[Leish-l] RES: testing vaccinated dogs for immunopotentiation
Patrick Bastien
patrick.bastien at univ-montp1.fr
Sat Oct 22 09:22:18 BRST 2011
In any case, even if one rare case was proven (of which I doubt
greatly, unless the chils has an open and fresh wound), this type of
tranmsission would not have the least epidemiological significance.
Regards
P. Bastien
"Chang, Kwang-Poo" <KwangPoo.Chang at rosalindfranklin.edu> a écrit :
> Carlos Costa brought my attention to this possibility as well.
> Carlos may want to comment on this ? Is this a hypothesis based on
> common sense or on observation/experimental data ?
>
> KP
>
> -----Original Message-----
> From: leish-l-bounces at lineu.icb.usp.br
> [mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of
> mauro.marzochi at ipec.fiocruz.br
> Sent: Wednesday, October 19, 2011 2:26 PM
> To: leish-l at lineu.icb.usp.br
> Subject: Re: [Leish-l] RES: testing vaccinated dogs for immunopotentiation
>
> Dear All,
> In the past, it was believed that in the Mediterranean region the
> visceral leishmaniasis transmission to children could be attributed to
> contamination of healthy children by the saliva of dogs infected with
> Leishmania infantum (Alencar?; Hommel?). Thus, the inter canine
> transmission in confined environments could not be established by the
> contamination of food shared between infected and uninfected dogs?
>
> Mauro C A Marzochi
> IPEC-Fiocruz/CNPq
>
>
>
>
>
> On Wed, 19 Oct 2011 08:25:45 -0500, Petersen, Christine A [V PTH]
> wrote:
>> Dear all-
>> Thanks for the review. Vertical infection is maintaining infection
>> in dogs in the United States. We continue to look for vector
>> transmission, and despite having potential sand fly vectors, no
>> infected flies to date.
>> Christy Petersen
>> -----Original Message-----
>> From: leish-l-bounces at lineu.icb.usp.br
>> [mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Courtenay,
>> Orin
>> Sent: Wednesday, October 19, 2011 3:46 AM
>> To: leish-l at lineu.icb.usp.br; jayusp at hotmail.com
>> Subject: Re: [Leish-l] RES: testing vaccinated dogs for
>> immunopotentiation
>>
>> Dear all,
>> I attach a recent review of evidence for non-sandfly transmission
>> routes and cycles in different hosts.
>>
>> It is worth distinguishing between vaccination outcomes: one that
>> provides individual protection versus one that provides community
>> protection (herd immunity) by interrupting the transmission cycle
>> (R0<1). The attached review concludes that vertical infection is very
>> unlikely to maintain transmission independent of the dog-sandfly-dog
>> cycle.
>>
>> Orin
>>
>>
>> Dr. Orin Courtenay
>> Reader
>> School of Life Sciences
>> University of Warwick
>> Gibbet Hill Road
>> Coventry
>> CV4 7AL
>> ++44 +2476 524550
>> skype: orin.courtenay
>> orin.courtenay at warwick.ac.uk
>> http://www2.warwick.ac.uk/fac/sci/lifesci/people/ocourtenay/
>>
>> Emails over 10Mb will not reach me. If you want to send large files
>> use the following: https://files.warwick.ac.uk/orincourtenay/sendto
>>
>>
>>
>> -----Original Message-----
>> From: leish-l-bounces at lineu.icb.usp.br
>> [mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Chang,
>> Kwang-Poo
>> Sent: 17 October 2011 18:54
>> To: Patrick Bastien; leish-l at lineu.icb.usp.br
>> Subject: Re: [Leish-l] RES: testing vaccinated dogs for
>> immunopotentiation
>>
>> Dear Patrick,
>>
>> Thanks a lot for the article from Brazil about vertical transmission
>> of canine leishmaniasis. The work is significant and was done by
>> examining stillborn pups.
>>
>> Christy's recent paper extended this and the other earlier finding of
>> Leishmania in fetus to live pups. Together, they constitute strong
>> evidence for vertical transmission of Leishmania in dogs. As pointed
>> out in the article, its potential significance in epidemiology awaits
>> further study. This is also true for its implication in considering
>> vaccination, etc.
>>
>> KP
>>
>>
>>
>> -----Original Message-----
>> From: leish-l-bounces at lineu.icb.usp.br
>> [mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Patrick
>> Bastien
>> Sent: Saturday, October 15, 2011 3:13 AM
>> To: leish-l at lineu.icb.usp.br
>> Subject: Re: [Leish-l] RES: testing vaccinated dogs for
>> immunopotentiation
>>
>> Dear KP,
>> That's it for article [3].
>> (don't ask me how I got this proof, I cant' remember).
>> Best wishes
>> P. Bastien
>>
>> Professeur Patrick Bastien
>> Laboratoire de Parasitologie-Mycologie, Faculté de Médecine UMR
>> MIVEGEC (CNRS 5290 - IRD 224 - Université Montpellier 1) Centre
>> National de Référence des Leishmania CHU de Montpellier
>> 39 Avenue Charles Flahault
>> 34295 Montpellier Cedex 5, France
>>
>> "Chang, Kwang-Poo" <KwangPoo.Chang at rosalindfranklin.edu> a écrit :
>>
>>> I also recall the description of sexual transmission in human
>>> leishmaniasis in old literature, but this is rare.
>>>
>>>
>>> Going back to the issue of congenital transmission in human and
>>> canine leishmaiasis, I listed 3 articles below from a pubmed search.
>>>
>>> [1] Pediatrics. 1999 Nov;104(5):e65.
>>> Congenital transmission of visceral leishmaniasis (Kala Azar) from
>>> an asymptomatic mother to her child.
>>> Meinecke CK, Schottelius J, Oskam L, Fleischer B.
