[Leish-l] RES: testing vaccinated dogs for immunopotentiation

Patrick Bastien patrick.bastien at univ-montp1.fr
Sat Oct 15 05:12:38 BRT 2011


Dear KP,
That's it for article [3].
(don't ask me how I got this proof, I cant' remember).
Best wishes
P. Bastien

Professeur Patrick Bastien
Laboratoire de Parasitologie-Mycologie, Faculté de Médecine
UMR MIVEGEC (CNRS 5290 - IRD 224 - Université Montpellier 1)
Centre National de Référence des Leishmania
CHU de Montpellier
39 Avenue Charles Flahault
34295 Montpellier Cedex 5, France

"Chang, Kwang-Poo" <KwangPoo.Chang at rosalindfranklin.edu> a écrit :

> I also recall the description of sexual transmission in human   
> leishmaniasis in old literature, but this is rare.
>
>
> Going back to the issue of congenital transmission in human and   
> canine leishmaiasis, I listed 3 articles below from a pubmed search.
>
> [1] Pediatrics. 1999 Nov;104(5):e65.
> Congenital transmission of visceral leishmaniasis (Kala Azar) from   
> an asymptomatic mother to her child.
> Meinecke CK, Schottelius J, Oskam L, Fleischer B.
> SourceChildren's Hospital of Stuttgart (Olgahospital), Stuttgart, Germany.
>
>
>
> [2] J Parasitol. 2005 Aug;91(4):970-2.
> Transplacental transmission of a North American isolate of   
> Leishmania infantum in an experimentally infected beagle.
> Rosypal AC, Troy GC, Zajac AM, Frank G, Lindsay DS.
> SourceDepartment of Biomedical Sciences and Pathobiology,   
> Virginia-Maryland Regional College of Veterinary Medicine, Virginia   
> Tech, Blacksburg, Virginia 24061, USA
>
> [3] Vet Parasitol. 2009 Dec 3;166(1-2):159-62. Epub 2009 Aug 15.
> First report of vertical transmission of Leishmania (Leishmania)   
> infantum in a naturally infected bitch from Brazil.
> da Silva SM, Ribeiro VM, Ribeiro RR, Tafuri WL, Melo MN, Michalick MS.
> SourceDepartamento de Parasitologia, Instituto de Ciências   
> Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo   
> Horizonte, MG, Brazil.
>
> I hope Dr. Rosypal and the authors of article [3] could make the pdf  
>  reprints of their articles available, since they were published in   
> journals, which are not readily available.
>
>
>
> KP
>
> -----Original Message-----
> From: leish-l-bounces at lineu.icb.usp.br   
> [mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Christopher   
> Peacock
> Sent: Sunday, October 09, 2011 10:33 PM
> To: leish-l at lineu.icb.usp.br
> Subject: Re: [Leish-l] RES: testing vaccinated dogs for immunopotentiation
>
> Hi,
> There is also this rather bizarre story of a Gulf War veteran who   
> returned with leishmaniasis, this link is a Veterans association   
> website and suggest both sexual transmission and vertical   
> transmission. Not sure how reliable this information is but it does   
> seem to be contested in court. Would be interesting to know more   
> details on this case and whether it has any evidence to support the   
> cases, as far as I am aware there has only been one suggested case   
> of sexually transmitted Leishmania in humans documented many years   
> ago.
>
> http://www.vawatchdog.org/07/nf07/nfJUN07/nf062907-3.htm
>
> http://www.leishmaniasis.us/Leish.html
>
> Cheers
>
> Chris
>
> Associate Professor Christopher Peacock
>   Discipline of Microbiology & Immunology M502
>   School of Biomedical, Biomolecular & Chemical Sciences
>   The University of Western Australia
>   Nedlands WA 6009
>
>   ph  00 61(0)8 9287 6172
>   fax 00 61(0)8 9346 2912
>
> -----Original Message-----
> From: leish-l-bounces at lineu.icb.usp.br   
> [mailto:leish-l-bounces at lineu.icb.usp.br] On Behalf Of Patrick Bastien
> Sent: Saturday, 8 October 2011 1:31 AM
> To: leish-l at lineu.icb.usp.br
> Subject: Re: [Leish-l] RES: testing vaccinated dogs for immunopotentiation
>
> There were several earlier reports of this vertical transmission, even
> in the US: among others,
> Rosypal AC, J.Parasitol. 2005, 970-972 and 113-115
> Magno da Silva, Vet Parasitol 2009
> Pangrazio, Vet Parasitol 2009
>
> Best regards
> P. Bastien
>
> Professeur Patrick Bastien
> Laboratoire de Parasitologie-Mycologie, Faculté de Médecine
> UMR MIVEGEC (CNRS 5290 - IRD 224 - Université Montpellier 1)
> Centre National de Référence des Leishmania
> CHU de Montpellier
> 39 Avenue Charles Flahault
> 34295 Montpellier Cedex 5, France
>
> "Chang, Kwang-Poo" <KwangPoo.Chang at rosalindfranklin.edu> a écrit :
>
>> What Jenni said indicates that transplacental transmission of canine
>> leishmaniasis has some implication in considering dog vaccination.
