[Leish-l] testing vaccinated dogs for immunopotentiation
John David
jdavid at hsph.harvard.edu
Mon Sep 26 18:43:48 BRT 2011
I think that for any vaccine developed to protect dogs against VL, but
which is also meant to prevent transmission of VL to humans, the
developers should show that after the vaccinated dog has been
challenged with Leishmania, it does not transmit Leishmania to sand
flies.
John R David, M.D.
Richard Pearson Strong Professor Emeritus
Department of Immunology and Infectious Diseases
Harvard School of Public Health
Professor of Medicine, Harvard Medical School
300 W. 23rd Street, Apt. 13K
New York, NY, 10011
Tel: 212 414 8646
Email: jdavid at hsph.harvard.edu
On Sep 19, 2011, at 12:04 AM, Dr GR Rajasekariah wrote:
> Hello EveryOne,
> I am responding to the topic on European VL Dog vaccine.
> It is a great challenge in devising a protective vaccine against
> visceral leishmaniasis in dogs. This point equally applies the same
> challenge for human situation.
> Because Th-2 response is so dominant during VL infection, modulating
> Th-2 into Th-1 response is a big challenge to immunologists.
>
> Key points lies in the presentation of appropriate antigen in
> appropriate dose to stimulate the Th-1 dependent protective immune
> response.
> I understand several vaccines are in the market and real efficacy of
> these vaccines will come out once introduced to field conditions.
>
> I just wanted to inform you that we have a suitable antibody kit
> for testing the immunopotentiation in dogs following vaccination of
> dogs.
> Our assay is based on the released promastigote antigens.
> It is a highly sensitive assay.
> Currently we supply reagents for determination of total IgG
> antibodies in serum.
> If any particular group is interested then we are able to provide
> appropriate reagent for detection of specific IgG2 and other isotype
> specific antibody detection.
> Because our antibody detection ELISA is based on the exo-antigens
> such an ELISA would be of exceptional type for measuring antibody
> response in vaccinated animals.
> Highly suitable for diagnosing dogs responded to vaccines.
>
> Recently I came to know that some of commercial kits were found to
> be not useful for detecting seroconversion in dogs vaccinated with
> FML vaccine (Leish-Immune) in Brazil.
> Because we use released antigens in our kit, any such problems will
> overcome if they use Canine Leish IgG CELISA (Manufacturer Cellabs
> Pty Ltd Brookvale NSW Australia email sales at cellabs.com.au).
> If any one is interested to know more about our antibody detection
> ELISA based on exo-antigens please contact us.
>
> This is for your kind information.
>
> Dr GR Rajasekariah
> Sydney
> Australia
> raj at cellabs.com.au
>
>
>
>
>
>
> ----- Original Message ----- From: <leish-l-request at lineu.icb.usp.br>
> To: <leish-l at lineu.icb.usp.br>
> Sent: Wednesday, August 10, 2011 5:18 PM
> Subject: Leish-l Digest, Vol 44, Issue 3
>
>
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>> Today's Topics:
>>
>> 1. European VL Dog Vaccine - CaniLeish?: (jeffrey shaw)
>> 2. Re: FW: Leishmaniasis Pathology Network (Moazzem Hossain)
>> 3. Re: FW: Leishmaniasis Pathology Network (Moazzem Hossain)
>>
>>
>> ----------------------------------------------------------------------
>>
>> Message: 1
>> Date: Tue, 9 Aug 2011 15:18:44 +0000
>> From: jeffrey shaw <jayusp at hotmail.com>
>> Subject: [Leish-l] European VL Dog Vaccine - CaniLeish?:
>> To: Leish-L <leish-l at lineu.icb.usp.br>
>> Message-ID: <COL101-W1CDD4171D44B715B795E9CB200 at phx.gbl>
>> Content-Type: text/plain; charset="windows-1252"
>>
>>
>> CaniLeish?:
>> The European Commission granted a marketing authorisation valid
>> throughout the European Union, for CaniLeish to Virbac S.A. on
>> 14/03/2011.
>> This vaccine, CaniLeish?, will initially be launched in Portugal
>> at the end of the first half of 2011. This will be followed rapidly
>> by launches in other countries in the endemic area: Spain, France,
>> Greece and Italy (not in chronological order). This roll-out takes
>> account of the geographical prevalence of the disease and the time
>> required to build vaccine production up to full capacity. The
>> launch in Northern European countries from where there is a flow of
>> summer visitors to the endemic area will be part of a second phase.
>> The basis of this vaccine are excreted proteins plus a saponin
>> adjuvant purified from Quil-A. Its efficacy was determined in a 2
>> year open field trial.
