery.com">generhedin@thermosurgery.com</a><br> <b><span style="font-weight: bold;">Cc:</span></b> Josh Berman; <a target="_blank" href="mailto:dagobertosilveira@superig.com.br">dagobertosilveira@superig.com.br</a>; Raimunda Sampaio; Dorcas Lamounier Costa; Mark Nawacki; <a target="_blank" href="mailto:jurbina@mac.com">jurbina@mac.com</a>; Pierre BUFFET; <a target="_blank" href="mailto:joseanegodinho@yahoo.com.br">joseanegodinho@yahoo.com.br</a>; Robert Vinson; Shyam Sundarmail; <a target="_blank" href="mailto:robertobadaro768@gmail.com">robertobadaro768@gmail.com</a>; Leish-L; Fernando Koremblum; Chang, Kwang-Poo<br> <b><span style="font-weight: bold;">Subject:</span></b> RE: [Leish-l] miltefosine for diffuse leishmaniasis</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;">Dear Dr. Costas,</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;">Thermosurgery is committed to the research and treatment of leishmaniasis. We are pleased to work with you and assist your patients. We can lend you an instrument to use in your program. Our biggest hurdle is getting the equipment into the country. If you work with an NGO or government agency that can assist us in the importation that would be helpful. </span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;">Lets discuss the logistics to see if it is feasible to get you the equipment. I would suggest that you work with Dr David and Dr Satoskar on the recommended treatment protocol. </span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;">We would want to receive documentation regarding the use of the equipment and a paper so that we can educate others on the value of this treatment. </span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;">Warm regards,</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;">gena</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;margin-bottom: 12pt;"><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;">Gena Zischke<br> Business Development<br> Thermosurgery Technologies, Inc.<br> 2901 <st1:street w:st="on"><st1:address w:st="on">W. Indian School Rd.</st1:address></st1:street><br> <st1:place w:st="on"><st1:city w:st="on">Phoenix</st1:city>, <st1:state w:st="on">AZ</st1:state> <st1:postalcode w:st="on">85017</st1:postalcode></st1:place><br> Phone: (602) 264-7300<br> <br> <br> The information in this communication is confidential. It is intended solely for the addressee. Access to this communication by anyone else is unauthorized. If you are not the intended recipient, any disclosure, copying, distribution or any action taken or omitted to be taken in reliance on it, is prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return email, and destroy this communication and all copies thereof, including all attachments. Thank you. Thermosurgery Technologies, Inc.<br> <br> <br> Fax: (602) 248-3809</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <blockquote style="border-width: medium medium medium 1pt; border-style: none none none solid; border-color: -moz-use-text-color -moz-use-text-color -moz-use-text-color blue; padding: 0pt 0pt 0pt 4pt; margin-left: 3.95pt; margin-top: 5pt; margin-bottom: 5pt;"> <div> <div class="MsoNormal" style="font-size:12pt;margin-bottom: 12pt;"><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;">-------- Original Message --------<br> Subject: Re: [Leish-l] miltefosine for diffuse leishmaniasis<br> From: <st1:personname w:st="on">Carlos Costa</st1:personname> <<a target="_blank" href="mailto:chncosta@gmail.com">chncosta@gmail.com</a>><br> Date: Sun, July 10, 2011 4:23 pm<br> To: "Chang, Kwang-Poo" <<a href="http://KwangPoo.Chang@rosalindfranklin.edu" target="_blank">KwangPoo.Chang@rosalindfranklin.edu</a>><br> Cc: Josh Berman <<a target="_blank" href="mailto:Jbe9320457@aol.com">Jbe9320457@aol.com</a>>, <a target="_blank" href="mailto:dagobertosilveira@superig.com.br">dagobertosilveira@superig.com.br</a>,<br> Raimunda Sampaio <<a target="_blank" href="mailto:rsampaio@unb.br">rsampaio@unb.br</a>>, Dorcas Lamounier Costa<br> <<a href="http://dorcas.lc@gmail.com" target="_blank">dorcas.lc@gmail.com</a>>, Mark Nawacki <<a target="_blank" href="mailto:mnawacki@paladinlabs.com">mnawacki@paladinlabs.com</a>>,<br> <a target="_blank" href="mailto:jurbina@mac.com">jurbina@mac.com</a>, Pierre BUFFET <<a target="_blank" href="mailto:pierre.buffet@upmc.fr">pierre.buffet@upmc.fr</a>>,<br> <a target="_blank" href="mailto:joseanegodinho@yahoo.com.br">joseanegodinho@yahoo.com.br</a>, Robert Vinson <<a target="_blank" href="mailto:rvinson@paladinlabs.com">rvinson@paladinlabs.com</a>>,<br> Shyam Sundarmail <<a