[Leish-l] Fwd: IL10 & IL-6

Kleverton Silva klevertonbj at gmail.com
Sat Nov 2 10:26:01 -03 2019


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*Kleverton Ribeiro da Silva*

Em sex, 1 de nov de 2019 às 18:35, Rupashree Sen <rupashree.sen at gmail.com>
escreveu:

> Please remove my email ID from toyr mailing list.
> Thank you,
>
>
> > On Sep 3, 2019, at 12:22 PM, Thiago Vieira <vieira.tssv at gmail.com>
> wrote:
> >
> > Please remove me from your mailing list.
> >
> > Thank you,
> >
> > Thiago.
> >
> >> On Tue, Sep 3, 2019 at 12:07 PM Carlos Costa <chncosta at gmail.com>
> wrote:
> >>
> >> Thanks a lot, Suência. So many excellent explanations but still much
> more
> >> things to be explained in this intriguing disease! Cheers, Carlos.
> >>
> >> Em qui, 29 de ago de 2019 às 17:03, Suênia Gonçalves <
> sueniaaa at hotmail.com
> >>>
> >> escreveu:
> >>
> >>> Dr Carlos,
> >>>
> >>> L. infantum infection is strongly associated with the upregulation of
> Th2
> >>> cytokines, such as IL-6, IL-13 and IL-10. The polarization of T helper
> >>> cells depends mainly on the cytokines and co-stimulatory signals
> provided
> >>> by antigen-presenting cells for T cell activation. For this regulatory
> >>> profile the secretion of IL-4 from APCs is determinant. Leishmania
> >>> lipophosphoglycans induce regulatory cytokine profiles to promote
> >>> infectivity of the parasites. The mechanisms by which L. infantum (and
> >>> other species of Leishmania (Leishmania) subgenus, as L. amazonensis)
> >>> controls the induction of IL-4 (leading to Th2 differentiation) are not
> >>> fully understood. It is also known that the success of this regulatory
> >>> induction by the parasite involves interactions between host’s
> genetics,
> >>> dose/route of inoculation and/or sandfly saliva components, revealing
> >>> countless possibilities of APC modulation. Finally, the expression of
> >> IFNg
> >>> and IL-10 depends on antagonistic transcription factors on TCD4+ cells
> >>> (Tbet and GATA3, respectively), thus, low amounts of IFNg are expected
> in
> >>> high IL-10 producers (and vice versa). Indeed, it would be simplistic
> to
> >>> explain the cytokine secretion on this binary model because there are
> >> other
> >>> IL-10 and IFNg cell sources (as Tregs and TCD8+IFNg+, respectively)
> that
> >>> are regulated independent on Th1 and Th2 transcription pathways. This
> >>> should explain the simultaneous presence of icytokines and IL-10 in
> some
> >>> situations.
> >>>
> >>>
> >>>
> >>> *Suênia da C. Gonçalves de Albuquerque*
> >>> Biomédica, MSc, ScD
> >>> Laboratório de Endemias - CDZOE/LACEN-PE
> >>> Dept. de Imunologia - Instituto Aggeu Magalhães, FIOCRUZ-PE
> >>> ------------------------------
> >>> *De:* leish-l-bounces at lineu.icb.usp.br <
> leish-l-bounces at lineu.icb.usp.br
> >>>
> >>> em nome de Carlos Costa <chncosta at gmail.com>
> >>> *Enviado:* sexta-feira, 9 de agosto de 2019 19:46
> >>> *Para:* Leish-L <Leish-l at lineu.icb.usp.br>
> >>> *Assunto:* [Leish-l] Fwd: IL10 & IL-6
> >>>
> >>> ---------- Forwarded message ---------
> >>> De: Carlos Costa <chncosta at gmail.com>
> >>> Date: qui, 8 de ago de 2019 às 08:50
> >>> Subject: Re: IL10 & IL-6
> >>> To: Servico de Imunologia <imuno at ufba.br>
> >>>
> >>>
> >>> Thanks, Edgar.
> >>>
> >>> Indeed, IL-10 is always present whenever inflammatory cytokines are
> >> there.
> >>> But I wonder what are the mechanisms behind this phenomenon. One
> thought
> >>> would be that the same stimulus that trigger one icytokine also trigger
> >>> IL-10 like in one molecule-one receptor-one cytoplasmatic/nuclear
> pathway
> >>> model. But this is certainly too simplistic since there are lots of
> >>> Leishmania molecules and many receptors and the PRR that lead to IL-10
> >>> apparently are not the same that trigger icytokines.
> >>>
> >>> Yes, I understand that nature has provided the immune response with
> many
> >>> negative feedback loops in order to prevent exaggerated immune response
> >>> like it happens in kala-azar and sepsis.
> >>>
> >>> Best regards,
> >>>
> >>> Carlos.
> >>>
> >>> Em qua, 7 de ago de 2019 às 08:51, Servico de Imunologia <
> imuno at ufba.br>
> >>> escreveu:
> >>>
> >>>> Carlos,
> >>>>
> >>>>    It is common the high production of pro-inflamatory cytokines and
> >>>> anti-inflammatory cytokines as IL-10. In the majorirty of the cases
> >> IL-10
> >>>> is produced in an attempt to down modulate the inflammatory response.
> >> In
> >>>> the case of visceral leishmaniasis production of IL-10 is induced by
> >>>> parasite antigens as well pro-inflammatory cytokines.
> >>>>
> >>>> Edgar
> >>>>
> >>>> ----- Mensagem encaminhada -----
> >>>> De: "Carlos Costa" <chncosta at gmail.com>
> >>>> Para: "Leish-L" <Leish-l at lineu.icb.usp.br>