>>> SourceChildren's Hospital of Stuttgart (Olgahospital), Stuttgart,
>>> Germany.
>>>
>>>
>>>
>>> [2] J Parasitol. 2005 Aug;91(4):970-2.
>>> Transplacental transmission of a North American isolate of
>>> Leishmania infantum in an experimentally infected beagle.
>>> Rosypal AC, Troy GC, Zajac AM, Frank G, Lindsay DS.
>>> SourceDepartment of Biomedical Sciences and Pathobiology,
>>> Virginia-Maryland Regional College of Veterinary Medicine, Virginia
>>> Tech, Blacksburg, Virginia 24061, USA
>>>
>>> [3] Vet Parasitol. 2009 Dec 3;166(1-2):159-62. Epub 2009 Aug 15.
>>> First report of vertical transmission of Leishmania (Leishmania)
>>> infantum in a naturally infected bitch from Brazil.
>>> da Silva SM, Ribeiro VM, Ribeiro RR, Tafuri WL, Melo MN, Michalick
>>> MS.
>>> SourceDepartamento de Parasitologia, Instituto de Ciências
>>> Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo
>>> Horizonte, MG, Brazil.
>>>
>>> I hope Dr. Rosypal and the authors of article [3] could make the pdf
>>> reprints of their articles available, since they were published in
>>> journals, which are not readily available.
>>>
>>>
>>>
>>> KP
>>>
>>> -----Original Message-----
>>> From: leish-l-bounces at lineu.icb.usp.br
>>> [mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Christopher
>>> Peacock
>>> Sent: Sunday, October 09, 2011 10:33 PM
>>> To: leish-l at lineu.icb.usp.br
>>> Subject: Re: [Leish-l] RES: testing vaccinated dogs for
>>> immunopotentiation
>>>
>>> Hi,
>>> There is also this rather bizarre story of a Gulf War veteran who
>>> returned with leishmaniasis, this link is a Veterans association
>>> website and suggest both sexual transmission and vertical
>>> transmission. Not sure how reliable this information is but it does
>>> seem to be contested in court. Would be interesting to know more
>>> details on this case and whether it has any evidence to support the
>>> cases, as far as I am aware there has only been one suggested case
>>> of sexually transmitted Leishmania in humans documented many years
>>> ago.
>>>
>>> http://www.vawatchdog.org/07/nf07/nfJUN07/nf062907-3.htm
>>>
>>> http://www.leishmaniasis.us/Leish.html
>>>
>>> Cheers
>>>
>>> Chris
>>>
>>> Associate Professor Christopher Peacock
>>> Discipline of Microbiology & Immunology M502
>>> School of Biomedical, Biomolecular & Chemical Sciences
>>> The University of Western Australia
>>> Nedlands WA 6009
>>>
>>> ph 00 61(0)8 9287 6172
>>> fax 00 61(0)8 9346 2912
>>>
>>> -----Original Message-----
>>> From: leish-l-bounces at lineu.icb.usp.br
>>> [mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Patrick
>>> Bastien
>>> Sent: Saturday, 8 October 2011 1:31 AM
>>> To: leish-l at lineu.icb.usp.br
>>> Subject: Re: [Leish-l] RES: testing vaccinated dogs for
>>> immunopotentiation
>>>
>>> There were several earlier reports of this vertical transmission,
>>> even
>>> in the US: among others, Rosypal AC, J.Parasitol. 2005, 970-972 and
>>> 113-115 Magno da Silva, Vet Parasitol 2009 Pangrazio, Vet Parasitol
>>> 2009
>>>
>>> Best regards
>>> P. Bastien
>>>
>>> Professeur Patrick Bastien
>>> Laboratoire de Parasitologie-Mycologie, Faculté de Médecine UMR
>>> MIVEGEC (CNRS 5290 - IRD 224 - Université Montpellier 1) Centre
>>> National de Référence des Leishmania CHU de Montpellier
>>> 39 Avenue Charles Flahault
>>> 34295 Montpellier Cedex 5, France
>>>
>>> "Chang, Kwang-Poo" <KwangPoo.Chang at rosalindfranklin.edu> a écrit :
>>>
>>>> What Jenni said indicates that transplacental transmission of
>>>> canine
>>>> leishmaniasis has some implication in considering dog vaccination.
>>>>
>>>>
>>>>
>>>> Of further interest is the question of whether this transplacental
>>>> transmission could also occur in other reservoir animals or even in
>>>> human leishmaniasis ? I recall the description of such transmission
>>>> in human cases in some very early literature, but that has been
>>>> always considered as unlikely or extremely rare, more as a
>>>> hypothesis
>>>> than reality. This issue may have been addressed in more recent
>>>> epidemiological studies of VL familial clustering in
>>>> well-established
>>>> endemic sites ? Congenital transmission might escape our attention,
>>>> should the outcome be largely asymptomatic ?
>>>>
>>>>
>>>>
>>>> KP
>>>>
>>>>
>>>>
>>>> ________________________________
>>>>
>>>> From: Jennie Blackwell [mailto:jmb37 at cam.ac.uk]
>>>> Sent: Wednesday, October 05, 2011 6:46 PM
>>>> To: Chang, Kwang-Poo
>>>> Cc: Petersen, Christine A [V PTH]; TECSA - Luiz Ristow; John David;
>>>> leish-l at lineu.icb.usp.br
>>>> Subject: Re: [Leish-l] RES: testing vaccinated dogs for
>>>> immunopotentiation
>>>>
>>>>
>>>>
>>>> I doubt it. Treatment might but if the mum was already infected and
>>>> passed the parasite to the foetus I don't see how a vaccine would
>>>> work to clear the parasite from the foetus!
>>>>
>>>>
>>>>
>>>> Slightly different question as to whether vaccinating mums will
>>>> give
>>>> them sufficient protection to not pass the parasite to the pup in
>>>> utero should they get infected themselves after vaccination.
