[Leish-l] inquiry

[John David]

KP

The untreated lesion went away twice in our Brazil trial and once in  
the preliminary study in Afghanistan.  This should be looked at in a  
more definitive study with  patients that have  several lesions.

John David


On Jun 8, 2011, at 5:47 PM, Chang, Kwang-Poo wrote:

> Dear Alan,
>
> Most valuable information !
>
> I read from John's article, that untreated lesions also disappeared
> after thermotherapy of a single one ?
>
> Please respond with your experience. This is an important issue.
>
> KP
>
> -----Original Message-----
> From: Magill, Alan J COL MIL USA MEDCOM WRAIR
> [mailto:ALAN.MAGILL at US.ARMY.MIL]
> Sent: Wednesday, June 08, 2011 2:45 PM
> To: Chang, Kwang-Poo; John David
> Cc: Satoskar, Abhay; vishwamohan_katoch at yahoo.co.in; Raj;
> leish-l at lineu.icb.usp.br
> Subject: RE: [Leish-l] inquiry
>
> John certainly knows well..
>
> 50C is not tolerable to human skin. All potential lesions to be  
> treated
> need to be appropriately cleaned and anesthetized with intradermal and
> subQ injection of lidocaine. I have never tried the newer lidocaine
> creams such as EMLA, they might work as well. This can be somewhat  
> rate
> limiting for multiple lesions as each lesion needs to be prepared,
> injected, and you need to wait about 10 plus minutes for the lidocaine
> to work.
>
> Trying the Thermomed device on normal skin (try on yourself) will show
> that most people can only get to about 43 or 44 C before quickly
> removing the device from their skin.
>
> Alan Magill
>
>
> ________________________________
> From: leish-l-bounces at lineu.icb.usp.br
> [leish-l-bounces at lineu.icb.usp.br] On Behalf Of Chang, Kwang-Poo
> [KwangPoo.Chang at rosalindfranklin.edu]
> Sent: Monday, June 06, 2011 12:02 PM
> To: John David
> Cc: Satoskar, Abhay; vishwamohan_katoch at yahoo.co.in; Raj;
> leish-l at lineu.icb.usp.br
> Subject: Re: [Leish-l] inquiry
>
> Any chance to make it available for additional trials elsewhere ?
>
> I recall your statement in our conversation about the advantage of  
> this
> instrument over the heating lamp. That is to maintain the specific
> elevated temperature uniformly throughout the skin lesion for a
> sustained period. The 50 C must be the effective temperature that has
> been experimentally determined. It seems to be a tolerable temperature
> to human skin ?  Dr. Sharma may comment on this medically as a
> dermatologist ?
>
> KP
>
> ________________________________
> From: John David [mailto:jdavid at hsph.harvard.edu]
> Sent: Sunday, June 05, 2011 11:18 PM
> To: Chang, Kwang-Poo
> Cc: Sharmanl; Satoskar, Abhay; Raj; Petr Volf; leish-l at lineu.icb.usp.br 
> ;
> hgoto at usp.br; elfadil_abass at yahoo.com; vishwamohan_katoch at yahoo.co.in
> Subject: Re: [Leish-l] inquiry
>
> The Themomed instrument shown below can produce accurate 50 degrees C
> plus or minus 0.2 degrees temperature by radio wave.
> from Themorsurgery Technologies. Picture below.
> Two papers of a trial in Brazil and one in Afghanistan on CL below.
>