> >>>> Enviadas: Sábado, 13 de julho de 2019 10:48:40
> >>>> Assunto: [Leish-l] IL10 & IL-6
> >>>>
> >>>> Hi fellows,
> >>>>
> >>>> I am trying to understand why in human VL the anti-inflammatory IL-10
> >> is
> >>>> systemically strongly expressed together with IL-6, INF-g, and other
> >>>> pro-inflammatory cytokines.
> >>>>
> >>>> I was looking at the mechanisms behind it but found little hints.
> >> Please
> >>>> let me know if you have any response for this.
> >>>>
> >>>> Thanks a lot,
> >>>>
> >>>> Carlos.
> >>>>
> >>>> --
> >>>> Carlos H. N. Costa, MD, DSc.
> >>>> President
> >>>> Instituto de Doenças do Sertão
> >>>> *Instituto de Doenças Tropicais Natan Portella*
> >>>>
> >>>> *Centro de Ciências da Saúde da Universidade Federal do Piauí*
> >>>> *Rua Artur de Vasconcelos 151-Sul*
> >>>> *64001-450 Teresina-PI*
> >>>> *Brazil*
> >>>> Telephones: +55 86 3222-4377 (W),
> >>>> +55 86 3221-3062 (W),
> >>>> +55 86 3237-1075 (H).
> >>>>
> >>>>
> >>>> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS,
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> >>>>
> >>>>
> >>>
> >>> --
> >>> Carlos H. N. Costa, MD, DSc.
> >>> President
> >>> Instituto de Doenças do Sertão
> >>> *Instituto de Doenças Tropicais Natan Portella*
> >>>
> >>> *Centro de Ciências da Saúde da Universidade Federal do Piauí*
> >>> *Rua Artur de Vasconcelos 151-Sul*
> >>> *64001-450 Teresina-PI*
> >>> *Brazil*
> >>> Telephones: +55 86 3222-4377 (W),
> >>> +55 86 3221-3062 (W),
> >>> +55 86 3237-1075 (H).
> >>>
> >>>
> >>> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS,
> >> protegidas
> >>> pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
> >>> pessoa ou organização para a qual a mensagem foi destinada.
> >>> Warning: This message is meant only for the intended recipient of the
> >>> transmission.  It is forbidden any unauthorized use, alteration,
> >>> reproduction, and distribution. If you are not the correct recipient,
> >>> please notify us immediately by return e-mail and delete this message
> >> from
> >>> your system.
> >>>
> >>>
> >>> --
> >>> Carlos H. N. Costa, MD, DSc.
> >>> President
> >>> Instituto de Doenças do Sertão
> >>> *Instituto de Doenças Tropicais Natan Portella*
> >>>
> >>> *Centro de Ciências da Saúde da Universidade Federal do Piauí*
> >>> *Rua Artur de Vasconcelos 151-Sul*
> >>> *64001-450 Teresina-PI*
> >>> *Brazil*
> >>> Telephones: +55 86 3222-4377 (W),
> >>> +55 86 3221-3062 (W),
> >>> +55 86 3237-1075 (H).
> >>>
> >>>
> >>> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS,
> >> protegidas
> >>> pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
> >>> pessoa ou organização para a qual a mensagem foi destinada.
> >>> Warning: This message is meant only for the intended recipient of the
> >>> transmission.  It is forbidden any unauthorized use, alteration,
> >>> reproduction, and distribution. If you are not the correct recipient,
> >>> please notify us immediately by return e-mail and delete this message
> >> from
> >>> your system.
> >>> _______________________________________________
> >>> Leish-l mailing list
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> >>>
> >>> --
> >>> This email was sent by icb.usp.br
> >>>
> >>
> >>
> >> --
> >> Carlos H. N. Costa, MD, DSc.
> >> President
> >> Instituto de Doenças do Sertão
> >> *Instituto de Doenças Tropicais Natan Portella*
> >>
> >> *Centro de Ciências da Saúde da Universidade Federal do Piauí*
> >> *Rua Artur de Vasconcelos 151-Sul*
> >> *64001-450 Teresina-PI*
> >> *Brazil*
> >> Telephones: +55 86 3222-4377 (W),
> >> +55 86 3221-3062 (W),
> >> +55 86 3237-1075 (H).
> >>
> >>
> >> Aviso: As informações contidas nesta mensagem são CONFIDENCIAIS,
> protegidas
> >> pelo sigilo legal, por direitos autorais e destinadas exclusivamente à
> >> pessoa ou organização para a qual a mensagem foi destinada.
> >> Warning: This message is meant only for the intended recipient of the
> >> transmission.  It is forbidden any unauthorized use, alteration,
> >> reproduction, and distribution. If you are not the correct recipient,
> >> please notify us immediately by return e-mail and delete this message
> from
> >> your system.
> >> _______________________________________________
> >> Leish-l mailing list
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> >>
> >> --
> >> This email was sent by icb.usp.br
> >>
> > --
> > Thiago Vieira, PhD
> >
> > National Institutes of Health,
> >
> > NIAID, Laboratory of Malaria and Vector Research,
> >
> > Vector Molecular Biology Section
> >
> > 12735 Twinbrook Parkway 2E-22b
> >
> > Rockville, MD 20852
> > _______________________________________________
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> >
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