>>>>
>>>>
>>>>
>>>> Cheers all, Jennie
>>>>
>>>> Jenefer M. Blackwell
>>>>
>>>> TICHR, CCHR, UWA
>>>>
>>>> Phone: +61 8 94897910
>>>>
>>>> From my iPhone
>>>>
>>>>
>>>> On 29 Sep 2011, at 00:36, "Chang, Kwang-Poo"
>>>> <KwangPoo.Chang at rosalindfranklin.edu> wrote:
>>>>
>>>> Of interest is the question of whether vaccination would
>>>> clear
>>>> the infection of the pub, which has congenitally inherited L
>>>> infantum ?
>>>>
>>>>
>>>>
>>>> KP
>>>>
>>>>
>>>>
>>>>
>>>> ________________________________
>>>>
>>>>
>>>> From: Petersen, Christine A [V PTH]
>>>> [mailto:kalicat at iastate.edu]
>>>>
>>>> Sent: Wednesday, September 28, 2011 11:23 AM
>>>> To: Chang, Kwang-Poo; TECSA - Luiz Ristow; John David
>>>> Cc: leish-l at lineu.icb.usp.br; Petersen, Christine A [V PTH]
>>>> Subject: RE: [Leish-l] RES: testing vaccinated dogs for
>>>> immunopotentiation
>>>>
>>>>
>>>>
>>>> The reference for this article is:
>>>> <http://www.ncbi.nlm.nih.gov/pubmed/21532741>
>>>> http://www.ncbi.nlm.nih.gov/pubmed/21532741
>>>>
>>>> As it was published in a PLoS journal its free access to all.
>>>>
>>>> Based on our studies and recent ones from Brazil, I do
>>>> believe
>>>> that to remove Leish from the canine reservoir, transmission from
>>>> mom
>>>> to pup will need to be addressed.
>>>>
>>>> Christy Petersen
>>>>
>>>>
>>>>
>>>> From: Chang, Kwang-Poo
>>>> [mailto:KwangPoo.Chang at rosalindfranklin.edu]
>>>> Sent: Wednesday, September 28, 2011 10:20 AM
>>>> To: TECSA - Luiz Ristow; John David
>>>> Cc: leish-l at lineu.icb.usp.br; Petersen, Christine A [V PTH]
>>>> Subject: RE: [Leish-l] RES: testing vaccinated dogs for
>>>> immunopotentiation
>>>>
>>>>
>>>>
>>>> Christine Petersen published an article about transplacental
>>>> transmission of L infantum in the USA canine leishmaniasis. I just
>>>> wonder about the implication of this finding in considering
>>>> vaccination against the disease transmitted this way ?
>>>>
>>>>
>>>>
>>>> KP
>>>>
>>>>
>>>>
>>>>
>>>> ________________________________
>>>>
>>>>
>>>> From: <mailto:leish-l-bounces at lineu.icb.usp.br>
>>>> leish-l-bounces at lineu.icb.usp.br
>>>> [mailto:leish-l-bounces at lineu.icb.usp.br]
>>>> <mailto:%5bmailto:leish-l-bounces at lineu.icb.usp.br%5d> On Behalf
>>>> Of
>>>> TECSA - Luiz Ristow
>>>> Sent: Wednesday, September 28, 2011 9:08 AM
>>>> To: 'John David'
>>>> Cc: <mailto:leish-l at lineu.icb.usp.br>
>>>> leish-l at lineu.icb.usp.br
>>>> Subject: [Leish-l] RES: testing vaccinated dogs for
>>>> immunopotentiation
>>>>
>>>>
>>>>
>>>> Hi !
>>>>
>>>>
>>>>
>>>> There are these papers about
>>>>
>>>> These need a very critical reading to discuss
>>>>
>>>> This discussion with all about the matter and these papers is
>>>> very welcome! (at least for me!)
>>>>
>>>> Regards for all
>>>>
>>>> Luiz Ristow
>>>>
>>>>
>>>>
>>>> <image001.gif>
>>>>
>>>>
>>>>
>>>> De: <mailto:leish-l-bounces at lineu.icb.usp.br>
>>>> leish-l-bounces at lineu.icb.usp.br
>>>> [mailto:leish-l-bounces at lineu.icb.usp.br]
>>>> <mailto:%5bmailto:leish-l-bounces at lineu.icb.usp.br%5d> Em nome de
>>>> John David
>>>> Enviada em: segunda-feira, 26 de setembro de 2011 18:44
>>>> Para: Dr GR Rajasekariah
>>>> Cc: <mailto:leish-l at lineu.icb.usp.br>
>>>> leish-l at lineu.icb.usp.br;
>>>> Carlos Gouvea; hubert mazure; <mailto:smithyman at cellabs.com.au>
>>>> smithyman at cellabs.com.au
>>>> Assunto: Re: [Leish-l] testing vaccinated dogs for
>>>> immunopotentiation
>>>>
>>>>
>>>>
>>>> I think that for any vaccine developed to protect dogs
>>>> against
>>>> VL, but which is also meant to prevent transmission of VL to
>>>> humans,
>>>> the developers should show that after the vaccinated dog has been
>>>> challenged with Leishmania, it does not transmit Leishmania to sand
>>>> flies.
>>>>
>>>> John R David, M.D.
>>>>
>>>> Richard Pearson Strong Professor Emeritus
>>>>
>>>> Department of Immunology and Infectious Diseases
>>>>
>>>> Harvard School of Public Health
>>>>
>>>> Professor of Medicine, Harvard Medical School
>>>>
>>>> 300 W. 23rd Street, Apt. 13K
>>>>
>>>> New York, NY, 10011
>>>>
>>>> Tel: 212 414 8646
>>>>
>>>> Email: <mailto:jdavid at hsph.harvard.edu>
>>>> jdavid at hsph.harvard.edu
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> On Sep 19, 2011, at 12:04 AM, Dr GR Rajasekariah wrote:
>>>>
>>>>
>>>>
>>>> Hello EveryOne,
>>>> I am responding to the topic on European VL Dog vaccine.