target="_blank" href="mailto:Drshyamsundar@hotmail.com">Drshyamsundar@hotmail.com</a>>,<br> <a target="_blank" href="mailto:robertobadaro768@gmail.com">robertobadaro768@gmail.com</a>, Leish-L <<a target="_blank" href="mailto:Leish-l@lineu.icb.usp.br">Leish-l@lineu.icb.usp.br</a>>, Fernando<br> Koremblum <<a target="_blank" href="mailto:fkorembl@paladinlabs.com">fkorembl@paladinlabs.com</a>><br> <br> KP, do you have any idea about prices? Please send me the brand name to see if I can easily import them. Best wishes to Jean, Carlos</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;">2011/7/10 Chang, Kwang-Poo <<a target="_blank" href="mailto:KwangPoo.Chang@rosalindfranklin.edu">KwangPoo.Chang@rosalindfranklin.edu</a>></span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;">Carlos will undoubtedly go with those, which are clinically acceptable and feasible for the sake of expediency. </span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;">In a separate message, the causative agent was said to have been identified as L amazonensis. Thermosensitivity of this species has been well-documented, suggestive of thermotherapy. There is already the suggestion of hot bath. One-use heat pad/heat wrap available over-the-counter in the <st1:country-region w:st="on"><st1:place w:st="on">USA</st1:place></st1:country-region> drug stores is just as innocuous to consider as some topical ointments suggested.</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="navy" face="Arial" size="2"><span style="font-size: 10pt; font-family: Arial; color: navy;">KP</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;text-align: center;" align="center"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <hr align="center" size="2" width="100%"> </span></font></div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black; font-weight: bold;">From:</span></font></b><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;"> <a target="_blank" href="mailto:leish-l-bounces@lineu.icb.usp.br">leish-l-bounces@lineu.icb.usp.br</a> [mailto:<a target="_blank" href="mailto:leish-l-bounces@lineu.icb.usp.br">leish-l-bounces@lineu.icb.usp.br</a>] <b><span style="font-weight: bold;">On Behalf Of </span></b><st1:personname w:st="on">Carlos Costa</st1:personname><br> <b><span style="font-weight: bold;">Sent:</span></b> Saturday, July 09, 2011 10:07 AM</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;"><br> <b><span style="font-weight: bold;">To:</span></b> Leish-L<br> <b><span style="font-weight: bold;">Cc:</span></b> Josh Berman; <a target="_blank" href="mailto:dagobertosilveira@superig.com.br">dagobertosilveira@superig.com.br</a>; Dorcas Lamounier Costa; <a target="_blank" href="mailto:jurbina@mac.com">jurbina@mac.com</a>; Pierre BUFFET; Robert Vinson; Raimunda Sampaio; Shyam Sundarmail; <a target="_blank" href="mailto:robertobadaro768@gmail.com">robertobadaro768@gmail.com</a>; Mark Nawacki; Fernando Koremblum; <a target="_blank" href="mailto:joseanegodinho@yahoo.com.br">joseanegodinho@yahoo.com.br</a></span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black; font-weight: bold;">Subject:</span></font></b><font color="black" face="Tahoma" size="2"><span style="font-size: 10pt; font-family: Tahoma; color: black;"> Re: [Leish-l] miltefosine for diffuse leishmaniasis</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="4"><span style="font-size: 13.5pt; font-family: Verdana; color: black;">Dear friends,</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="4"><span style="font-size: 13.5pt; font-family: Verdana; color: black;">This is really a such touching and motivated community, and leish-l is proving to be an excellent tool for solving the leishmaniasis toughest problems throughout the world. The word "together" sounds really powerful in such a cases.</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="4"><span style="font-size: 13.5pt; font-family: Verdana; color: black;">What os showing up from these kind emails is a face of science coming not only from the bench, the hospitals, the field, but a science coming straight from the heart.</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">Let me summarize some of the lessons and suggestions. Please correct me if I skip some.</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">1) Hot bath - <st1:city w:st="on"><st1:place w:st="on">Teresina</st1:place></st1:city> is very hot, and hot showers are rare here. However, we can easily provide her an electric shower. Should it be a tube? How long the bath would last?</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">2) BCG - one or two shots. We will do it. Any hint about the intervals between the shots?