[Leish-l] RES: testing vaccinated dogs for immunopotentiation

[Chang, Kwang-Poo]

What Jenni said indicates that transplacental transmission of canine
leishmaniasis has some implication in considering dog vaccination.

 

Of further interest is the question of whether this transplacental
transmission could also occur in other reservoir animals or even in
human leishmaniasis ? I recall the description of such transmission in
human cases in some very early literature, but that has been always
considered as unlikely or extremely rare, more as a hypothesis than
reality. This issue may have been addressed in more recent
epidemiological studies of VL familial clustering in well-established
endemic sites ? Congenital transmission might escape our attention,
should the outcome be largely asymptomatic ?

 

KP

 

________________________________

From: Jennie Blackwell [mailto:jmb37 at cam.ac.uk] 
Sent: Wednesday, October 05, 2011 6:46 PM
To: Chang, Kwang-Poo
Cc: Petersen, Christine A [V PTH]; TECSA - Luiz Ristow; John David;
leish-l at lineu.icb.usp.br
Subject: Re: [Leish-l] RES: testing vaccinated dogs for
immunopotentiation

 

I doubt it. Treatment might but if the mum was already infected and
passed the parasite to the foetus I don't see how a vaccine would work
to clear the parasite from the foetus!

 

Slightly different question as to whether vaccinating mums will give
them sufficient protection to not pass the parasite to the pup in utero
should they get infected themselves after vaccination.

 

Cheers all, Jennie

Jenefer M. Blackwell

TICHR, CCHR, UWA

Phone: +61 8 94897910