[Leish-l] Fwd: IL10 & IL-6

Tue Sep 3 13:24:02 -03 2019

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Thank you,

Thiago.

On Tue, Sep 3, 2019 at 12:07 PM Carlos Costa <chncosta at gmail.com> wrote:

> Thanks a lot, Suência. So many excellent explanations but still much more
> things to be explained in this intriguing disease! Cheers, Carlos.
>
> Em qui, 29 de ago de 2019 às 17:03, Suênia Gonçalves <sueniaaa at hotmail.com
> >
> escreveu:
>
> > Dr Carlos,
> >
> > L. infantum infection is strongly associated with the upregulation of Th2
> > cytokines, such as IL-6, IL-13 and IL-10. The polarization of T helper
> > cells depends mainly on the cytokines and co-stimulatory signals provided
> > by antigen-presenting cells for T cell activation. For this regulatory
> > profile the secretion of IL-4 from APCs is determinant. Leishmania
> > lipophosphoglycans induce regulatory cytokine profiles to promote
> > infectivity of the parasites. The mechanisms by which L. infantum (and
> > other species of Leishmania (Leishmania) subgenus, as L. amazonensis)
> > controls the induction of IL-4 (leading to Th2 differentiation) are not
> > fully understood. It is also known that the success of this regulatory
> > induction by the parasite involves interactions between host’s genetics,
> > dose/route of inoculation and/or sandfly saliva components, revealing
> > countless possibilities of APC modulation. Finally, the expression of
> IFNg
> > and IL-10 depends on antagonistic transcription factors on TCD4+ cells
> > (Tbet and GATA3, respectively), thus, low amounts of IFNg are expected in
> > high IL-10 producers (and vice versa). Indeed, it would be simplistic to
> > explain the cytokine secretion on this binary model because there are
> other
> > IL-10 and IFNg cell sources (as Tregs and TCD8+IFNg+, respectively) that
> > are regulated independent on Th1 and Th2 transcription pathways. This
> > should explain the simultaneous presence of icytokines and IL-10 in some
> > situations.
> >
> >
> >
> > *Suênia da C. Gonçalves de Albuquerque*
> > Biomédica, MSc, ScD
> > Laboratório de Endemias - CDZOE/LACEN-PE
> > Dept. de Imunologia - Instituto Aggeu Magalhães, FIOCRUZ-PE
> > ------------------------------
> > *De:* leish-l-bounces at lineu.icb.usp.br <leish-l-bounces at lineu.icb.usp.br
> >
> > em nome de Carlos Costa <chncosta at gmail.com>
> > *Enviado:* sexta-feira, 9 de agosto de 2019 19:46
> > *Para:* Leish-L <Leish-l at lineu.icb.usp.br>
> > *Assunto:* [Leish-l] Fwd: IL10 & IL-6
> >
> > ---------- Forwarded message ---------
> > De: Carlos Costa <chncosta at gmail.com>
> > Date: qui, 8 de ago de 2019 às 08:50
> > Subject: Re: IL10 & IL-6
> > To: Servico de Imunologia <imuno at ufba.br>
> >
> >
> > Thanks, Edgar.
> >
> > Indeed, IL-10 is always present whenever inflammatory cytokines are
> there.
> > But I wonder what are the mechanisms behind this phenomenon. One thought
> > would be that the same stimulus that trigger one icytokine also trigger
> > IL-10 like in one molecule-one receptor-one cytoplasmatic/nuclear pathway
> > model. But this is certainly too simplistic since there are lots of
> > Leishmania molecules and many receptors and the PRR that lead to IL-10
> > apparently are not the same that trigger icytokines.
> >
> > Yes, I understand that nature has provided the immune response with many
> > negative feedback loops in order to prevent exaggerated immune response
> > like it happens in kala-azar and sepsis.
> >
> > Best regards,
> >
> > Carlos.
> >
> > Em qua, 7 de ago de 2019 às 08:51, Servico de Imunologia <imuno at ufba.br>
> > escreveu:
> >
> > > Carlos,
> > >
> > >     It is common the high production of pro-inflamatory cytokines and
> > > anti-inflammatory cytokines as IL-10. In the majorirty of the cases
> IL-10
> > > is produced in an attempt to down modulate the inflammatory response.
> In
> > > the case of visceral leishmaniasis production of IL-10 is induced by
> > > parasite antigens as well pro-inflammatory cytokines.
> > >
> > > Edgar
> > >
> > > ----- Mensagem encaminhada -----
> > > De: "Carlos Costa" <chncosta at gmail.com>
> > > Para: "Leish-L" <Leish-l at lineu.icb.usp.br>
> > > Enviadas: Sábado, 13 de julho de 2019 10:48:40
> > > Assunto: [Leish-l] IL10 & IL-6
> > >
> > > Hi fellows,
> > >
> > > I am trying to understand why in human VL the anti-inflammatory IL-10
> is
> > > systemically strongly expressed together with IL-6, INF-g, and other
> > > pro-inflammatory cytokines.
> > >
> > > I was looking at the mechanisms behind it but found little hints.
> Please
> > > let me know if you have any response for this.
> > >
> > > Thanks a lot,
> > >
> > > Carlos.
> > >
> > > --
> > > Carlos H. N. Costa, MD, DSc.
> > > President
> > > Instituto de Doenças do Sertão
> > > *Instituto de Doenças Tropicais Natan Portella*
> > >
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> >
> > --
> > Carlos H. N. Costa, MD, DSc.
> > President
> > Instituto de Doenças do Sertão
> > *Instituto de Doenças Tropicais Natan Portella*
> >
> > *Centro de Ciências da Saúde da Universidade Federal do Piauí*
> > *Rua Artur de Vasconcelos 151-Sul*
> > *64001-450 Teresina-PI*
> > *Brazil*
> > Telephones: +55 86 3222-4377 (W),
> > +55 86 3221-3062 (W),
> > +55 86 3237-1075 (H).
> >
> >
> > Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS,
> protegidas
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> > please notify us immediately by return e-mail and delete this message
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> > your system.
> >
> >
> > --
> > Carlos H. N. Costa, MD, DSc.
> > President
> > Instituto de Doenças do Sertão
> > *Instituto de Doenças Tropicais Natan Portella*
> >
> > *Centro de Ciências da Saúde da Universidade Federal do Piauí*
> > *Rua Artur de Vasconcelos 151-Sul*
> > *64001-450 Teresina-PI*
> > *Brazil*
> > Telephones: +55 86 3222-4377 (W),
> > +55 86 3221-3062 (W),
> > +55 86 3237-1075 (H).
> >
> >
> > Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS,
> protegidas
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>
>
> --
> Carlos H. N. Costa, MD, DSc.
> President
> Instituto de Doenças do Sertão
> *Instituto de Doenças Tropicais Natan Portella*
>
> *Centro de Ciências da Saúde da Universidade Federal do Piauí*
> *Rua Artur de Vasconcelos 151-Sul*
> *64001-450 Teresina-PI*
> *Brazil*
> Telephones: +55 86 3222-4377 (W),
> +55 86 3221-3062 (W),
> +55 86 3237-1075 (H).
>
>
> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS, protegidas
> pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
> pessoa ou organização para a qual a mensagem foi destinada.
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-- 
Thiago Vieira, PhD

National Institutes of Health,

NIAID, Laboratory of Malaria and Vector Research,

Vector Molecular Biology Section

12735 Twinbrook Parkway 2E-22b

Rockville, MD 20852