>>
>>
>>
>> Of further interest is the question of whether this transplacental
>> transmission could also occur in other reservoir animals or even in
>> human leishmaniasis ? I recall the description of such transmission in
>> human cases in some very early literature, but that has been always
>> considered as unlikely or extremely rare, more as a hypothesis than
>> reality. This issue may have been addressed in more recent
>> epidemiological studies of VL familial clustering in well-established
>> endemic sites ? Congenital transmission might escape our attention,
>> should the outcome be largely asymptomatic ?
>>
>>
>>
>> KP
>>
>>
>>
>> ________________________________
>>
>> From: Jennie Blackwell [mailto:jmb37 at cam.ac.uk]
>> Sent: Wednesday, October 05, 2011 6:46 PM
>> To: Chang, Kwang-Poo
>> Cc: Petersen, Christine A [V PTH]; TECSA - Luiz Ristow; John David;
>> leish-l at lineu.icb.usp.br
>> Subject: Re: [Leish-l] RES: testing vaccinated dogs for
>> immunopotentiation
>>
>>
>>
>> I doubt it. Treatment might but if the mum was already infected and
>> passed the parasite to the foetus I don't see how a vaccine would work
>> to clear the parasite from the foetus!
>>
>>
>>
>> Slightly different question as to whether vaccinating mums will give
>> them sufficient protection to not pass the parasite to the pup in utero
>> should they get infected themselves after vaccination.
>>
>>
>>
>> Cheers all, Jennie
>>
>> Jenefer M. Blackwell
>>
>> TICHR, CCHR, UWA
>>
>> Phone: +61 8 94897910
>>
>> From my iPhone
>>
>>
>> On 29 Sep 2011, at 00:36, "Chang, Kwang-Poo"
>> <KwangPoo.Chang at rosalindfranklin.edu> wrote:
>>
>>       Of interest is the question of whether vaccination would clear
>> the infection of the pub, which has congenitally inherited L infantum ?
>>
>>
>>
>>       KP
>>
>>
>>
>>
>> ________________________________
>>
>>
>>       From: Petersen, Christine A [V PTH] [mailto:kalicat at iastate.edu]
>>
>>       Sent: Wednesday, September 28, 2011 11:23 AM
>>       To: Chang, Kwang-Poo; TECSA - Luiz Ristow; John David
>>       Cc: leish-l at lineu.icb.usp.br; Petersen, Christine A [V PTH]
>>       Subject: RE: [Leish-l] RES: testing vaccinated dogs for
>> immunopotentiation
>>
>>
>>
>>       The reference for this article is:
>> <http://www.ncbi.nlm.nih.gov/pubmed/21532741>
>> http://www.ncbi.nlm.nih.gov/pubmed/21532741
>>
>>       As it was published in a PLoS journal its free access to all.
>>
>>       Based on our studies and recent ones from Brazil, I do believe
>> that to remove Leish from the canine reservoir, transmission from mom to
>> pup will need to be addressed.
>>
>>       Christy Petersen
>>
>>
>>
>>       From: Chang, Kwang-Poo
>> [mailto:KwangPoo.Chang at rosalindfranklin.edu]
>>       Sent: Wednesday, September 28, 2011 10:20 AM
>>       To: TECSA - Luiz Ristow; John David
>>       Cc: leish-l at lineu.icb.usp.br; Petersen, Christine A [V PTH]
>>       Subject: RE: [Leish-l] RES: testing vaccinated dogs for
>> immunopotentiation
>>
>>
>>
>>       Christine Petersen published an article about transplacental
>> transmission of L infantum in the USA canine leishmaniasis. I just
>> wonder about the implication of this finding in considering vaccination
>> against the disease transmitted this way ?
