From allc48 at hotmail.com  Sun Jun  6 22:22:00 2010
From: allc48 at hotmail.com (Alejandro Llanos-Cuentas)
Date: Mon, 7 Jun 2010 01:22:00 +0000
Subject: [Leish-l] name
In-Reply-To: <SNT129-DS18577DC26C7322A7BFE9DFA8FE0@phx.gbl>
References: <599870.59349.qm@web7602.mail.in.yahoo.com>,
	<SNT129-DS18577DC26C7322A7BFE9DFA8FE0@phx.gbl>
Message-ID: <BAY154-w653730E4526058D3694472C1D50@phx.gbl>


Dear Sundar,

 

The primary reservoirs of Leishmania peruviana are mammals mainly small rodents, Phillotis andinum, Akodon sp, Didelphis albiventris (Llanos-Cuentas EA., Roncal N., Villaseca P., Paz L., Ogusuku E., P?rez JE., C?ceres A., Davies CR.  Natural infections of Leishmania peruviana in animals in the Peruvian Andes. Transactions of the Tropical Medicine and Hygiene, 93: 15 ? 20, 1999). The dogs are secondary reservoirs and their role is still not well understood (Reithinger R.,  Canales-Espinoza J., Llanos - Cuentas A., and Davis C. Domestic dog ownership: a risk factor for human infection with Leishmania (Viannia) species. Transactions of the Royal Society of Tropical Medicine and Hygiene, 97: 141-145, 2003).  The rate of cure of one schedule of Sb5+ is 71% similar to L.braziliensis (69%) and quite different to L.guyanensis (92%) in Peru. The mucosal involvement of L.peruviana is rare and usually by contiguity mechanism, very different to L.brazilinesis.
 

Best regards

 

 

Alejandro


 


From: drshyamsundar at hotmail.com
To: leish-l at lineu.icb.usp.br
Date: Sat, 15 May 2010 18:43:35 +0530
Subject: Re: [Leish-l] name


 
Is this statement about L peruviana  correct ?
L. (V.) peruviana has adpated to dogs, bringing infection into villages. 		 	   		  
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From fred.opperdoes at uclouvain.be  Sun Jun 13 13:31:49 2010
From: fred.opperdoes at uclouvain.be (fred opperdoes)
Date: Sun, 13 Jun 2010 18:31:49 +0200
Subject: [Leish-l] Fwd:Leishmaniasis, human - Spain
Message-ID: <3E58C10C-9D6D-4256-9DEA-6931B4AE569C@uclouvain.be>

