<html><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><div><p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;mso-pagination:
none;mso-layout-grid-align:none;text-autospace:none"><span style="font-size:
13.0pt;font-family:Helvetica;mso-bidi-font-family:Verdana">Dear KP</span></p><p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;mso-pagination:
none;mso-layout-grid-align:none;text-autospace:none"><span style="font-size:
13.0pt;font-family:Helvetica;mso-bidi-font-family:Verdana">There is a
fundamental point that needs to be noted <span style="mso-spacerun:
yes"> </span>Applying heat to the area and using Thermomed treatment to
stimulate radiowave is not the same. We do not apply heat but generate
heat at the molecular level. I don’t think that the same effects are
occurring at the cellular level when heat is being applied versus agitating the
molecules to where they generate heat. I understand that what occurs at the cellular level using radio waves is being studied currently at the VA Hospital in Arizona. </span></p><p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;mso-pagination:
none;mso-layout-grid-align:none;text-autospace:none"><span style="font-size:
13.0pt;font-family:Helvetica;mso-bidi-font-family:Verdana">John</span></p><p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;mso-pagination:
none;mso-layout-grid-align:none;text-autospace:none"><span style="font-size:
13.0pt;font-family:Helvetica;mso-bidi-font-family:Verdana"><br></span></p>
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<div><div>On Jun 16, 2011, at 2:35 AM, buffet pierre wrote:</div><br class="Apple-interchange-newline"><blockquote type="cite"><div>There was also a very nice poster at the last ASTMH Meeting from a colleague from Tulasne in collaboration with Alejandro LLanos-Cuentas using inexpensive plastic bags of sodium acetate that reach temperatures close to 50°C. For an enhancing effect a few seconds of contact would probably be enough.<br><br>Pierre<br><br>Pierre Buffet MCU-PH<br>Service de Parasitologie Mycologie Pr. Mazier<br>Hôpital Pitié Salpêtrière<br>+ 33 (0)1 42 16 01 31 + 33 (0)6 23 21 43 00<br><br>Adresse postale Mailing address:<br>Groupe Hospitalier Pitié-salpêtrière<br>47 Boulevard de l'hôpital <br>75651 Paris Cedex 13<br>France<br>Visite our webside: <a href="http://www.umrs945.upmc.fr/fr/equipe_dominique_mazier.html">http://www.umrs945.upmc.fr/fr/equipe_dominique_mazier.html</a><br><br>----- Message d'origine -----<br>De: "Chang, Kwang-Poo" <<a href="mailto:KwangPoo.Chang@rosalindfranklin.edu">KwangPoo.Chang@rosalindfranklin.edu</a>><br>Date: Jeudi, Juin 16, 2011 12:48 am<br>Objet: Re: [Leish-l] inquiry<br>À: John David <<a href="mailto:jdavid@hsph.harvard.edu">jdavid@hsph.harvard.edu</a>>, "Magill, Alan J COL MIL USA MEDCOM<span class="Apple-tab-span" style="white-space:pre"> </span>WRAIR" <<a href="mailto:ALAN.MAGILL@US.ARMY.MIL">ALAN.MAGILL@US.ARMY.MIL</a>><br>Cc: "Satoskar, Abhay" <<a href="mailto:Abhay.Satoskar@osumc.edu">Abhay.Satoskar@osumc.edu</a>>, <a href="mailto:vishwamohan_katoch@yahoo.co.in">vishwamohan_katoch@yahoo.co.in</a>, Raj <<a href="mailto:raj@cellabs.com.au">raj@cellabs.com.au</a>>, <a href="mailto:leish-l@lineu.icb.usp.br">leish-l@lineu.icb.usp.br</a><br><br><br><blockquote type="cite">I put my index finger into a 50 C water bath and can only stand the heat<br></blockquote><blockquote type="cite"> for ~15 seconds. <br></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"> I wonder if someone might have tried air-activated heat pads/wraps,<br></blockquote><blockquote type="cite"> which are inexpensive and readily available in Walgreen/CVS drug stores<br></blockquote><blockquote type="cite"> for treating muscle pains. The temperature probably doesn't go much<br></blockquote><blockquote type="cite"> above 40 C, but it lasts for hours and can be repeatedly applied. I used<br></blockquote><blockquote type="cite"> such items without experiencing any problem.<br></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"> KP<br></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"> -----Original Message-----<br></blockquote><blockquote type="cite"> From: John David [<a href="mailto:jdavid@hsph.harvard.edu">mailto:jdavid@hsph.harvard.edu</a>] <br></blockquote><blockquote type="cite"> Sent: Wednesday, June 08, 2011 5:34 PM<br></blockquote><blockquote type="cite"> To: Magill, Alan J COL MIL USA MEDCOM WRAIR<br></blockquote><blockquote type="cite"> Cc: Chang, Kwang-Poo; Satoskar, Abhay; <a href="mailto:vishwamohan_katoch@yahoo.co.in">vishwamohan_katoch@yahoo.co.in</a>;<br></blockquote><blockquote type="cite"> Raj; <a href="mailto:leish-l@lineu.icb.usp.br">leish-l@lineu.icb.usp.br</a><br></blockquote><blockquote type="cite"> Subject: Re: [Leish-l] inquiry<br></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"> Local anesthesia must be given when using heat therapy. I should <br></blockquote><blockquote type="cite"> mention that some have advocated local lesion injection of <br></blockquote><blockquote type="cite">pentavalent <br></blockquote><blockquote type="cite"> antimony. This, usually given without anesthesia, is very painful. I <br></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"> have seen it given in a clinic where adults winced terribly and it <br></blockquote><blockquote type="cite">was <br></blockquote><blockquote type="cite"> complete bedlam with the loud piercing screams of children.<br></blockquote><blockquote type="cite"> And they had to return weekly for at least five times. I can't <br></blockquote><blockquote type="cite"> recommend that.<br></blockquote><blockquote type="cite"> John David<br></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"> On Jun 8, 2011, at 3:45 PM, Magill, Alan J COL MIL USA MEDCOM WRAIR <br></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"> wrote:<br></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><blockquote type="cite">John certainly knows well..