>>>> It is a great challenge in devising a protective vaccine
>>>> against visceral leishmaniasis in dogs. This point equally applies
>>>> the same challenge for human situation.
>>>> Because Th-2 response is so dominant during VL infection,
>>>> modulating Th-2 into Th-1 response is a big challenge to
>>>> immunologists.
>>>>
>>>> Key points lies in the presentation of appropriate antigen in
>>>> appropriate dose to stimulate the Th-1 dependent protective immune
>>>> response.
>>>> I understand several vaccines are in the market and real
>>>> efficacy of these vaccines will come out once introduced to field
>>>> conditions.
>>>>
>>>> I just wanted to inform you that we have a suitable antibody
>>>> kit for testing the immunopotentiation in dogs following
>>>> vaccination
>>>> of dogs.
>>>> Our assay is based on the released promastigote antigens.
>>>> It is a highly sensitive assay.
>>>> Currently we supply reagents for determination of total IgG
>>>> antibodies in serum.
>>>> If any particular group is interested then we are able to
>>>> provide appropriate reagent for detection of specific IgG2 and
>>>> other
>>>> isotype specific antibody detection.
>>>> Because our antibody detection ELISA is based on the
>>>> exo-antigens such an ELISA would be of exceptional type for
>>>> measuring
>>>> antibody response in vaccinated animals.
>>>> Highly suitable for diagnosing dogs responded to vaccines.
>>>>
>>>> Recently I came to know that some of commercial kits were
>>>> found to be not useful for detecting seroconversion in dogs
>>>> vaccinated with FML vaccine (Leish-Immune) in Brazil.
>>>> Because we use released antigens in our kit, any such
>>>> problems
>>>> will overcome if they use Canine Leish IgG CELISA (Manufacturer
>>>> Cellabs Pty Ltd Brookvale NSW Australia email
>>>> <mailto:sales at cellabs.com.au> sales at cellabs.com.au).
>>>> If any one is interested to know more about our antibody
>>>> detection ELISA based on exo-antigens please contact us.
>>>>
>>>> This is for your kind information.
>>>>
>>>> Dr GR Rajasekariah
>>>> Sydney
>>>> Australia
>>>> <mailto:raj at cellabs.com.au> raj at cellabs.com.au
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> ----- Original Message ----- From: <
>>>> <mailto:leish-l-request at lineu.icb.usp.br>
>>>> leish-l-request at lineu.icb.usp.br>
>>>> To: < <mailto:leish-l at lineu.icb.usp.br>
>>>> leish-l at lineu.icb.usp.br>
>>>> Sent: Wednesday, August 10, 2011 5:18 PM
>>>> Subject: Leish-l Digest, Vol 44, Issue 3
>>>>
>>>> Send Leish-l mailing list submissions to
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>>>>
>>>>
>>>> When replying, please edit your Subject line so it is
>>>> more specific
>>>>
>>>> than "Re: Contents of Leish-l digest..."
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> Today's Topics:
>>>>
>>>>
>>>>
>>>> 1. European VL Dog Vaccine - CaniLeish?: (jeffrey
>>>> shaw)
>>>>
>>>> 2. Re: FW: Leishmaniasis Pathology Network (Moazzem
>>>> Hossain)
>>>>
>>>> 3. Re: FW: Leishmaniasis Pathology Network (Moazzem
>>>> Hossain)
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> ---------------------------------------------------------------------
>>>> -
>>>>
>>>>
>>>>
>>>> Message: 1
>>>>
>>>> Date: Tue, 9 Aug 2011 15:18:44 +0000
>>>>
>>>> From: jeffrey shaw < <mailto:jayusp at hotmail.com>
>>>> jayusp at hotmail.com>
>>>>
>>>> Subject: [Leish-l] European VL Dog Vaccine -
>>>> CaniLeish?:
>>>>
>>>> To: Leish-L < <mailto:leish-l at lineu.icb.usp.br>
>>>> leish-l at lineu.icb.usp.br>
>>>>
>>>> Message-ID: <
>>>> <mailto:COL101-W1CDD4171D44B715B795E9CB200 at phx.gbl>
>>>> COL101-W1CDD4171D44B715B795E9CB200 at phx.gbl>
>>>>
>>>> Content-Type: text/plain; charset="windows-1252"
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> CaniLeish?:
>>>>
>>>> The European Commission granted a marketing
>>>> authorisation valid throughout the European Union, for CaniLeish to
>>>> Virbac S.A. on 14/03/2011.
>>>>
>>>> This vaccine, CaniLeish?, will initially be launched
>>>> in Portugal at the end of the first half of 2011. This will be
>>>> followed rapidly by launches in other countries in the endemic
>>>> area:
>>>> Spain, France, Greece and Italy (not in chronological order). This
>>>> roll-out takes account of the geographical prevalence of the
>>>> disease
>>>> and the time required to build vaccine production up to full
>>>> capacity. The launch in Northern European countries from where
>>>> there
>>>> is a flow of summer visitors to the endemic area will be part of a
>>>> second phase.
>>>>
>>>> The basis of this vaccine are excreted proteins
>>>> plus
>>>> a saponin adjuvant purified from Quil-A. Its efficacy was
>>>> determined
>>>> in a
>>>> 2 year open field trial.
>>>>
>>>> The vaccine is given to dogs as three injections,
>>>> three weeks apart, under the skin. The first injection can be given
>>>> from six months of age, the second injection is given three weeks
>>>> later and the third three weeks from the second one. Afterward a
>>>> single ?booster?
>>>> should be given every year to maintain protection.