>>
>>
>>
>>       KP
>>
>>
>>
>>
>> ________________________________
>>
>>
>>       From: <mailto:leish-l-bounces at lineu.icb.usp.br>
>> leish-l-bounces at lineu.icb.usp.br
>> [mailto:leish-l-bounces at lineu.icb.usp.br]
>> <mailto:%5bmailto:leish-l-bounces at lineu.icb.usp.br%5d>  On Behalf Of
>> TECSA - Luiz Ristow
>>       Sent: Wednesday, September 28, 2011 9:08 AM
>>       To: 'John David'
>>       Cc: <mailto:leish-l at lineu.icb.usp.br> leish-l at lineu.icb.usp.br
>>       Subject: [Leish-l] RES: testing vaccinated dogs for
>> immunopotentiation
>>
>>
>>
>>       Hi !
>>
>>
>>
>>       There are these papers about
>>
>>       These need a very critical reading to discuss
>>
>>       This discussion with all about the matter and these papers is
>> very welcome! (at least for me!)
>>
>>       Regards for all
>>
>>       Luiz Ristow
>>
>>
>>
>>       <image001.gif>
>>
>>
>>
>>       De: <mailto:leish-l-bounces at lineu.icb.usp.br>
>> leish-l-bounces at lineu.icb.usp.br
>> [mailto:leish-l-bounces at lineu.icb.usp.br]
>> <mailto:%5bmailto:leish-l-bounces at lineu.icb.usp.br%5d>  Em nome de John
>> David
>>       Enviada em: segunda-feira, 26 de setembro de 2011 18:44
>>       Para: Dr GR Rajasekariah
>>       Cc: <mailto:leish-l at lineu.icb.usp.br> leish-l at lineu.icb.usp.br;
>> Carlos Gouvea; hubert mazure; <mailto:smithyman at cellabs.com.au>
>> smithyman at cellabs.com.au
>>       Assunto: Re: [Leish-l] testing vaccinated dogs for
>> immunopotentiation
>>
>>
>>
>>       I think that for any vaccine developed to protect dogs against
>> VL, but which is also meant to prevent transmission of VL to humans, the
>> developers should show that after the vaccinated dog has been challenged
>> with Leishmania, it does not transmit Leishmania to sand flies.
>>
>>       John R David, M.D.
>>
>>       Richard Pearson Strong Professor Emeritus
>>
>>       Department of Immunology and Infectious Diseases
>>
>>       Harvard School of Public Health
>>
>>       Professor of Medicine, Harvard Medical School
>>
>>       300 W. 23rd Street, Apt. 13K
>>
>>       New York, NY, 10011
>>
>>       Tel: 212 414 8646
>>
>>       Email: <mailto:jdavid at hsph.harvard.edu> jdavid at hsph.harvard.edu
>>
>>
>>
>>
>>
>>       On Sep 19, 2011, at 12:04 AM, Dr GR Rajasekariah wrote:
>>
>>
>>
>>       Hello EveryOne,
>>       I am responding to the topic on European VL Dog vaccine.
>>       It is a great challenge in devising a protective vaccine
>> against visceral leishmaniasis in dogs. This point equally applies the
>> same challenge for human situation.
>>       Because Th-2 response is so dominant during VL infection,
>> modulating Th-2 into Th-1 response is a big challenge to immunologists.
>>
>>       Key points lies in the presentation of appropriate antigen in
>> appropriate dose to stimulate the  Th-1 dependent protective immune
>> response.
>>       I understand several vaccines are in the market and real
>> efficacy of these vaccines will come out once introduced to field
>> conditions.
>>
>>       I just wanted to inform you that we have a suitable antibody kit
>> for testing the immunopotentiation in dogs following vaccination of
>> dogs.
>>       Our assay is based on the released promastigote antigens.
>>       It is a highly sensitive assay.
>>       Currently we supply reagents for  determination of total IgG
>> antibodies in serum.
>>       If any particular group is interested then we are able to
>> provide appropriate reagent for detection of specific IgG2 and other
>> isotype specific antibody detection.
>>       Because our antibody detection ELISA is based on the
>> exo-antigens such an ELISA would be of exceptional type for measuring
>> antibody response in vaccinated animals.
>>       Highly suitable for diagnosing dogs responded to vaccines.
>>
>>       Recently I came to know that some of  commercial kits were found
>> to be not useful for detecting seroconversion in dogs vaccinated with
>> FML vaccine (Leish-Immune) in Brazil.
>>       Because we use released antigens in our kit, any such problems
>> will overcome if they use Canine Leish IgG CELISA (Manufacturer Cellabs
>> Pty Ltd Brookvale NSW Australia email <mailto:sales at cellabs.com.au>
>> sales at cellabs.com.au).
>>       If any one is interested to know more about our antibody
>> detection ELISA based on exo-antigens please contact us.
>>
>>       This is for your kind information.