>> The vaccine is given to dogs as three injections, three weeks
>> apart, under the skin. The first injection can be given from six
>> months of age, the second injection is given three weeks later and
>> the third three weeks from the second one. Afterward a single ?
>> booster? should be given every year to maintain protection.
>> -------------- next part --------------
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>> >
>>
>> ------------------------------
>>
>> Message: 2
>> Date: Wed, 10 Aug 2011 13:07:17 +0600
>> From: Moazzem Hossain <directordcbd at gmail.com>
>> Subject: Re: [Leish-l] FW: Leishmaniasis Pathology Network
>> To: jeffrey shaw <jayusp at hotmail.com>, "Prof. Paul Kaye"
>> <paul.kaye at york.ac.uk>
>> Cc: "Prof. Dr. Moazzem Hossain" <profdrmoazzemhossain at gmail.com>,
>> Leish-L <leish-l at lineu.icb.usp.br>
>> Message-ID:
>> <CAE-TCmS=i=WaT8cAeOXUJmot=KPvMQSLKar6CTfuUBK9M9tsUw at mail.gmail.com>
>> Content-Type: text/plain; charset=windows-1252
>>
>> 10 Aug 2011
>>
>> Dear Professor Paul Kaye,
>>
>> Thank you for your email. Please find attached our supportive letter
>> of interest for Leishmaniasis Pathology Network.
>> Looking forward for your kind response.
>>
>> Best regards.
>>
>>
>> --
>> *Prof. Dr. Moazzem Hossain *
>> Ex - Director Disease Control
>> Ministry of Health & Family Welfare
>> Government of Bangladesh
>> *Mailing address*:
>> Founder Chairman and Project Director
>> Institute of Allergy & Clinical Immunology of Bangladesh (IACIB)
>> Room 4 - 5 (2nd Floor), Green Super Market, Green Road
>> Dhaka -1205, Bangladesh.
>> Phone:880-2-8115646 (O )
>> 880-1715038551(Mobile)
>> Email: directordcbd at gmail.com
>>
>>
>>
>>
>>
>>
>>
>>
>> On 8/9/11, jeffrey shaw <jayusp at hotmail.com> wrote:
>>>
>>>
>>>
>>> Date: Tue, 9 Aug 2011 11:58:52 +0100
>>> From: paul.kaye at york.ac.uk
>>>
>>> Subject: Leishmaniasis Pathology Network
>>>
>>>
>>>
>>>
>>>
>>>
>>>
>>>
>>>
>>> Dear all,
>>> Invitation to participate in a global pathology
>>> network for
>>> research and training in leishmaniasis (LeishPathNet)
>>> You may recall the Dormy House meeting in 2008
>>> and some of
>>> the plans we put forward? Over
>>> the past
>>> couple years, I have also spoken more to a few of you about one
>>> idea that was
>>> formulated at Dormy, namely of setting up a digital pathology
>>> network. I have
>>> also had numerous discussions with the major equipment
>>> manufacturers to see if
>>> any of them would be supportive of helping us to develop such
>>> an
>>> initiative. There have
>>> been two major
>>> develoments recently. First,
>>> Carl Zeiss
>>> is willing to work with us to set up an integrated global
>>> digital
>>> pathology
>>> network (providing a significant financial and technical
>>> contribution) and
>>> second, the Wellcome Trust is willing to review a pre-
>>> proposal to
>>> fund the
>>> initiative through their new Biomedical Resources Grant scheme
>>> (http://www.wellcome.ac.uk/Funding/Biomedical-science/Funding-schemes/Strategic-awards-and-initiatives/wtdv031727.htm
>>> )
>>> .
>>> I have attached an outline of the project that
>>> I had sent to
>>> the Trust for their initial views, which I think is reasonably
>>> self-explanatory.
>>> They appeared very
>>> enthusiastic! The main
>>> question now is whether enough of
>>> you are still supportive? [ I will also be sending this email
>>> to
>>> others, but please feel free to circulate ]
>>>
>>>
>>> I think the
>>> project will be
>>> challenging, but success could have a real impact on the
>>> way we
>>> conduct
>>> business. It should serve not only as a vehicle to enhance
>>> research in
>>> leishmaniasis, but the model would be equally applicable
>>> across
>>> a broad range
>>> of diseases and global challenges (with leishmaniasis setting
>>> the pace).
>>> If we wish to
>>> proceed, the requirements
>>> are that we submit a pre-proposal to the Trust by Oct 18th
>>> 2011.
>>> This pre-proposal is short (4 sections of 350 words) and
>>> requires
>>> letters of support from the community.