>>>>
>>>> -------------- next part --------------
>>>>
>>>> An HTML attachment was scrubbed...
>>>>
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>>>>
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>>>>
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>>>> 5e/
>>>> attachment-0001.htm>
>>>>
>>>>
>>>>
>>>> ------------------------------
>>>>
>>>>
>>>>
>>>> Message: 2
>>>>
>>>> Date: Wed, 10 Aug 2011 13:07:17 +0600
>>>>
>>>> From: Moazzem Hossain <
>>>> <mailto:directordcbd at gmail.com>
>>>> directordcbd at gmail.com>
>>>>
>>>> Subject: Re: [Leish-l] FW: Leishmaniasis Pathology
>>>> Network
>>>>
>>>> To: jeffrey shaw < <mailto:jayusp at hotmail.com>
>>>> jayusp at hotmail.com>, "Prof. Paul Kaye"
>>>>
>>>> < <mailto:paul.kaye at york.ac.uk> paul.kaye at york.ac.uk>
>>>>
>>>> Cc: "Prof. Dr. Moazzem Hossain" <
>>>> <mailto:profdrmoazzemhossain at gmail.com>
>>>> profdrmoazzemhossain at gmail.com>,
>>>>
>>>> Leish-L < <mailto:leish-l at lineu.icb.usp.br>
>>>> leish-l at lineu.icb.usp.br>
>>>>
>>>> Message-ID:
>>>>
>>>> <
>>>>
>>>> <mailto:CAE-TCmS=i=WaT8cAeOXUJmot=KPvMQSLKar6CTfuUBK9M9tsUw at mail.gmai
>>>> l.c
>>>> om>
>>>> CAE-TCmS=i=WaT8cAeOXUJmot=KPvMQSLKar6CTfuUBK9M9tsUw at mail.gmail.co
>>>> om> m>
>>>>
>>>> Content-Type: text/plain; charset=windows-1252
>>>>
>>>>
>>>>
>>>> 10 Aug 2011
>>>>
>>>>
>>>>
>>>> Dear Professor Paul Kaye,
>>>>
>>>>
>>>>
>>>> Thank you for your email. Please find attached our
>>>> supportive letter
>>>>
>>>> of interest for Leishmaniasis Pathology Network.
>>>>
>>>> Looking forward for your kind response.
>>>>
>>>>
>>>>
>>>> Best regards.
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> --
>>>>
>>>> *Prof. Dr. Moazzem Hossain *
>>>>
>>>> Ex - Director Disease Control
>>>>
>>>> Ministry of Health & Family Welfare
>>>>
>>>> Government of Bangladesh
>>>>
>>>> *Mailing address*:
>>>>
>>>> Founder Chairman and Project Director
>>>>
>>>> Institute of Allergy & Clinical Immunology of
>>>> Bangladesh
>>>> (IACIB)
>>>>
>>>> Room 4 - 5 (2nd Floor), Green Super Market, Green
>>>> Road
>>>>
>>>> Dhaka -1205, Bangladesh.
>>>>
>>>> Phone:880-2-8115646 (O )
>>>>
>>>> 880-1715038551(Mobile)
>>>>
>>>> Email: <mailto:directordcbd at gmail.com>
>>>> directordcbd at gmail.com
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> On 8/9/11, jeffrey shaw < <mailto:jayusp at hotmail.com>
>>>> jayusp at hotmail.com> wrote:
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> Date: Tue, 9 Aug 2011 11:58:52 +0100
>>>>
>>>> From: <mailto:paul.kaye at york.ac.uk>
>>>> paul.kaye at york.ac.uk
>>>>
>>>>
>>>>
>>>> Subject: Leishmaniasis Pathology Network
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> Dear all,
>>>>
>>>> Invitation to participate in a global
>>>> pathology
>>>>
>>>> network for
>>>>
>>>> research and training in leishmaniasis
>>>> (LeishPathNet)
>>>>
>>>> You may recall the Dormy House meeting in
>>>> 2008
>>>>
>>>> and some of
>>>>
>>>> the plans we put forward? Over
>>>>
>>>> the past
>>>>
>>>> couple years, I have also spoken more to
>>>> a
>>>> few of you about one
>>>>
>>>> idea that was
>>>>
>>>> formulated at Dormy, namely of setting
>>>> up
>>>> a digital pathology
>>>>
>>>> network. I have
>>>>
>>>> also had numerous discussions with the
>>>> major equipment
>>>>
>>>> manufacturers to see if
>>>>
>>>> any of them would be supportive of
>>>> helping
>>>> us to develop such an
>>>>
>>>> initiative. There have
>>>>
>>>> been two major
>>>>
>>>> develoments recently. First,
>>>>
>>>> Carl Zeiss
>>>>
>>>> is willing to work with us to set up an
>>>> integrated global digital
>>>>
>>>> pathology
>>>>
>>>> network (providing a significant
>>>> financial
>>>> and technical
>>>>
>>>> contribution) and
>>>>
>>>> second, the Wellcome Trust is willing to
>>>> review a pre-proposal to
>>>>
>>>> fund the
>>>>
>>>> initiative through their new Biomedical
>>>> Resources Grant scheme
>>>>
>>>> (
>>>>
>>>> <http://www.wellcome.ac.uk/Funding/Biomedical-science/Funding-schemes
>>>> /St rategic-awards-and-initiatives/wtdv031727.htm>
>>>>
>>>> http://www.wellcome.ac.uk/Funding/Biomedical-science/Funding-schemes/
>>>> Str
>>>> ategic-awards-and-initiatives/wtdv031727.htm)
>>>>
>>>> .
>>>>
>>>> I have attached an outline of the project
>>>> that
>>>>
>>>> I had sent to
>>>>
>>>> the Trust for their initial views, which
>>>> I
>>>> think is reasonably
>>>>
>>>> self-explanatory.