>>
>>       Dr GR Rajasekariah
>>       Sydney
>>       Australia
>>       <mailto:raj at cellabs.com.au> raj at cellabs.com.au
>>
>>
>>
>>
>>
>>
>>       ----- Original Message ----- From: <
>> <mailto:leish-l-request at lineu.icb.usp.br>
>> leish-l-request at lineu.icb.usp.br>
>>       To: < <mailto:leish-l at lineu.icb.usp.br>
>> leish-l at lineu.icb.usp.br>
>>       Sent: Wednesday, August 10, 2011 5:18 PM
>>       Subject: Leish-l Digest, Vol 44, Issue 3
>>
>>       Send Leish-l mailing list submissions to
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>>
>>               When replying, please edit your Subject line so it is
>> more specific
>>
>>               than "Re: Contents of Leish-l digest..."
>>
>>
>>
>>
>>
>>               Today's Topics:
>>
>>
>>
>>                1. European VL Dog Vaccine - CaniLeish?: (jeffrey shaw)
>>
>>                2. Re: FW: Leishmaniasis Pathology Network (Moazzem
>> Hossain)
>>
>>                3. Re: FW: Leishmaniasis Pathology Network (Moazzem
>> Hossain)
>>
>>
>>
>>
>>
>>
>> ----------------------------------------------------------------------
>>
>>
>>
>>               Message: 1
>>
>>               Date: Tue, 9 Aug 2011 15:18:44 +0000
>>
>>               From: jeffrey shaw < <mailto:jayusp at hotmail.com>
>> jayusp at hotmail.com>
>>
>>               Subject: [Leish-l] European VL Dog Vaccine - CaniLeish?:
>>
>>               To: Leish-L < <mailto:leish-l at lineu.icb.usp.br>
>> leish-l at lineu.icb.usp.br>
>>
>>               Message-ID: <
>> <mailto:COL101-W1CDD4171D44B715B795E9CB200 at phx.gbl>
>> COL101-W1CDD4171D44B715B795E9CB200 at phx.gbl>
>>
>>               Content-Type: text/plain; charset="windows-1252"
>>
>>
>>
>>
>>
>>               CaniLeish?:
>>
>>                 The European Commission granted a marketing
>> authorisation valid throughout the European Union, for CaniLeish to
>> Virbac S.A. on 14/03/2011.
>>
>>                This vaccine, CaniLeish?, will initially be launched in
>> Portugal at the end of the first half of 2011. This will be followed
>> rapidly by launches in other countries in the endemic area: Spain,
>> France, Greece and Italy (not in chronological order). This roll-out
>> takes account of the geographical prevalence of the disease and the time
>> required to build vaccine production up to full capacity. The launch in
>> Northern European countries from where there is a flow of summer
>> visitors to the endemic area will be part of a second phase.
>>
>>                 The basis of this vaccine are excreted proteins plus a
>> saponin adjuvant purified from Quil-A. Its efficacy was determined in a
>> 2 year open field trial.
>>
>>                 The vaccine is given to dogs as three injections,
>> three weeks apart, under the skin. The first injection can be given from
>> six months of age, the second injection is given three weeks later and
>> the third three weeks from the second one. Afterward a single ?booster?
>> should be given every year to maintain protection.
>>
>>               -------------- next part --------------
>>
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>>
>>
>>               ------------------------------
>>
>>
>>
>>               Message: 2
>>
>>               Date: Wed, 10 Aug 2011 13:07:17 +0600
>>
>>               From: Moazzem Hossain < <mailto:directordcbd at gmail.com>
>> directordcbd at gmail.com>
>>
>>               Subject: Re: [Leish-l] FW: Leishmaniasis Pathology
>> Network
>>
>>               To: jeffrey shaw < <mailto:jayusp at hotmail.com>
>> jayusp at hotmail.com>, "Prof. Paul Kaye"
>>
>>               < <mailto:paul.kaye at york.ac.uk> paul.kaye at york.ac.uk>
>>
>>               Cc: "Prof. Dr. Moazzem Hossain" <
>> <mailto:profdrmoazzemhossain at gmail.com> profdrmoazzemhossain at gmail.com>,
>>
>>               Leish-L < <mailto:leish-l at lineu.icb.usp.br>
>> leish-l at lineu.icb.usp.br>
>>
>>               Message-ID:
>>
>>               <
>> <mailto:CAE-TCmS=i=WaT8cAeOXUJmot=KPvMQSLKar6CTfuUBK9M9tsUw at mail.gmail.c
>> om> CAE-TCmS=i=WaT8cAeOXUJmot=KPvMQSLKar6CTfuUBK9M9tsUw at mail.gmail.com>
>>
>>               Content-Type: text/plain; charset=windows-1252
>>
>>
>>
>>               10 Aug 2011
>>
>>
>>
>>               Dear Professor Paul Kaye,
>>
>>
>>
>>               Thank you for your email. Please find attached our
>> supportive letter
>>
>>               of interest for Leishmaniasis Pathology Network.
