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<DIV>Jacques,</DIV>
<DIV> You are right. If allopurinol is as good as Glucantime,
it should be used universally. Can you give us references to trials that show
this? if not, who will do a double blind trial and settle the question once and
for all. Are there any other than Jacques who have an opinion for us?</DIV>
<DIV>Bob</DIV>
<DIV> </DIV>
<DIV>Carlos,</DIV>
<DIV> It may be forbidden in Brazil. But Glucantime is widely
used in Europe in spite of the old Italian study showing the danger of selecting
resistance. (By 'old Italian', I mean a study done some time ago - it is not a
reference to the age of the workers who did the study. I would not want to
offend my friend Luigi Gradoni!)</DIV>
<DIV>Bob</DIV>
<BLOCKQUOTE
style="PADDING-RIGHT: 0px; PADDING-LEFT: 5px; MARGIN-LEFT: 5px; BORDER-LEFT: #000000 2px solid; MARGIN-RIGHT: 0px">
<DIV style="FONT: 10pt arial">----- Original Message ----- </DIV>
<DIV
style="BACKGROUND: #e4e4e4; FONT: 10pt arial; font-color: black"><B>From:</B>
<A title=cbrisola@mbox1.ufsc.br href="mailto:cbrisola@mbox1.ufsc.br">Carlos
Brisola Marcondes</A> </DIV>
<DIV style="FONT: 10pt arial"><B>To:</B> <A title=Jaclamothe@aol.com
href="mailto:Jaclamothe@aol.com">Jaclamothe@aol.com</A> </DIV>
<DIV style="FONT: 10pt arial"><B>Cc:</B> <A title=leish-l@lineu.icb.usp.br
href="mailto:leish-l@lineu.icb.usp.br">leish-l@lineu.icb.usp.br</A> </DIV>
<DIV style="FONT: 10pt arial"><B>Sent:</B> Tuesday, April 07, 2009 3:16
PM</DIV>
<DIV style="FONT: 10pt arial"><B>Subject:</B> Re: [Leish-l] Back to
business</DIV>
<DIV><BR></DIV>
<DIV>Dear all</DIV>
<DIV> I would remind that the utilization for dogs of drugs
utilized for humans was forbidden in the last year by federal
government.</DIV>
<DIV> Would it be viable to treat thousands of dogs in the huge
(and variable) endemic area of Brazil, which are replaced very quickly?
Would any of us like to have positive dogs being treated in our
neighbourhood?</DIV>
<DIV> </DIV>
<DIV>Best wishes</DIV>
<DIV>Carlos Brisola Marcondes----- Original Message ----- </DIV>
<BLOCKQUOTE
style="PADDING-RIGHT: 0px; PADDING-LEFT: 5px; MARGIN-LEFT: 5px; BORDER-LEFT: #000000 2px solid; MARGIN-RIGHT: 0px">
<DIV
style="BACKGROUND: #e4e4e4; FONT: 10pt arial; font-color: black"><B>From:</B>
<A title=Jaclamothe@aol.com
href="mailto:Jaclamothe@aol.com">Jaclamothe@aol.com</A> </DIV>
<DIV style="FONT: 10pt arial"><B>To:</B> <A title=killickendrick@wanadoo.fr
href="mailto:killickendrick@wanadoo.fr">killickendrick@wanadoo.fr</A> ; <A
title=leish-l@lineu.icb.usp.br
href="mailto:leish-l@lineu.icb.usp.br">leish-l@lineu.icb.usp.br</A> </DIV>
<DIV style="FONT: 10pt arial"><B>Sent:</B> Monday, April 06, 2009 7:55
PM</DIV>
<DIV style="FONT: 10pt arial"><B>Subject:</B> Re: [Leish-l] Back to
business</DIV>
<DIV><BR></DIV><FONT id=role_document face=Arial color=#000000 size=2>
<DIV>
<DIV>
<DIV>Dans un e-mail daté du 04/04/2009 19:55:11 Paris, Madrid (heure d'été),
<A href="mailto:killickendrick@wanadoo.fr">killickendrick@wanadoo.fr</A> a
écrit :</DIV>
<BLOCKQUOTE
style="PADDING-LEFT: 5px; MARGIN-LEFT: 5px; BORDER-LEFT: blue 2px solid"><FONT
style="BACKGROUND-COLOR: transparent" face=Arial color=#000000 size=2>
<DIV>Surely Jacques is not recommending allopuriol alone as treatment? I
seem to remember a study that showed this was not a good idea.</DIV>
<DIV>In France, Glucantime is geverally the answer to CanL with
allopurinol as well. Dogs are not destroyed by law. Medical doctors
question the use of Glucantime because of the risk of drug
resustance.</DIV>
<DIV> By the way, 'vaccinated' dogs in Brazil are
presumably seropositive. if so, they should be killed!</DIV>
<DIV> Bob Killick-Kendrick</DIV></FONT></BLOCKQUOTE></DIV>
<DIV></DIV> Allopurinol
alone has a great advantage , the risk of creating resistance transmitted to
humans is neglectable (compared with antimonials or ampho b ) </DIV>
<DIV>Pr Slappedel in Netherland has begun and had good results
(80% long term efficacy) . The paper you mention was published in
99 . It was a comparative study , but in the group allopurinol
alone, dogs were only treated 1 month... (its difficult to make
a clinical studies with dogs belonging to owners) It is for me
impossible to make any conclusion from these results even if it
has been done...</DIV>
<DIV> </DIV>
<DIV>In Greece , Pr Koutinas in a 4 months study has 100% improvement
and 50% of clinical cure . They have also excellent results in the most
severe forms of cl (renal disease) . Gad Baneth uses also this treatment in
Israel </DIV>
<DIV>In the american focus , ive treated and closely followed around 20
dogs (Glucantime was not available , and i didnt want to use
it) and it was a succes. The only problem is that clinical cure is
reached after a longer time than with the classic association Glucantime
allopurinol. But dogs dont go to work on mondays. </DIV>
<DIV> </DIV>
<DIV>There is an emerging consensus in the vet community to avoid the use of
Glucantime and amphotericin B (recent papers of the vet leish group in
Trends in Parasitology)</DIV>
<DIV> </DIV>
<DIV> </DIV>
<DIV>Regards from France </DIV>
<DIV> </DIV>
<DIV><FONT lang=1 face=Arial size=2 FAMILY="SANSSERIF" PTSIZE="10">Jacques
Lamothe</FONT></DIV></FONT>
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