</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">3) Previous drug therapy: ImunoglucanTM (cell wall of <i><span style="font-style: italic;">Saccharomyces cerevisiae</span></i>), and saquinavir, after her delivery (</span></font><font color="black" face="Verdana"><span style="font-family: Verdana; color: black;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/18816190" target="_blank">Intracellular survival of Leishmania species that cause visceral leishmaniasis is significantly reduced by HIV-1 protease inhibitors.</a>).</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">4) Besides miltefosine we got a good hint where to find it (<st1:place w:st="on"><st1:city w:st="on">Paladino</st1:city>, <st1:country-region w:st="on">Canada</st1:country-region></st1:place>), which has excellent temporary effect (Zerpa et al, 2006), we should consider: </span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">a) lower/corrected doses of paramomycin (Bryceson) - we have also to find the drug outside <st1:country-region w:st="on"><st1:place w:st="on">Brazil</st1:place></st1:country-region>, since it is not distributed/approved here; </span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">b) gamma-interferon (who produces/sells it?).</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">c) fluconazol/itraconazol/(voriconazol?).</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">d) amiodarone - <i><span style="font-style: italic;">in vitro</span></i> testing does not sounds so good.</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">e) topic imiquimod (IxiumTM cream) - apparently easy to find. concentration of 5%?</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">f) photodynamic therapy - with Dr. Dagoberto Silveira, we are investigating where to do it around.</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">g) immunotherapy with suicide photo-inactivated <i><span style="font-style: italic;">Leishmania</span></i> (KP Chang).</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">Please check what really seems reasonable. My feeling is that most of the suggestions can be tried.</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">My warmest regards,</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="5"><span style="font-size: 18pt; font-family: Verdana; color: black;">Carlos.</span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </div> <div> <div style="margin-bottom: 12pt;"> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;">2011/7/8 Pierre BUFFET <<a target="_blank" href="mailto:pierre.buffet@upmc.fr">pierre.buffet@upmc.fr</a>><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;">Anthony,<br> <br> <br> because there are only a few options left, would you consider at one point low dose pentamidine (3 mg/kg every week or so, as you did in DCL patinets in <st1:country-region w:st="on"><st1:place w:st="on">Ethiopia</st1:place></st1:country-region> in the 70s if I remember)? Could be used either to stabilize the situation before starting on a coadministration, or as a maintenance after the co-administration, in both cases with careful monitoring of kidney function ?<br> <br> <st1:city w:st="on"><st1:place w:st="on">Pierre</st1:place></st1:city><br> <br> <br> Anthony Bryceson <<a target="_blank" href="mailto:a.bryceson@doctors.org.uk">a.bryceson@doctors.org.uk</a>> a écrit :<o:p></o:p></span></font></div> </div> <div> <div> <blockquote style="border-width: medium medium medium 1pt; border-style: none none none solid; border-color: -moz-use-text-color -moz-use-text-color -moz-use-text-color windowtext; padding: 0pt 0pt 0pt 6pt; margin: 5pt 0pt 5pt 4.8pt;"> <div style="margin-bottom: 12pt;"> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> <div style="margin-bottom: 12pt;"> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;">Dear Carlos<br> As you are well aware DCL is very difficult to treat. The big problem is that the defect in specific CMI is more profound than that in VL and may never recover, in contrast with the defect in VL which bounces back quickly.<br> <br> To have any chance of curing the patient, treatment should be monitored by quantitative slit skin smears (as for splenic aspirates in VL) from multiple pre-selected sites, every week or two weeks, and treatment continued until negativity and for some weeks or months longer. When slit skin smears become negative, hunt for any nodular or infiltrated lesions and take deep biopsies and look for amastigotes there. Keep on hunting and smearing. Sometimes, at the end of all this, evidence of CMI may appear, and cure becomes a possibility. I am sure that the method of treating is more important than the choice of drug - so long of course that the parasite is susceptible to the drug.