>>
>>               Looking forward for your kind response.
>>
>>
>>
>>               Best regards.
>>
>>
>>
>>
>>
>>               --
>>
>>               *Prof. Dr. Moazzem Hossain *
>>
>>               Ex - Director Disease Control
>>
>>               Ministry of Health & Family Welfare
>>
>>               Government of  Bangladesh
>>
>>               *Mailing address*:
>>
>>               Founder Chairman and Project Director
>>
>>               Institute of Allergy & Clinical Immunology of Bangladesh
>> (IACIB)
>>
>>               Room 4 - 5 (2nd Floor), Green Super Market, Green Road
>>
>>               Dhaka -1205, Bangladesh.
>>
>>               Phone:880-2-8115646 (O )
>>
>>                       880-1715038551(Mobile)
>>
>>               Email: <mailto:directordcbd at gmail.com>
>> directordcbd at gmail.com
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>               On 8/9/11, jeffrey shaw < <mailto:jayusp at hotmail.com>
>> jayusp at hotmail.com> wrote:
>>
>>
>>
>>
>>
>>
>>
>>                       Date: Tue, 9 Aug 2011 11:58:52 +0100
>>
>>                       From: <mailto:paul.kaye at york.ac.uk>
>> paul.kaye at york.ac.uk
>>
>>
>>
>>                       Subject: Leishmaniasis Pathology Network
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>                          Dear all,
>>
>>                          Invitation to participate in a global
>> pathology
>>
>>                            network for
>>
>>                            research and training in leishmaniasis
>> (LeishPathNet)
>>
>>                          You may recall the Dormy House meeting in
>> 2008
>>
>>                            and some of
>>
>>                            the plans we put forward?  Over
>>
>>                            the past
>>
>>                            couple years, I have also spoken more to a
>> few of you about one
>>
>>                            idea that was
>>
>>                            formulated at Dormy, namely of setting up a
>> digital pathology
>>
>>                            network. I have
>>
>>                            also had numerous discussions with the
>> major equipment
>>
>>                            manufacturers to see if
>>
>>                            any of them would be supportive of helping
>> us to develop such an
>>
>>                            initiative.  There have
>>
>>                            been two major
>>
>>                            develoments recently.  First,
>>
>>                            Carl Zeiss
>>
>>                            is willing to work with us to set up an
>> integrated global digital
>>
>>                            pathology
>>
>>                            network (providing a significant financial
>> and technical
>>
>>                            contribution) and
>>
>>                            second, the Wellcome Trust is willing to
>> review a pre-proposal to
>>
>>                            fund the
>>
>>                            initiative through their new Biomedical
>> Resources Grant scheme
>>
>>                       (
>> <http://www.wellcome.ac.uk/Funding/Biomedical-science/Funding-schemes/St
>> rategic-awards-and-initiatives/wtdv031727.htm>
>> http://www.wellcome.ac.uk/Funding/Biomedical-science/Funding-schemes/Str
>> ategic-awards-and-initiatives/wtdv031727.htm)
>>
>>                            .
>>
>>                          I have attached an outline of the project
>> that
>>
>>                            I had sent to
>>
>>                            the Trust for their initial views, which I
>> think is reasonably
>>
>>                            self-explanatory.
>>
>>                             They appeared very
>>
>>                            enthusiastic!  The main
>>
>>                            question now is whether enough of
>>
>>                            you are still supportive? [ I will also be
>> sending this email to
>>
>>                            others, but please feel free to circulate ]
>>
>>
>>
>>
>>
>>                          I think the
>>
>>                              project will be
>>
>>                              challenging, but success could have a
>> real impact on the way we
>>
>>                              conduct
>>
>>                              business.  It should serve not only as a
>> vehicle to enhance
>>
>>                              research in
>>
>>                              leishmaniasis, but the model would be
>> equally applicable across
>>
>>                              a broad range
>>
>>                              of diseases and global challenges (with
>> leishmaniasis setting
>>
>>                              the pace).
>>
>>                          If we wish to
>>
>>                              proceed, the requirements
>>
>>                              are that we submit a pre-proposal to the
>> Trust by Oct 18th 2011.