>>> If you are
>>> supportive of the idea that
>>> we try to take this forward (and there is plenty of scope for
>>> later iteration
>>> of the detail), I would be grateful if you could please
>>> provide
>>> me with a
>>> letter of support by September
>>> 12th
>>> 2011, indicating whether you would like to be a network
>>> partner if the bid
>>> is successful. You could
>>> also be
>>> supportive but not wish to become directly involved at this
>>> stage, and such
>>> letters are equally valuable. Your letter might also stress
>>> the
>>> added value
>>> that the network could provide, its importance for research
>>> and
>>> training and/or
>>> for progressing the translational agenda.
>>> It would also be an opportunity to indicate whether your
>>> group (or
>>> institute, if multiple groups) would be interested in
>>> bidding to
>>> be one of the
>>> initial ?designated laboratories?.
>>> If there is
>>> sufficient support to
>>> proceed and if subsequently the pre-proposal is successful
>>> (we
>>> will know on 22nd
>>> Nov), then I will need a few volunteers to help finalise the
>>> full proposal,
>>> which will be due on Jan 26th 2012.
>>> A funding decision will be made on May 26th
>>> 2012.
>>> Best wishes
>>> and of course I am happy to
>>> discuss any points further (though I will be out of the UK
>>> from
>>> Aug 10 ?Sept
>>> 12)
>>> Paul
>>>
>>>
>>>
>>>
>>>
>>>
>>>
>>> --
>>> Professor Paul Kaye, Ph.D., FRCPath.
>>> Deputy Dean (Research), Hull York Medical School, and
>>> Director, Centre for Immunology and Infection
>>> Department of Biology and Hull York Medical School
>>> University of York
>>> Wentworth Way
>>> York YO10 5YW
>>> United Kingdom
>>>
>>> Tel: +44 (0)1904 328840
>>> Fax: +44 (0)1904 328844
>>> Email: paul.kaye at york.ac.uk <mailto:paul.kaye at york.ac.uk>
>>>
>>> Centre Administrator and PA: Elizabeth Greensted
>>> Tel: 01904 328845
>>> Email: liz.greensted at york.ac.uk <mailto:liz.greensted at york.ac.uk>
>>>
>>> Centre Email: cii at york.ac.uk <mailto:cii at york.ac.uk>
>>>
>>> Centre website: http://www.york.ac.uk/cii
>>>
>>> Times Higher Education University of the Year 2010
>>>
>>> Email disclaimer: http://www.york.ac.uk/docs/disclaimer/email.htm
>>>
>>>
>>
>>
>> ------------------------------
>>
>> Message: 3
>> Date: Wed, 10 Aug 2011 13:06:47 +0600
>> From: Moazzem Hossain <directordcbd at gmail.com>
>> Subject: Re: [Leish-l] FW: Leishmaniasis Pathology Network
>> To: jeffrey shaw <jayusp at hotmail.com>, "Prof. Paul Kaye"
>> <paul.kaye at york.ac.uk>
>> Cc: "Prof. Dr. Moazzem Hossain" <profdrmoazzemhossain at gmail.com>,
>> Leish-L <leish-l at lineu.icb.usp.br>
>> Message-ID:
>> <CAE-TCmQNUkZdNE5w+Z20bjLC-=vvV9BCP6OLOm9f6RV-BfpXvA at mail.gmail.com>
>> Content-Type: text/plain; charset="windows-1252"
>>
>> 10 Aug 2011
>>
>> Dear Professor Paul Kaye,
>>
>> Thank you for your email. Please find attached our supportive letter
>> of interest for Leishmaniasis Pathology Network.
>> Looking forward for your kind response.
>>
>> Best regards.
>>
>>
>> --
>> *Prof. Dr. Moazzem Hossain *
>> Ex - Director Disease Control
>> Ministry of Health & Family Welfare
>> Government of Bangladesh
>> *Mailing address*:
>> Founder Chairman and Project Director
>> Institute of Allergy & Clinical Immunology of Bangladesh (IACIB)
>> Room 4 - 5 (2nd Floor), Green Super Market, Green Road
>> Dhaka -1205, Bangladesh.