<br> <br> Hannah Akuffo has sent you the abstract relating to 3 patients treated by Sabawork Teklemariam in Addis Abeba. That article details this approach.<br> <br> Do you know the species of Leishmania causing Maria's DCL, and its sensitivities? In Addis Abeba parasites were cultured from two of the patients and sensitivities determined and isobolograms drawn to look for synergy. The isolates were sensitive to paromomycin and sodium stibogluconate was synergistic. It would be worth while to make cultures before you start any new treatment and have the isolate tested in this way. I expect that you have a lab that could do this; if not, Simon Croft might be able to advise.<br> <br> Miltefosine has been very successful in a number of situations in South American CL and showed promise for DCL, but patients relapsed despite prolonged treatment.<br> 1. Zerpa O, Ulrich M, Blanco B, et al. Diffuse cutaneous leishmaniasis responds to miltefosine but then relapses. Br J Dermatol. 2007;156:1328-1335.<br> <br> In a few patients with VL-HIV confection whom I treated in <st1:city w:st="on"><st1:place w:st="on">London</st1:place></st1:city>, miltefosine worked well at first, but the patients relpased while still on treatment and drug resistance was supected but not tested. Miltefosine has a pharmacokinetic profile with a long tail that might make it susceptible to the devlopment of resistance, especially if the therapeutic window for a given isolate was narrow. So you might want to think about adding a second drug to go with miltefosine from the beginning. I am not sure what might be the best drug for combination; perhaps Josh Berman might have an opinion. It is of course essential to ensure contraception.<br> <br> You could also consider the combination of paromomycin and low dose SSG. In view of Maria's poor renal function you might need to modify the dose of paromomycin and to monitor function.<br> <br> Robert Vinson is CEO of Paladin Labs, and would I am sure help you locate miltefosine. <<a target="_blank" href="mailto:rvinson@paladin-labs.com">rvinson@paladin-labs.com</a>><br> <br> Richard Chin is CEO of One World Health, and would, I am equally sure, help you locate paromomycin, should you consider that path. <a href="http://www.oneworldhealth.org/contact-us" target="_blank">http://www.oneworldhealth.org/contact-us</a> Phone: +1 415-421-4700 Fax: +1 415-421-4747<br> <br> I wish you and Maria all the best in this venture.<br> Anthony<br> <br> <br> Dear Jennie<br> Immunotherapy proved rather disappointing in VL. It seems that the patient needs a decent immune response in the first place to benefit from immuno-boosting.<br> Sadly<br> Anthony<br> <br> <br> On 6 Jul 2011, at 20:04, <st1:personname w:st="on">Carlos Costa</st1:personname> wrote:<o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;">Dear all,<br> <br> Maria Cleudimar has cutaneous diffuse leishmaniasis due to Leishmania amazonensis. She used to be a long time patient form Dr. Jackson Costa, in the countryside of <st1:place w:st="on"><st1:city w:st="on">Maranhão State</st1:city>, <st1:country-region w:st="on">Brazil</st1:country-region></st1:place>, since she was 10 years old, after a disease that started when she was just five. Now, she is under my and Dorcas care, at the age of 30, living in the city of <st1:city w:st="on"><st1:place w:st="on">Teresina</st1:place></st1:city>.<br> <br> Her long time DCL does not respond to the treatment antimonium anymore. Although we still prescribe liposomal amphotericin B at very low dose (3mg/kg/once a week), her situation is deteriorating progressively, her renal function does not allow any additional dosing since creatinine is presently above 3mg/dL, and previous biopsy had shown tubular damage apparently secondary to the drug, without evidence of amyloidosis. We tried several combinations of different drugs, without success. Her situation worsened a lot during her recent pregnancy (the baby is eight months old now).<br> <br> Our hope now stands only in miltefosine, for oral chronic use, but the drug is not licensed or available in <st1:country-region w:st="on"><st1:place w:st="on">Brazil</st1:place></st1:country-region> yet (to my knowledge).<br> <br> With her permission I attached some of her pictures, hoping to sensitize critical people in order to help me to get miltefosine and the permission for prescription in <st1:country-region w:st="on"><st1:place w:st="on">Brazil</st1:place></st1:country-region> (or any other oral drug with promising efficacy, and without nephrotoxicity, if known). Moreover, we need to know about the dose adjustment for the renal impairment, and how long the drug could safely be used.