<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite"><br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">50C is not tolerable to human skin. All potential lesions to be <br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">treated need to be appropriately cleaned and anesthetized with <br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">intradermal and subQ injection of lidocaine. I have never tried the <br></blockquote></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><blockquote type="cite">newer lidocaine creams such as EMLA, they might work as well. This <br></blockquote></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><blockquote type="cite">can be somewhat rate limiting for multiple lesions as each lesion <br></blockquote></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><blockquote type="cite">needs to be prepared, injected, and you need to wait about 10 plus <br></blockquote></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><blockquote type="cite">minutes for the lidocaine to work.<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite"><br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">Trying the Thermomed device on normal skin (try on yourself) will <br></blockquote></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><blockquote type="cite">show that most people can only get to about 43 or 44 C before <br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">quickly removing the device from their skin.<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite"><br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">Alan Magill<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite"><br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite"><br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">________________________________<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">From: <a href="mailto:leish-l-bounces@lineu.icb.usp.br">leish-l-bounces@lineu.icb.usp.br</a><br></blockquote></blockquote><blockquote type="cite"> [<a href="mailto:leish-l-bounces@lineu.icb.usp.br">leish-l-bounces@lineu.icb.usp.br</a> <br></blockquote><blockquote type="cite"><blockquote type="cite">] On Behalf Of Chang, Kwang-Poo [<a href="mailto:KwangPoo.Chang@rosalindfranklin.edu">KwangPoo.Chang@rosalindfranklin.edu</a>]<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">Sent: Monday, June 06, 2011 12:02 PM<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">To: John David<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">Cc: Satoskar, Abhay; <a href="mailto:vishwamohan_katoch@yahoo.co.in">vishwamohan_katoch@yahoo.co.in</a>; Raj;<br></blockquote></blockquote><blockquote type="cite"> <a href="mailto:leish-l@lineu.icb.usp.br">leish-l@lineu.icb.usp.br</a><br></blockquote><blockquote type="cite"><blockquote type="cite">Subject: Re: [Leish-l] inquiry<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite"><br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">Any chance to make it available for additional trials elsewhere ?<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite"><br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">I recall your statement in our conversation about the advantage of <br></blockquote></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><blockquote type="cite">this instrument over the heating lamp. That is to maintain the <br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">specific elevated temperature uniformly throughout the skin lesion <br></blockquote></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><blockquote type="cite">for a sustained period. The 50 C must be the effective temperature <br></blockquote></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><blockquote type="cite">that has been experimentally determined. It seems to be a tolerable <br></blockquote></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><blockquote type="cite">temperature to human skin ? Dr. Sharma may comment on this <br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">medically as a dermatologist ?<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite"><br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">KP<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite"><br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">________________________________<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">From: John David [<a href="mailto:jdavid@hsph.harvard.edu">mailto:jdavid@hsph.harvard.edu</a>]<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">Sent: Sunday, June 05, 2011 11:18 PM<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">To: Chang, Kwang-Poo<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">Cc: Sharmanl; Satoskar, Abhay; Raj; Petr Volf;<br></blockquote></blockquote><blockquote type="cite"> <a href="mailto:leish-l@lineu.icb.usp.br">leish-l@lineu.icb.usp.br</a> <br></blockquote><blockquote type="cite"><blockquote type="cite">; <a href="mailto:hgoto@usp.br">hgoto@usp.br</a>; <a href="mailto:elfadil_abass@yahoo.com">elfadil_abass@yahoo.com</a>;<br></blockquote></blockquote><blockquote type="cite"> <a href="mailto:vishwamohan_katoch@yahoo.co.in">vishwamohan_katoch@yahoo.co.in</a><br></blockquote><blockquote type="cite"><blockquote type="cite">Subject: Re: [Leish-l] inquiry<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite"><br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">The Themomed instrument shown below can produce accurate 50 degrees <br></blockquote></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><blockquote type="cite">C plus or minus 0.2 degrees temperature by radio wave.<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">from Themorsurgery Technologies. Picture below.<br></blockquote></blockquote><blockquote type="cite"><blockquote type="cite">Two papers of a trial in Brazil and one in Afghanistan on CL below.<br></blockquote></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"><br></blockquote><blockquote type="cite"> _______________________________________________<br></blockquote><blockquote type="cite"> Leish-l mailing list<br></blockquote><blockquote type="cite"> <a href="mailto:Leish-l@lineu.icb.usp.br">Leish-l@lineu.icb.usp.br</a><br></blockquote><blockquote type="cite"> <a href="http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l">http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l</a><br></blockquote><blockquote type="cite"><br></blockquote></div></blockquote></div><br></div></body></html>