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<DIV><FONT size=2 face=Arial>Hi KP,</FONT></DIV>
<DIV><FONT size=2 face=Arial>Certainly I will do. Please suggest Dr NL Sharma to
do so.</FONT></DIV>
<DIV><FONT size=2 face=Arial>Raj</FONT></DIV>
<BLOCKQUOTE
style="BORDER-LEFT: #000000 2px solid; PADDING-LEFT: 5px; PADDING-RIGHT: 0px; MARGIN-LEFT: 5px; MARGIN-RIGHT: 0px">
<DIV style="FONT: 10pt arial">----- Original Message ----- </DIV>
<DIV
style="FONT: 10pt arial; BACKGROUND: #e4e4e4; font-color: black"><B>From:</B>
<A title=KwangPoo.Chang@rosalindfranklin.edu
href="mailto:KwangPoo.Chang@rosalindfranklin.edu">Chang, Kwang-Poo</A> </DIV>
<DIV style="FONT: 10pt arial"><B>To:</B> <A title=raj@cellabs.com.au
href="mailto:raj@cellabs.com.au">Raj</A> ; <A
title=hanafi.hanafi.ctr.eg@med.navy.mil
href="mailto:hanafi.hanafi.ctr.eg@med.navy.mil">Hanafi, Hanafi CTR EG NAMRU3
</A>; <A title=nandlals@hotmail.com
href="mailto:nandlals@hotmail.com">nandlals@hotmail.com</A> ; <A
title=leish-l@lineu.icb.usp.br
href="mailto:leish-l@lineu.icb.usp.br">leish-l@lineu.icb.usp.br</A> </DIV>
<DIV style="FONT: 10pt arial"><B>Sent:</B> Thursday, June 02, 2011 8:41
AM</DIV>
<DIV style="FONT: 10pt arial"><B>Subject:</B> RE: cutaneous form of leish in
Indian region</DIV>
<DIV><BR></DIV>
<DIV class=Section1>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt">Great if Dr. Sharma
would be able to send serum samples to you for evaluating your
species-specific exo-antigens.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt">KP<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT color=navy size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; COLOR: navy; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<DIV>
<DIV style="TEXT-ALIGN: center" class=MsoNormal align=center><FONT size=3
face="Times New Roman"><SPAN style="FONT-SIZE: 12pt">
<HR tabIndex=-1 align=center SIZE=2 width="100%">
</SPAN></FONT></DIV>
<P class=MsoNormal><B><FONT size=2 face=Tahoma><SPAN
style="FONT-FAMILY: Tahoma; FONT-SIZE: 10pt; FONT-WEIGHT: bold">From:</SPAN></FONT></B><FONT
size=2 face=Tahoma><SPAN style="FONT-FAMILY: Tahoma; FONT-SIZE: 10pt"> Raj
[mailto:raj@cellabs.com.au] <BR><B><SPAN
style="FONT-WEIGHT: bold">Sent:</SPAN></B> Tuesday, May 31, 2011 9:18
PM<BR><B><SPAN style="FONT-WEIGHT: bold">To:</SPAN></B> Hanafi, Hanafi CTR EG
NAMRU3 ; Chang, Kwang-Poo; <A
href="mailto:nandlals@hotmail.com">nandlals@hotmail.com</A>; <A
href="mailto:leish-l@lineu.icb.usp.br">leish-l@lineu.icb.usp.br</A><BR><B><SPAN
style="FONT-WEIGHT: bold">Subject:</SPAN></B> cutaneous form of leish in
Indian region</SPAN></FONT><o:p></o:p></P></DIV>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><o:p> </o:p></SPAN></FONT></P>
<DIV>
<DIV>
<P class=MsoNormal><st1:Street w:st="on"><st1:address w:st="on"><FONT size=2
face=Arial><SPAN style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">G'Day
Dr</SPAN></FONT></st1:address></st1:Street><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">
Hanafi,<o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">My enquiry was to know whether
<EM><I><FONT face=Arial><SPAN style="FONT-FAMILY: Arial">L.