<br> <br> One picture shows her face before treatment, and another after the pregnancy, with the baby. One shows the situation of her thighs, another the calf of the leg and the last one the infiltration of the palate.<br> <br> Hoping a little from friends, my kindest regards,<br> <br> Carlos.<br> <br> PS. Please understand that the pictures are allowed not for publication or public presentation. Cleudimar permission is restricted to this forum.<br> <br> <br> --<br> Carlos H. N. Costa, MD, DSc.<br> President<br> Sociedade Brasileira de Medicina Tropical<br> (Brazilian Society of Tropical Medicine)<br> Instituto de Doenças Tropicais Natan Portella<br> Universidade Federal do Piauí<br> Rua Artur de Vasconcelos 151-Sul<br> 64049-750 Teresina-PI<br> <st1:country-region w:st="on"><st1:place w:st="on">Brazil</st1:place></st1:country-region><br> Telephones: +55 86 3221-3413 (work); +55 86 8838-3303 (mobile).<br> <br> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas pelo sigilo legal, por direitos autorais e destinadas exclusivamente à pessoa ou organização para a qual a mensagem foi destinada.<br> Warning: This message is meant only for the intended recipient of the transmission. It is forbidden any unauthorized use, alteration, reproduction and distribution. If you are not the correct recipient, please notify us immediately by return e-mail and delete this message from your system.<br> <br> <cleu antes grav 13jan09.jpg><cleu e nene.jpg><cleu santada recorte.jpg><cleu panturrilhas.jpg><cleu palato.jpg>_______________________________________________<br> Leish-l mailing list<br> <a target="_blank" href="mailto:Leish-l@lineu.icb.usp.br">Leish-l@lineu.icb.usp.br</a><br> <a href="http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l" target="_blank">http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l</a><o:p></o:p></span></font></div> </div> <div style="margin-bottom: 12pt;"> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </blockquote> <div style="margin-bottom: 12pt;"> <div class="MsoNormal" style="font-size:12pt;margin-bottom: 12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </div> </div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"><br> <br clear="all"> <br> -- <br> </span></font><b><font color="black" face="Verdana"><span style="font-family: Verdana; color: black; font-weight: bold;">Carlos H. N. Costa, MD, DSc.</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="3"><span style="font-size: 12pt; font-family: Verdana; color: black; font-weight: bold;">President</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="3"><span style="font-size: 12pt; font-family: Verdana; color: black; font-weight: bold;">Sociedade Brasileira de Medicina Tropical </span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="3"><span style="font-size: 12pt; font-family: Verdana; color: black; font-weight: bold;">(Brazilian Society of Tropical Medicine)</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="3"><span style="font-size: 12pt; font-family: Verdana; color: black; font-weight: bold;">Instituto de Doenças Tropicais Natan Portella<br> Universidade Federal do Piauí</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="3"><span style="font-size: 12pt; font-family: Verdana; color: black; font-weight: bold;">Rua Artur de Vasconcelos 151-Sul</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="3"><span style="font-size: 12pt; font-family: Verdana; color: black; font-weight: bold;">64049-750 Teresina-PI<br> <st1:country-region w:st="on"><st1:place w:st="on">Brazil</st1:place></st1:country-region><br> Telephones: +55 86 3221-3413 (work); +55 86 8838-3303 (mobile).<br> </span></font></b><font color="black" face="Verdana"><span style="font-family: Verdana; color: black;"><br> </span></font><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;">Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas pelo sigilo legal, por direitos autorais e destinadas exclusivamente à pessoa ou organização para a qual a mensagem foi destinada.<br> Warning: This message is meant only for the intended recipient of the transmission. It is forbidden any unauthorized use, alteration, reproduction and distribution. If you are not the correct recipient, please notify us immediately by return e-mail and delete this message from your system. </span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> </div> </div> </div> </div> </div> </div> </div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;"><br> <br clear="all"> <br> -- <br> <b><span style="font-weight: bold;">Carlos H. N. Costa, MD, DSc.