<html><head></head><BODY bgcolor="#FFFFFF"><p><font size=2 color="#000000" face="Arial">As requested, canine leishmaniasis is very difficult to treat. Most animals dies with the infection in 6 months, despite high-dose glucantime or association with allopurinol. Survivors presented relapses very often, more than 80%. I had no experience with amphotericin, but I suggest that its use will be made at higher doses, associated with Intralipid or other commercial lipid i.v. emulsion in order to diminish toxicity.<br>Heitor Franco de Andrade Jr., M.D., Ph.D.<br>Laboratório de Protozoologia<br>Instituto de Medicina Tropical de São Paulo<br>Av.Dr.E.C.Aguiar, 470<br>05403-000 - São Paulo - SP<br>BRAZIL<br>----------<br>> De: <font color="#0000FF"><u>Jaclamothe@aol.com</u><font color="#000000"><br>> Para: Multiple recipients of list <<font color="#0000FF"><u>leish-l@bdt.org.br</u><font color="#000000">><br>> Assunto: amphotericin<br>> Data: Terça-feira, 10 de Novembro de 1998 22:10<br>> <br>> Id like to have the opinions of epidemiologist and parasitologists about the<br>> treatment of dogs<br>> In france we begin to treat dogs with amphotericine B. Is there a risk for<br>> public healh, with resistances to this drug ( in france human leish is often<br>> associated with aids)<br>> I think that if vet treat dogs correctly the canine reservoir will reduce, and<br>> now a lot of dogs are not treated because classic treatment expensive and<br>> hard to perform ( 2 months with glucantime and 2 to 9 months allopurinol)<br>> <br>> i hope i'll have a lot of opinions<br>> its important for me<br>> <br>> merci<br>> jacques lamothe<br>> vet practicionner<br>> carros<br>> france</p>
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