>>
>>                              This pre-proposal is short (4 sections of
>> 350 words) and
>>
>>                              requires
>>
>>                              letters of support from the community.
>>
>>                          If you are
>>
>>                              supportive of the idea that
>>
>>                              we try to take this forward (and there is
>> plenty of scope for
>>
>>                              later iteration
>>
>>                              of the detail), I would be grateful if
>> you could please provide
>>
>>                              me with a
>>
>>                              letter of support by September
>>
>>                                12th
>>
>>                                2011, indicating whether you would like
>> to be a network
>>
>>                              partner if the bid
>>
>>                              is successful.  You could
>>
>>                              also be
>>
>>                              supportive but not wish to become
>> directly involved at this
>>
>>                              stage, and such
>>
>>                              letters are equally valuable. Your letter
>> might also stress the
>>
>>                              added value
>>
>>                              that the network could provide, its
>> importance for research and
>>
>>                              training and/or
>>
>>                              for progressing the translational agenda.
>>
>>                              It would also be an opportunity to
>> indicate whether your
>>
>>                              group (or
>>
>>                              institute, if multiple groups) would be
>> interested in bidding to
>>
>>                              be one of the
>>
>>                              initial ?designated laboratories?.
>>
>>                          If there is
>>
>>                              sufficient support to
>>
>>                              proceed and if subsequently the
>> pre-proposal is successful (we
>>
>>                              will know on 22nd
>>
>>                              Nov), then I will need a few volunteers
>> to help finalise the
>>
>>                              full proposal,
>>
>>                              which will be due on Jan 26th 2012.
>>
>>                              A funding decision will be made on May
>> 26th
>>
>>                              2012.
>>
>>                          Best wishes
>>
>>                              and of course I am happy to
>>
>>                              discuss any points further (though I will
>> be out of the UK from
>>
>>                              Aug 10 ?Sept
>>
>>                              12)
>>
>>                          Paul
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>                          --
>>
>>                       Professor Paul Kaye, Ph.D., FRCPath.
>>
>>                       Deputy Dean (Research), Hull York Medical
>> School, and
>>
>>                       Director, Centre for Immunology and Infection
>>
>>                       Department of Biology and Hull York Medical
>> School
>>
>>                       University of York
>>
>>                       Wentworth Way
>>
>>                       York YO10 5YW
>>
>>                       United Kingdom
>>
>>
>>
>>                       Tel:  +44 (0)1904 328840
>>
>>                       Fax:  +44 (0)1904 328844
>>
>>                       Email: <mailto:paul.kaye at york.ac.uk>
>> paul.kaye at york.ac.uk < <mailto:paul.kaye at york.ac.uk>
>> mailto:paul.kaye at york.ac.uk>
>>
>>
>>
>>                       Centre Administrator and PA: Elizabeth Greensted
>>
>>                       Tel:  01904 328845
>>
>>                       Email: <mailto:liz.greensted at york.ac.uk>
>> liz.greensted at york.ac.uk < <mailto:liz.greensted at york.ac.uk>
>> mailto:liz.greensted at york.ac.uk>
>>
>>
>>
>>                       Centre Email: <mailto:cii at york.ac.uk>
>> cii at york.ac.uk < <mailto:cii at york.ac.uk> mailto:cii at york.ac.uk>
>>
>>
>>
>>                       Centre website: <http://www.york.ac.uk/cii>
>> http://www.york.ac.uk/cii
>>
>>
>>
>>                       Times Higher Education University of the Year
>> 2010
>>
>>
>>
>>                       Email disclaimer:
>> <http://www.york.ac.uk/docs/disclaimer/email.htm>
>> http://www.york.ac.uk/docs/disclaimer/email.htm
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>               ------------------------------
>>
>>
>>
>>               Message: 3
>>
>>               Date: Wed, 10 Aug 2011 13:06:47 +0600
>>
>>               From: Moazzem Hossain < <mailto:directordcbd at gmail.com>
>> directordcbd at gmail.com>
>>
>>               Subject: Re: [Leish-l] FW: Leishmaniasis Pathology
>> Network
>>
>>               To: jeffrey shaw < <mailto:jayusp at hotmail.com>
>> jayusp at hotmail.com>, "Prof. Paul Kaye"
>>
>>               < <mailto:paul.kaye at york.ac.uk> paul.kaye at york.ac.uk>
>>
>>               Cc: "Prof. Dr. Moazzem Hossain" <
>> <mailto:profdrmoazzemhossain at gmail.com> profdrmoazzemhossain at gmail.com>,
>>
>>               Leish-L < <mailto:leish-l at lineu.icb.usp.br>
>> leish-l at lineu.icb.usp.br>
>>
>>               Message-ID:
>>
>>               <
>> <mailto:CAE-TCmQNUkZdNE5w+Z20bjLC-=vvV9BCP6OLOm9f6RV-BfpXvA at mail.gmail.c
>> om> CAE-TCmQNUkZdNE5w+Z20bjLC-=vvV9BCP6OLOm9f6RV-BfpXvA at mail.gmail.com>
>>
>>               Content-Type: text/plain; charset="windows-1252"
>>
>>
>>
>>               10 Aug 2011
>>
>>
>>
>>               Dear Professor Paul Kaye,
>>
>>
>>
>>               Thank you for your email. Please find attached our
>> supportive letter
>>
>>               of interest for Leishmaniasis Pathology Network.