donovani</SPAN></FONT></I></EM> in <st1:country-region w:st="on"><st1:place
w:st="on">India</st1:place></st1:country-region> produces a cutaneous
form of lesion or not (I am not referring to PKDL form). There
are many reports from SriLanka about the cutaneous manifestations
by <EM><I><FONT face=Arial><SPAN style="FONT-FAMILY: Arial">L.
donovani</SPAN></FONT></I></EM>. The PKDL although is a
cutaneous response appears very late in the infection process
and this is ascribed to be a protective response against the
parasite. <o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"> <o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Prof Chang mentioned
<o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">"Analyses of several batches of
basically clinical CL samples from Dr. Sharma showed evidence of L infantum,
but also L tropica as well as a mixture of the two in one sample. This is the
same picture we have noted for samples from <st1:place w:st="on"><st1:City
w:st="on">Hatay</st1:City>, <st1:country-region
w:st="on">Turkey</st1:country-region></st1:place>." This is from <st1:place
w:st="on">Sutlej</st1:place> region." It means this cutaneous complex
requires some investigation. <o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"> <o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">I raise species-specific
exo-antigens from <EM><I><FONT face=Arial><SPAN style="FONT-FAMILY: Arial">L.
tropica</SPAN></FONT></I></EM> and <EM><I><FONT face=Arial><SPAN
style="FONT-FAMILY: Arial">L infantum</SPAN></FONT></I></EM> and I am prepared
to test the serum /plasma samples for presence of antibodies. If Dr NL
Sharma is prepared to send me specimens as well as clinical plasma or serum
samples I would be interested to investigate the antibody response in these
situations. <o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"> <o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Dr
Raj<o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Cellabs<o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">----- Original Message -----
<o:p></o:p></SPAN></FONT></P>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">From: "Hanafi, Hanafi CTR EG
NAMRU3 " <<A
href="mailto:hanafi.hanafi.ctr.eg@med.navy.mil">hanafi.hanafi.ctr.eg@med.navy.mil</A>><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">To: "Raj" <<A
href="mailto:raj@cellabs.com.au">raj@cellabs.com.au</A>>; <<A
href="mailto:leish-l@lineu.icb.usp.br">leish-l@lineu.icb.usp.br</A>><o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Sent: Tuesday, May 31, 2011 6:19
PM<o:p></o:p></SPAN></FONT></P></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Subject: RE: [Leish-l] Leish-l
Digest, Vol 41, Issue 9<o:p></o:p></SPAN></FONT></P></DIV></DIV>
<DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P></DIV>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">> Dear Dr Raj:<BR>> <BR>>
I think you mean PKDL (post kala azar dermal leishmanisis) caused by
L.<BR>> donovani and it usually seen as a late complication of the disease.
PKDL has<BR>> been reported in <st1:country-region
w:st="on">India</st1:country-region>, <st1:country-region
w:st="on">Kenya</st1:country-region> and <st1:country-region
w:st="on"><st1:place w:st="on">Sudan</st1:place></st1:country-region>.<BR>>
<BR>> Thank you <BR>> R/<BR>> Hanafi<BR>> <BR>>
Hanafi A. Hanafi, Ph. D.<BR>> Medical Research
Scientist<BR>> Vector Biology Research Program<BR>> <st1:country-region
w:st="on"><st1:place w:st="on">U.S.</st1:place></st1:country-region> Naval
Medical Research Unit No.3<BR>> <st1:place w:st="on"><st1:City
w:st="on">Cairo</st1:City>, <st1:country-region
w:st="on">Egypt</st1:country-region></st1:place><BR>> Tel & Fax:
++2-02-2342-3090<BR>> E-mail: <A
href="mailto:hanafi.hanafi.ctr.eg@med.navy.mil">hanafi.hanafi.ctr.eg@med.navy.mil</A><BR>>
<A href="mailto:yahanafi@yahoo.com">yahanafi@yahoo.com</A><BR>>
</SPAN></FONT><o:p></o:p></P></DIV>
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