>>>>
>>>> They appeared very
>>>>
>>>> enthusiastic! The main
>>>>
>>>> question now is whether enough of
>>>>
>>>> you are still supportive? [ I will also
>>>> be
>>>> sending this email to
>>>>
>>>> others, but please feel free to
>>>> circulate
>>>> ]
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> I think the
>>>>
>>>> project will be
>>>>
>>>> challenging, but success could have a
>>>> real impact on the way we
>>>>
>>>> conduct
>>>>
>>>> business. It should serve not only as
>>>> a
>>>> vehicle to enhance
>>>>
>>>> research in
>>>>
>>>> leishmaniasis, but the model would be
>>>> equally applicable across
>>>>
>>>> a broad range
>>>>
>>>> of diseases and global challenges
>>>> (with
>>>> leishmaniasis setting
>>>>
>>>> the pace).
>>>>
>>>> If we wish to
>>>>
>>>> proceed, the requirements
>>>>
>>>> are that we submit a pre-proposal to
>>>> the
>>>> Trust by Oct 18th 2011.
>>>>
>>>> This pre-proposal is short (4 sections
>>>> of
>>>> 350 words) and
>>>>
>>>> requires
>>>>
>>>> letters of support from the community.
>>>>
>>>> If you are
>>>>
>>>> supportive of the idea that
>>>>
>>>> we try to take this forward (and there
>>>> is plenty of scope for
>>>>
>>>> later iteration
>>>>
>>>> of the detail), I would be grateful if
>>>> you could please provide
>>>>
>>>> me with a
>>>>
>>>> letter of support by September
>>>>
>>>> 12th
>>>>
>>>> 2011, indicating whether you would
>>>> like to be a network
>>>>
>>>> partner if the bid
>>>>
>>>> is successful. You could
>>>>
>>>> also be
>>>>
>>>> supportive but not wish to become
>>>> directly involved at this
>>>>
>>>> stage, and such
>>>>
>>>> letters are equally valuable. Your
>>>> letter might also stress the
>>>>
>>>> added value
>>>>
>>>> that the network could provide, its
>>>> importance for research and
>>>>
>>>> training and/or
>>>>
>>>> for progressing the translational
>>>> agenda.
>>>>
>>>> It would also be an opportunity to
>>>> indicate whether your
>>>>
>>>> group (or
>>>>
>>>> institute, if multiple groups) would
>>>> be
>>>> interested in bidding to
>>>>
>>>> be one of the
>>>>
>>>> initial ?designated laboratories?.
>>>>
>>>> If there is
>>>>
>>>> sufficient support to
>>>>
>>>> proceed and if subsequently the
>>>> pre-proposal is successful (we
>>>>
>>>> will know on 22nd
>>>>
>>>> Nov), then I will need a few
>>>> volunteers
>>>> to help finalise the
>>>>
>>>> full proposal,
>>>>
>>>> which will be due on Jan 26th 2012.
>>>>
>>>> A funding decision will be made on May
>>>> 26th
>>>>
>>>> 2012.
>>>>
>>>> Best wishes
>>>>
>>>> and of course I am happy to
>>>>
>>>> discuss any points further (though I
>>>> will be out of the UK from
>>>>
>>>> Aug 10 ?Sept
>>>>
>>>> 12)
>>>>
>>>> Paul
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> --
>>>>
>>>> Professor Paul Kaye, Ph.D., FRCPath.
>>>>
>>>> Deputy Dean (Research), Hull York Medical
>>>> School, and
>>>>
>>>> Director, Centre for Immunology and Infection
>>>>
>>>> Department of Biology and Hull York Medical
>>>> School
>>>>
>>>> University of York
>>>>
>>>> Wentworth Way
>>>>
>>>> York YO10 5YW
>>>>
>>>> United Kingdom
>>>>
>>>>
>>>>
>>>> Tel: +44 (0)1904 328840
>>>>
>>>> Fax: +44 (0)1904 328844
>>>>
>>>> Email: <mailto:paul.kaye at york.ac.uk>
>>>> paul.kaye at york.ac.uk < <mailto:paul.kaye at york.ac.uk>
>>>> mailto:paul.kaye at york.ac.uk>
>>>>
>>>>
>>>>
>>>> Centre Administrator and PA: Elizabeth
>>>> Greensted
>>>>
>>>> Tel: 01904 328845
>>>>
>>>> Email: <mailto:liz.greensted at york.ac.uk>
>>>> liz.greensted at york.ac.uk < <mailto:liz.greensted at york.ac.uk>
>>>> mailto:liz.greensted at york.ac.uk>
>>>>
>>>>
>>>>
>>>> Centre Email: <mailto:cii at york.ac.uk>
>>>> cii at york.ac.uk < <mailto:cii at york.ac.uk> mailto:cii at york.ac.uk>
>>>>
>>>>
>>>>
>>>> Centre website: <http://www.york.ac.uk/cii>
>>>> http://www.york.ac.uk/cii
>>>>
>>>>
>>>>
>>>> Times Higher Education University of the Year
>>>> 2010
>>>>
>>>>
>>>>
>>>> Email disclaimer:
>>>> <http://www.york.ac.uk/docs/disclaimer/email.htm>
>>>> http://www.york.ac.uk/docs/disclaimer/email.htm
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> ------------------------------
>>>>
>>>>
>>>>
>>>> Message: 3
>>>>
>>>> Date: Wed, 10 Aug 2011 13:06:47 +0600
>>>>
>>>> From: Moazzem Hossain <
>>>> <mailto:directordcbd at gmail.com>
>>>> directordcbd at gmail.com>
>>>>
>>>> Subject: Re: [Leish-l] FW: Leishmaniasis Pathology
>>>> Network
>>>>
>>>> To: jeffrey shaw < <mailto:jayusp at hotmail.com>
>>>> jayusp at hotmail.com>, "Prof. Paul Kaye"
>>>>
>>>> < <mailto:paul.kaye at york.ac.uk> paul.kaye at york.ac.uk>
>>>>
>>>> Cc: "Prof. Dr. Moazzem Hossain" <
>>>> <mailto:profdrmoazzemhossain at gmail.com>
>>>> profdrmoazzemhossain at gmail.com>,
>>>>
>>>> Leish-L < <mailto:leish-l at lineu.icb.usp.br>
>>>> leish-l at lineu.icb.usp.br>
>>>>
>>>> Message-ID:
>>>>
>>>> <
>>>>
>>>> <mailto:CAE-TCmQNUkZdNE5w+Z20bjLC-=vvV9BCP6OLOm9f6RV-BfpXvA at mail.gmai
>>>> l.c
>>>> om>
>>>> CAE-TCmQNUkZdNE5w+Z20bjLC-=vvV9BCP6OLOm9f6RV-BfpXvA at mail.gmail.co
>>>> om> CAE-TCmQNUkZdNE5w+m>
>>>>
>>>> Content-Type: text/plain; charset="windows-1252"
>>>>
>>>>
>>>>
>>>> 10 Aug 2011
>>>>
>>>>
>>>>
>>>> Dear Professor Paul Kaye,
>>>>
>>>>
>>>>
>>>> Thank you for your email. Please find attached our
>>>> supportive letter
>>>>
>>>> of interest for Leishmaniasis Pathology Network.