</span></b></span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black; font-weight: bold;">President</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black; font-weight: bold;">Sociedade Brasileira de Medicina Tropical </span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black; font-weight: bold;">(Brazilian Society of Tropical Medicine)</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black; font-weight: bold;">Instituto de Doenças Tropicais Natan Portella<br> Universidade Federal do Piauí</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black; font-weight: bold;">Rua Artur de Vasconcelos 151-Sul</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black; font-weight: bold;">64049-750 Teresina-PI<br> <st1:country-region w:st="on"><st1:place w:st="on">Brazil</st1:place></st1:country-region><br> Telephones: +55 86 3221-3413 (work); +55 86 8838-3303 (mobile).<br> </span></font></b><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;"><br> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas pelo sigilo legal, por direitos autorais e destinadas exclusivamente à pessoa ou organização para a qual a mensagem foi destinada.<br> Warning: This message is meant only for the intended recipient of the transmission. It is forbidden any unauthorized use, alteration, reproduction and distribution. If you are not the correct recipient, please notify us immediately by return e-mail and delete this message from your system. </span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"> <o:p></o:p></span></font></div> <div class="MsoNormal" style="font-size:12pt;text-align: center;" align="center"><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;"> <hr align="center" size="2" width="100%"> </span></font></div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;">_______________________________________________<br> Leish-l mailing list<br> <a target="_blank" href="mailto:Leish-l@lineu.icb.usp.br">Leish-l@lineu.icb.usp.br</a><br> <a href="http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l" target="_blank">http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l</a></span></font><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> </blockquote> </div> </div> </div> </div> </div> <div class="MsoNormal" style="font-size:12pt;"><font color="black" face="Times New Roman" size="3"><span style="font-size: 12pt; color: black;"><br> <br clear="all"> <br> -- <br> </span></font><b><font color="black" face="Verdana"><span style="font-family: Verdana; color: black; font-weight: bold;">Carlos H. N. Costa, MD, DSc.</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="3"><span style="font-size: 12pt; font-family: Verdana; color: black; font-weight: bold;">President</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="3"><span style="font-size: 12pt; font-family: Verdana; color: black; font-weight: bold;">Sociedade Brasileira de Medicina Tropical </span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="3"><span style="font-size: 12pt; font-family: Verdana; color: black; font-weight: bold;">(Brazilian Society of Tropical Medicine)</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="3"><span style="font-size: 12pt; font-family: Verdana; color: black; font-weight: bold;">Instituto de Doenças Tropicais Natan Portella<br> Universidade Federal do Piauí</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="3"><span style="font-size: 12pt; font-family: Verdana; color: black; font-weight: bold;">Rua Artur de Vasconcelos 151-Sul</span></font></b><font color="black"><span style="color: black;"><o:p></o:p></span></font></div> </div> <div> <div class="MsoNormal" style="font-size:12pt;"><b><font color="black" face="Verdana" size="3"><span style="font-size: 12pt; font-family: Verdana; color: black; font-weight: bold;">64049-750 Teresina-PI<br> <st1:country-region w:st="on"><st1:place w:st="on">Brazil</st1:place></st1:country-region><br> Telephones: +55 86 3221-3413 (work); +55 86 8838-3303 (mobile).<br> </span></font></b><font color="black" face="Verdana"><span style="font-family: Verdana; color: black;"><br> </span></font><font color="black" face="Verdana" size="2"><span style="font-size: 10pt; font-family: Verdana; color: black;">Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas pelo sigilo legal, por direitos autorais e destinadas exclusivamente à pessoa ou organização para a qual a mensagem foi destinada.<br> Warning: This message is meant only for the intended recipient of the transmission. 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