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<DIV>Dear all</DIV>
<DIV> I would remind that the utilization for dogs of drugs utilized
for humans was forbidden in the last year by federal government.</DIV>
<DIV> Would it be viable to treat thousands of dogs in the huge (and
variable) endemic area of Brazil, which are replaced very quickly? Would
any of us like to have positive dogs being treated in our
neighbourhood?</DIV>
<DIV> </DIV>
<DIV>Best wishes</DIV>
<DIV>Carlos Brisola Marcondes----- Original Message ----- </DIV>
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style="PADDING-RIGHT: 0px; PADDING-LEFT: 5px; MARGIN-LEFT: 5px; BORDER-LEFT: #000000 2px solid; MARGIN-RIGHT: 0px">
<DIV
style="BACKGROUND: #e4e4e4; FONT: 10pt arial; font-color: black"><B>From:</B>
<A title=Jaclamothe@aol.com
href="mailto:Jaclamothe@aol.com">Jaclamothe@aol.com</A> </DIV>
<DIV style="FONT: 10pt arial"><B>To:</B> <A title=killickendrick@wanadoo.fr
href="mailto:killickendrick@wanadoo.fr">killickendrick@wanadoo.fr</A> ; <A
title=leish-l@lineu.icb.usp.br
href="mailto:leish-l@lineu.icb.usp.br">leish-l@lineu.icb.usp.br</A> </DIV>
<DIV style="FONT: 10pt arial"><B>Sent:</B> Monday, April 06, 2009 7:55
PM</DIV>
<DIV style="FONT: 10pt arial"><B>Subject:</B> Re: [Leish-l] Back to
business</DIV>
<DIV><BR></DIV><FONT id=role_document face=Arial color=#000000 size=2>
<DIV>
<DIV>
<DIV>Dans un e-mail daté du 04/04/2009 19:55:11 Paris, Madrid (heure d'été),
<A href="mailto:killickendrick@wanadoo.fr">killickendrick@wanadoo.fr</A> a
écrit :</DIV>
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<DIV>Surely Jacques is not recommending allopuriol alone as treatment? I
seem to remember a study that showed this was not a good idea.</DIV>
<DIV>In France, Glucantime is geverally the answer to CanL with allopurinol
as well. Dogs are not destroyed by law. Medical doctors question the use of
Glucantime because of the risk of drug resustance.</DIV>
<DIV> By the way, 'vaccinated' dogs in Brazil are
presumably seropositive. if so, they should be killed!</DIV>
<DIV> Bob Killick-Kendrick</DIV></FONT></BLOCKQUOTE></DIV>
<DIV></DIV> Allopurinol
alone has a great advantage , the risk of creating resistance transmitted to
humans is neglectable (compared with antimonials or ampho b ) </DIV>
<DIV>Pr Slappedel in Netherland has begun and had good results
(80% long term efficacy) . The paper you mention was published in
99 . It was a comparative study , but in the group allopurinol
alone, dogs were only treated 1 month... (its difficult to make a
clinical studies with dogs belonging to owners) It is for me impossible
to make any conclusion from these results even if it has been
done...</DIV>
<DIV> </DIV>
<DIV>In Greece , Pr Koutinas in a 4 months study has 100% improvement
and 50% of clinical cure . They have also excellent results in the most severe
forms of cl (renal disease) . Gad Baneth uses also this treatment in Israel
</DIV>
<DIV>In the american focus , ive treated and closely followed around 20
dogs (Glucantime was not available , and i didnt want to use
it) and it was a succes. The only problem is that clinical cure is
reached after a longer time than with the classic association Glucantime
allopurinol. But dogs dont go to work on mondays. </DIV>
<DIV> </DIV>
<DIV>There is an emerging consensus in the vet community to avoid the use of
Glucantime and amphotericin B (recent papers of the vet leish group in Trends
in Parasitology)</DIV>
<DIV> </DIV>
<DIV> </DIV>
<DIV>Regards from France </DIV>
<DIV> </DIV>
<DIV><FONT lang=1 face=Arial size=2 PTSIZE="10" FAMILY="SANSSERIF">Jacques
Lamothe</FONT></DIV></FONT>
<P>
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