>>>>
>>>> Looking forward for your kind response.
>>>>
>>>>
>>>>
>>>> Best regards.
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> --
>>>>
>>>> *Prof. Dr. Moazzem Hossain *
>>>>
>>>> Ex - Director Disease Control
>>>>
>>>> Ministry of Health & Family Welfare
>>>>
>>>> Government of Bangladesh
>>>>
>>>> *Mailing address*:
>>>>
>>>> Founder Chairman and Project Director
>>>>
>>>> Institute of Allergy & Clinical Immunology of
>>>> Bangladesh
>>>> (IACIB)
>>>>
>>>> Room 4 - 5 (2nd Floor), Green Super Market, Green
>>>> Road
>>>>
>>>> Dhaka -1205, Bangladesh.
>>>>
>>>> Phone:880-2-8115646 (O )
>>>>
>>>> 880-1715038551(Mobile)
>>>>
>>>> Email: <mailto:directordcbd at gmail.com>
>>>> directordcbd at gmail.com
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> On 8/9/11, jeffrey shaw < <mailto:jayusp at hotmail.com>
>>>> jayusp at hotmail.com> wrote:
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> Date: Tue, 9 Aug 2011 11:58:52 +0100
>>>>
>>>> From: <mailto:paul.kaye at york.ac.uk>
>>>> paul.kaye at york.ac.uk
>>>>
>>>>
>>>>
>>>> Subject: Leishmaniasis Pathology Network
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> Dear all,
>>>>
>>>> Invitation to participate in a global
>>>> pathology
>>>>
>>>> network for
>>>>
>>>> research and training in leishmaniasis
>>>> (LeishPathNet)
>>>>
>>>> You may recall the Dormy House meeting in
>>>> 2008
>>>>
>>>> and some of
>>>>
>>>> the plans we put forward? Over
>>>>
>>>> the past
>>>>
>>>> couple years, I have also spoken more to
>>>> a
>>>> few of you about one
>>>>
>>>> idea that was
>>>>
>>>> formulated at Dormy, namely of setting
>>>> up
>>>> a digital pathology
>>>>
>>>> network. I have
>>>>
>>>> also had numerous discussions with the
>>>> major equipment
>>>>
>>>> manufacturers to see if
>>>>
>>>> any of them would be supportive of
>>>> helping
>>>> us to develop such an
>>>>
>>>> initiative. There have
>>>>
>>>> been two major
>>>>
>>>> develoments recently. First,
>>>>
>>>> Carl Zeiss
>>>>
>>>> is willing to work with us to set up an
>>>> integrated global digital
>>>>
>>>> pathology
>>>>
>>>> network (providing a significant
>>>> financial
>>>> and technical
>>>>
>>>> contribution) and
>>>>
>>>> second, the Wellcome Trust is willing to
>>>> review a pre-proposal to
>>>>
>>>> fund the
>>>>
>>>> initiative through their new Biomedical
>>>> Resources Grant scheme
>>>>
>>>> (
>>>>
>>>> <http://www.wellcome.ac.uk/Funding/Biomedical-science/Funding-schemes
>>>> /St rategic-awards-and-initiatives/wtdv031727.htm>
>>>>
>>>> http://www.wellcome.ac.uk/Funding/Biomedical-science/Funding-schemes/
>>>> Str
>>>> ategic-awards-and-initiatives/wtdv031727.htm)
>>>>
>>>> .
>>>>
>>>> I have attached an outline of the project
>>>> that
>>>>
>>>> I had sent to
>>>>
>>>> the Trust for their initial views, which
>>>> I
>>>> think is reasonably
>>>>
>>>> self-explanatory.
>>>>
>>>> They appeared very
>>>>
>>>> enthusiastic! The main
>>>>
>>>> question now is whether enough of
>>>>
>>>> you are still supportive? [ I will also
>>>> be
>>>> sending this email to
>>>>
>>>> others, but please feel free to
>>>> circulate
>>>> ]
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> I think the
>>>>
>>>> project will be
>>>>
>>>> challenging, but success could have a
>>>> real impact on the way we
>>>>
>>>> conduct
>>>>
>>>> business. It should serve not only as
>>>> a
>>>> vehicle to enhance
>>>>
>>>> research in
>>>>
>>>> leishmaniasis, but the model would be
>>>> equally applicable across
>>>>
>>>> a broad range
>>>>
>>>> of diseases and global challenges
>>>> (with
>>>> leishmaniasis setting
>>>>
>>>> the pace).