>>
>>               Looking forward for your kind response.
>>
>>
>>
>>               Best regards.
>>
>>
>>
>>
>>
>>               --
>>
>>               *Prof. Dr. Moazzem Hossain *
>>
>>               Ex - Director Disease Control
>>
>>               Ministry of Health & Family Welfare
>>
>>               Government of  Bangladesh
>>
>>               *Mailing address*:
>>
>>               Founder Chairman and Project Director
>>
>>               Institute of Allergy & Clinical Immunology of Bangladesh
>> (IACIB)
>>
>>               Room 4 - 5 (2nd Floor), Green Super Market, Green Road
>>
>>               Dhaka -1205, Bangladesh.
>>
>>               Phone:880-2-8115646 (O )
>>
>>                       880-1715038551(Mobile)
>>
>>               Email: <mailto:directordcbd at gmail.com>
>> directordcbd at gmail.com
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>               On 8/9/11, jeffrey shaw < <mailto:jayusp at hotmail.com>
>> jayusp at hotmail.com> wrote:
>>
>>
>>
>>
>>
>>
>>
>>                       Date: Tue, 9 Aug 2011 11:58:52 +0100
>>
>>                       From: <mailto:paul.kaye at york.ac.uk>
>> paul.kaye at york.ac.uk
>>
>>
>>
>>                       Subject: Leishmaniasis Pathology Network
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>                          Dear all,
>>
>>                          Invitation to participate in a global
>> pathology
>>
>>                            network for
>>
>>                            research and training in leishmaniasis
>> (LeishPathNet)
>>
>>                          You may recall the Dormy House meeting in
>> 2008
>>
>>                            and some of
>>
>>                            the plans we put forward?  Over
>>
>>                            the past
>>
>>                            couple years, I have also spoken more to a
>> few of you about one
>>
>>                            idea that was
>>
>>                            formulated at Dormy, namely of setting up a
>> digital pathology
>>
>>                            network. I have
>>
>>                            also had numerous discussions with the
>> major equipment
>>
>>                            manufacturers to see if
>>
>>                            any of them would be supportive of helping
>> us to develop such an
>>
>>                            initiative.  There have
>>
>>                            been two major
>>
>>                            develoments recently.  First,
>>
>>                            Carl Zeiss
>>
>>                            is willing to work with us to set up an
>> integrated global digital
>>
>>                            pathology
>>
>>                            network (providing a significant financial
>> and technical
>>
>>                            contribution) and
>>
>>                            second, the Wellcome Trust is willing to
>> review a pre-proposal to
>>
>>                            fund the
>>
>>                            initiative through their new Biomedical
>> Resources Grant scheme
>>
>>                       (
>> <http://www.wellcome.ac.uk/Funding/Biomedical-science/Funding-schemes/St
>> rategic-awards-and-initiatives/wtdv031727.htm>
>> http://www.wellcome.ac.uk/Funding/Biomedical-science/Funding-schemes/Str
>> ategic-awards-and-initiatives/wtdv031727.htm)
>>
>>                            .
>>
>>                          I have attached an outline of the project
>> that
>>
>>                            I had sent to
>>
>>                            the Trust for their initial views, which I
>> think is reasonably
>>
>>                            self-explanatory.
>>
>>                             They appeared very
>>
>>                            enthusiastic!  The main
>>
>>                            question now is whether enough of
>>
>>                            you are still supportive? [ I will also be
>> sending this email to
>>
>>                            others, but please feel free to circulate ]
>>
>>
>>
>>
>>
>>                          I think the
>>
>>                              project will be
>>
>>                              challenging, but success could have a
>> real impact on the way we
>>
>>                              conduct
>>
>>                              business.  It should serve not only as a
>> vehicle to enhance
>>
>>                              research in
>>
>>                              leishmaniasis, but the model would be
>> equally applicable across
>>
>>                              a broad range
>>
>>                              of diseases and global challenges (with
>> leishmaniasis setting
>>
>>                              the pace).