>> Phone:880-2-8115646 (O )
>> 880-1715038551(Mobile)
>> Email: directordcbd at gmail.com
>>
>>
>>
>>
>>
>>
>>
>>
>> On 8/9/11, jeffrey shaw <jayusp at hotmail.com> wrote:
>>>
>>>
>>>
>>> Date: Tue, 9 Aug 2011 11:58:52 +0100
>>> From: paul.kaye at york.ac.uk
>>>
>>> Subject: Leishmaniasis Pathology Network
>>>
>>>
>>>
>>>
>>>
>>>
>>>
>>>
>>>
>>> Dear all,
>>> Invitation to participate in a global pathology
>>> network for
>>> research and training in leishmaniasis (LeishPathNet)
>>> You may recall the Dormy House meeting in 2008
>>> and some of
>>> the plans we put forward? Over
>>> the past
>>> couple years, I have also spoken more to a few of you about one
>>> idea that was
>>> formulated at Dormy, namely of setting up a digital pathology
>>> network. I have
>>> also had numerous discussions with the major equipment
>>> manufacturers to see if
>>> any of them would be supportive of helping us to develop such
>>> an
>>> initiative. There have
>>> been two major
>>> develoments recently. First,
>>> Carl Zeiss
>>> is willing to work with us to set up an integrated global
>>> digital
>>> pathology
>>> network (providing a significant financial and technical
>>> contribution) and
>>> second, the Wellcome Trust is willing to review a pre-
>>> proposal to
>>> fund the
>>> initiative through their new Biomedical Resources Grant scheme
>>> (http://www.wellcome.ac.uk/Funding/Biomedical-science/Funding-schemes/Strategic-awards-and-initiatives/wtdv031727.htm
>>> )
>>> .
>>> I have attached an outline of the project that
>>> I had sent to
>>> the Trust for their initial views, which I think is reasonably
>>> self-explanatory.
>>> They appeared very
>>> enthusiastic! The main
>>> question now is whether enough of
>>> you are still supportive? [ I will also be sending this email
>>> to
>>> others, but please feel free to circulate ]
>>>
>>>
>>> I think the
>>> project will be
>>> challenging, but success could have a real impact on the
>>> way we
>>> conduct
>>> business. It should serve not only as a vehicle to enhance
>>> research in
>>> leishmaniasis, but the model would be equally applicable
>>> across
>>> a broad range
>>> of diseases and global challenges (with leishmaniasis setting
>>> the pace).
>>> If we wish to
>>> proceed, the requirements
>>> are that we submit a pre-proposal to the Trust by Oct 18th
>>> 2011.
>>> This pre-proposal is short (4 sections of 350 words) and
>>> requires
>>> letters of support from the community.
>>> If you are
>>> supportive of the idea that
>>> we try to take this forward (and there is plenty of scope for
>>> later iteration
>>> of the detail), I would be grateful if you could please
>>> provide
>>> me with a
>>> letter of support by September
>>> 12th
>>> 2011, indicating whether you would like to be a network
>>> partner if the bid
>>> is successful. You could
>>> also be
>>> supportive but not wish to become directly involved at this
>>> stage, and such
>>> letters are equally valuable. Your letter might also stress
>>> the
>>> added value
>>> that the network could provide, its importance for research
>>> and
>>> training and/or
>>> for progressing the translational agenda.
>>> It would also be an opportunity to indicate whether your
>>> group (or
>>> institute, if multiple groups) would be interested in
>>> bidding to
>>> be one of the
>>> initial ?designated laboratories?.
>>> If there is
>>> sufficient support to
>>> proceed and if subsequently the pre-proposal is successful
>>> (we
>>> will know on 22nd
>>> Nov), then I will need a few volunteers to help finalise the
>>> full proposal,
>>> which will be due on Jan 26th 2012.
>>> A funding decision will be made on May 26th
>>> 2012.
>>> Best wishes
>>> and of course I am happy to
>>> discuss any points further (though I will be out of the UK
>>> from
>>> Aug 10 ?Sept
>>> 12)
>>> Paul
>>>
>>>
>>>
>>>
>>>
>>>
>>>
>>> --
>>> Professor Paul Kaye, Ph.D., FRCPath.
>>> Deputy Dean (Research), Hull York Medical School, and
>>> Director, Centre for Immunology and Infection
>>> Department of Biology and Hull York Medical School
>>> University of York
>>> Wentworth Way
>>> York YO10 5YW
>>> United Kingdom
>>>
>>> Tel: +44 (0)1904 328840
>>> Fax: +44 (0)1904 328844
>>> Email: paul.kaye at york.ac.uk <mailto:paul.kaye at york.ac.uk>
>>>
>>> Centre Administrator and PA: Elizabeth Greensted
>>> Tel: 01904 328845
>>> Email: liz.greensted at york.ac.uk <mailto:liz.greensted at york.ac.uk>
>>>
>>> Centre Email: cii at york.ac.uk <mailto:cii at york.ac.uk>
>>>
>>> Centre website: http://www.york.ac.uk/cii
>>>
>>> Times Higher Education University of the Year 2010
>>>
>>> Email disclaimer: http://www.york.ac.uk/docs/disclaimer/email.htm
>>>
>>>
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