>>>>
>>>> If we wish to
>>>>
>>>> proceed, the requirements
>>>>
>>>> are that we submit a pre-proposal to
>>>> the
>>>> Trust by Oct 18th 2011.
>>>>
>>>> This pre-proposal is short (4 sections
>>>> of
>>>> 350 words) and
>>>>
>>>> requires
>>>>
>>>> letters of support from the community.
>>>>
>>>> If you are
>>>>
>>>> supportive of the idea that
>>>>
>>>> we try to take this forward (and there
>>>> is plenty of scope for
>>>>
>>>> later iteration
>>>>
>>>> of the detail), I would be grateful if
>>>> you could please provide
>>>>
>>>> me with a
>>>>
>>>> letter of support by September
>>>>
>>>> 12th
>>>>
>>>> 2011, indicating whether you would
>>>> like to be a network
>>>>
>>>> partner if the bid
>>>>
>>>> is successful. You could
>>>>
>>>> also be
>>>>
>>>> supportive but not wish to become
>>>> directly involved at this
>>>>
>>>> stage, and such
>>>>
>>>> letters are equally valuable. Your
>>>> letter might also stress the
>>>>
>>>> added value
>>>>
>>>> that the network could provide, its
>>>> importance for research and
>>>>
>>>> training and/or
>>>>
>>>> for progressing the translational
>>>> agenda.
>>>>
>>>> It would also be an opportunity to
>>>> indicate whether your
>>>>
>>>> group (or
>>>>
>>>> institute, if multiple groups) would
>>>> be
>>>> interested in bidding to
>>>>
>>>> be one of the
>>>>
>>>> initial ?designated laboratories?.
>>>>
>>>> If there is
>>>>
>>>> sufficient support to
>>>>
>>>> proceed and if subsequently the
>>>> pre-proposal is successful (we
>>>>
>>>> will know on 22nd
>>>>
>>>> Nov), then I will need a few
>>>> volunteers
>>>> to help finalise the
>>>>
>>>> full proposal,
>>>>
>>>> which will be due on Jan 26th 2012.
>>>>
>>>> A funding decision will be made on May
>>>> 26th
>>>>
>>>> 2012.
>>>>
>>>> Best wishes
>>>>
>>>> and of course I am happy to
>>>>
>>>> discuss any points further (though I
>>>> will be out of the UK from
>>>>
>>>> Aug 10 ?Sept
>>>>
>>>> 12)
>>>>
>>>> Paul
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> --
>>>>
>>>> Professor Paul Kaye, Ph.D., FRCPath.
>>>>
>>>> Deputy Dean (Research), Hull York Medical
>>>> School, and
>>>>
>>>> Director, Centre for Immunology and Infection
>>>>
>>>> Department of Biology and Hull York Medical
>>>> School
>>>>
>>>> University of York
>>>>
>>>> Wentworth Way
>>>>
>>>> York YO10 5YW
>>>>
>>>> United Kingdom
>>>>
>>>>
>>>>
>>>> Tel: +44 (0)1904 328840
>>>>
>>>> Fax: +44 (0)1904 328844
>>>>
>>>> Email: <mailto:paul.kaye at york.ac.uk>
>>>> paul.kaye at york.ac.uk < <mailto:paul.kaye at york.ac.uk>
>>>> mailto:paul.kaye at york.ac.uk>
>>>>
>>>>
>>>>
>>>> Centre Administrator and PA: Elizabeth
>>>> Greensted
>>>>
>>>> Tel: 01904 328845
>>>>
>>>> Email: <mailto:liz.greensted at york.ac.uk>
>>>> liz.greensted at york.ac.uk < <mailto:liz.greensted at york.ac.uk>
>>>> mailto:liz.greensted at york.ac.uk>
>>>>
>>>>
>>>>
>>>> Centre Email: <mailto:cii at york.ac.uk>
>>>> cii at york.ac.uk < <mailto:cii at york.ac.uk> mailto:cii at york.ac.uk>
>>>>
>>>>
>>>>
>>>> Centre website: <http://www.york.ac.uk/cii>
>>>> http://www.york.ac.uk/cii
>>>>
>>>>
>>>>
>>>> Times Higher Education University of the Year
>>>> 2010
>>>>
>>>>
>>>>
>>>> Email disclaimer:
>>>> <http://www.york.ac.uk/docs/disclaimer/email.htm>
>>>> http://www.york.ac.uk/docs/disclaimer/email.htm
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> -------------- next part --------------
>>>>
>>>> A non-text attachment was scrubbed...
>>>>
>>>> Name: Letter Leish UK.doc
>>>>
>>>> Type: application/msword
>>>>
>>>> Size: 46080 bytes
>>>>
>>>> Desc: not available
>>>>
>>>> URL: <
>>>>
>>>> <http://lineu.icb.usp.br/pipermail/leish-l/attachments/20110810/73f2a
>>>> e6a
>>>> /attachment.doc>
>>>>
>>>> http://lineu.icb.usp.br/pipermail/leish-l/attachments/20110810/73f2ae
>>>> 6a/
>>>> attachment.doc>
>>>>
>>>>
>>>>
>>>> ------------------------------
>>>>
>>>>
>>>>
>>>> _______________________________________________
>>>>
>>>> Leish-l mailing list
>>>>
>>>> <mailto:Leish-l at lineu.icb.usp.br>
>>>> Leish-l at lineu.icb.usp.br
>>>>
>>>>
>>>> <http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l>
>>>> http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> End of Leish-l Digest, Vol 44, Issue 3
>>>>
>>>> **************************************
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> =======
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>>>> (Email Guard: 7.0.0.26, Virus/Spyware Database: 6.18330)
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>>>> =======
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>>>>
>>>>
>>>>
>>>>
>>>>
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