>>
>>                          If we wish to
>>
>>                              proceed, the requirements
>>
>>                              are that we submit a pre-proposal to the
>> Trust by Oct 18th 2011.
>>
>>                              This pre-proposal is short (4 sections of
>> 350 words) and
>>
>>                              requires
>>
>>                              letters of support from the community.
>>
>>                          If you are
>>
>>                              supportive of the idea that
>>
>>                              we try to take this forward (and there is
>> plenty of scope for
>>
>>                              later iteration
>>
>>                              of the detail), I would be grateful if
>> you could please provide
>>
>>                              me with a
>>
>>                              letter of support by September
>>
>>                                12th
>>
>>                                2011, indicating whether you would like
>> to be a network
>>
>>                              partner if the bid
>>
>>                              is successful.  You could
>>
>>                              also be
>>
>>                              supportive but not wish to become
>> directly involved at this
>>
>>                              stage, and such
>>
>>                              letters are equally valuable. Your letter
>> might also stress the
>>
>>                              added value
>>
>>                              that the network could provide, its
>> importance for research and
>>
>>                              training and/or
>>
>>                              for progressing the translational agenda.
>>
>>                              It would also be an opportunity to
>> indicate whether your
>>
>>                              group (or
>>
>>                              institute, if multiple groups) would be
>> interested in bidding to
>>
>>                              be one of the
>>
>>                              initial ?designated laboratories?.
>>
>>                          If there is
>>
>>                              sufficient support to
>>
>>                              proceed and if subsequently the
>> pre-proposal is successful (we
>>
>>                              will know on 22nd
>>
>>                              Nov), then I will need a few volunteers
>> to help finalise the
>>
>>                              full proposal,
>>
>>                              which will be due on Jan 26th 2012.
>>
>>                              A funding decision will be made on May
>> 26th
>>
>>                              2012.
>>
>>                          Best wishes
>>
>>                              and of course I am happy to
>>
>>                              discuss any points further (though I will
>> be out of the UK from
>>
>>                              Aug 10 ?Sept
>>
>>                              12)
>>
>>                          Paul
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>
>>                          --
>>
>>                       Professor Paul Kaye, Ph.D., FRCPath.
>>
>>                       Deputy Dean (Research), Hull York Medical
>> School, and
>>
>>                       Director, Centre for Immunology and Infection
>>
>>                       Department of Biology and Hull York Medical
>> School
>>
>>                       University of York
>>
>>                       Wentworth Way
>>
>>                       York YO10 5YW
>>
>>                       United Kingdom
>>
>>
>>
>>                       Tel:  +44 (0)1904 328840
>>
>>                       Fax:  +44 (0)1904 328844
>>
>>                       Email: <mailto:paul.kaye at york.ac.uk>
>> paul.kaye at york.ac.uk < <mailto:paul.kaye at york.ac.uk>
>> mailto:paul.kaye at york.ac.uk>
>>
>>
>>
>>                       Centre Administrator and PA: Elizabeth Greensted
>>
>>                       Tel:  01904 328845
>>
>>                       Email: <mailto:liz.greensted at york.ac.uk>
>> liz.greensted at york.ac.uk < <mailto:liz.greensted at york.ac.uk>
>> mailto:liz.greensted at york.ac.uk>
>>
>>
>>
>>                       Centre Email: <mailto:cii at york.ac.uk>
>> cii at york.ac.uk < <mailto:cii at york.ac.uk> mailto:cii at york.ac.uk>
>>
>>
>>
>>                       Centre website: <http://www.york.ac.uk/cii>
>> http://www.york.ac.uk/cii
>>
>>
>>
>>                       Times Higher Education University of the Year
>> 2010
>>
>>
>>
>>                       Email disclaimer:
>> <http://www.york.ac.uk/docs/disclaimer/email.htm>
>> http://www.york.ac.uk/docs/disclaimer/email.htm
>>
>>
>>
>>
>>
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>>
>>
>>               ------------------------------
>>
>>
>>
>>               _______________________________________________
>>
>>               Leish-l mailing list
>>
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>> Leish-l at lineu.icb.usp.br
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>> http://lineu.icb.usp.br/cgi-bin/mailman/listinfo/leish-l
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>>
>>
>>
>>
>>               End of Leish-l Digest, Vol 44, Issue 3
>>
>>               **************************************
>>
>>
>>
>>
>>
>>
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