> Date: Sat, 12 Jun 2010 13:37:18 -0400 (EDT)
> From: ProMED-mail <promed-ahead-edr at promed.isid.harvard.edu>
> Subject: PRO/AH/EDR> Leishmaniasis, human - Spain
> 
> LEISHMANIASIS, HUMAN - SPAIN
> ****************************
> A statement by ProMED-mail
> <http://www.promedmail.org>
> ProMED-mail is a program
> International Society for Infectious Diseases
> <http://www.isid.org>
> 
> Date: 10 Jun 2010
> Source: Lukoran, Spain [in Spanish, trans. Corr.SB, edited]
> <http://www.lukor.com/ciencia/noticias/1006/09162234.htm>
> 
> 
> Leishmaniasis is increasing in Spain
> - ------------------------------------
> Between 20 and 80 people each year suffer from a severe infection of  
> leishmaniasis, a disease that is transmitted from animal -- mostly  
> dogs -- to humans, causing fever and swollen liver and spleen and is  
> fatal in up to 5 percent of cases experts said this Wednesday at the  
> Infectopatolog?a Course II, held this week in Madrid.
> 
> As explained by the representative of the Center for Infectious  
> Diseases and International Health in Malaga and co-coordinator of the  
> conference, Dr. Fernando Farinas, this disease has become in recent  
> years on a "forgotten disease" despite the sandfly which transmits it  
> being endemic in Spain and infecting 5 of every hundred dogs per year  
> (possibly more).
> 
> Leishmaniasis is a zoonotic disease -- a condition shared by dogs and  
> humans, not transmitted by direct contact between man and animal but  
> through insect vectors which become infected after biting the main  
> reservoir of the parasite, the dog.
> 
> On the human side, leishmaniasis is particularly virulent in  
> immunocompromised patients (HIV, cancer or malnutrition mainly) and  
> may occur in 2 forms: the visceral, more serious and the cutaneous,  
> more benign and prevalent, that manifests itself through skin ulcers,  
> which are often confused with psoriasis.
> 
> The latter option is worryingly under-diagnosed in Spain, says Dr  
> Farinas, something that is making it easier for parasites to develop  
> "hyper-resistance" to the drugs most commonly used against them.  
> However, Spain has effective new medicines to eliminate these  
> pathogens [but see comment below].
> 
> This infectious disease specialist has said you cannot neglect the  
> research side of this disease, "it has been detected in patients with  
> HIV [infection] when the human is both reservoir and victim, without  
> the dog."
> 
> An extended illness all over Spain
> - ----------------------------------
> Regarding the incidence of canine leishmaniasis, regions in Spain most  
> affected so far are Andalusia, Palme Mallorca, Valencia and Catalonia.  
> However, in recent years it has been shown that not only the typical  
> Mediterranean climate zones are prone to the disease. According to the  
> latest data, areas of northern Spain are registering more and more  
> cases of dogs affected by leishmaniasis. In the Basque Country,  
> Galicia and Madrid, infections in dogs have increased 50 percent in  
> the last 15 years.
> 
> The head of the Department of Parasitology and Parasitic Diseases of  
> the Universidad Complutense de Madrid, Guadalupe Miro, stressed that  
> "only 5 percent of dogs are diagnosed with this disease, when in fact  
> about 60 percent are infected.
> 
> - --
> Communicated by:
> ProMED-mail
> <promed at promedmail.org>
> 
> [Leishmaniasis is endemic in Spain with dogs as the main reservoir, as  
> is also the case in Portugal, southern France, Italy, Malta and  
> Greece. A special concern is the association between clinical  
> leishmaniasis and immunosuppression e.g. HIV-infection or organ  
> transplants. A recent review reported more than 2000 such cases from  
> southern Europe over the past 10 years (Alvar J et al. The  
> relationship between leishmaniasis and AIDS: the second 10 years. Clin  
> Microbiol Rev. 2008;21:334-59). The role of dogs as reservoir in Spain  
> has also recently been reviewed (Miro G et al. Canine  
> leishmaniasis--new concepts and insights on an expanding zoonosis:  
> part two. Trends Parasitol. 2008;24:371-7).
> 
> Clearly, leishmaniasis is a increasing zoonotic infection in southern  
> Europe, which must be considered in cases with unexplained cutaneous  
> symptoms, long term low grade fever, weight loss and splenomegaly. -  
> Mod.EP]
> 
> ["[The disease is] under-diagnosed in Spain ... something that is  
> making it easier for parasites to develop "hyper-resistance" to the  
> drugs most commonly used against them" seems to be a non sequitur. If  
> the disease is not being diagnosed, it is not being treated with  
> specific drugs (pentavalent antimonials, pentamidine) therefore cannot  
> develop resistance to them. - Mod.JW]
> 
> [see also:
> 2009
> - ----
> Leishmaniasis - UK: imported 20091125.4049
> 2004
> - ----
> Leishmaniasis, dog reservoir - Spain 20040524.1388
> 2000
> - ----
> Leishmaniasis - Germany ex Spain 20000725.1236
> 1999
> - ----
> Leishmaniasis, visceral & HIV - Europe (SW) 19991106095248
> Leishmaniasis, visceral & HIV - Europe (SW) (03) 19991118221651
> 1997
> - ----
> Leishmaniasis, canine - Italy (02) 970411151032]
> ...................sb/ep/ejp/jw
> 
> ------------------------------
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From jayusp at hotmail.com  Sun Jun 13 23:01:35 2010
From: jayusp at hotmail.com (jeffrey shaw)
Date: Mon, 14 Jun 2010 02:01:35 +0000
Subject: [Leish-l] FW:  Fwd:Leishmaniasis, human - Spain
In-Reply-To: <3E58C10C-9D6D-4256-9DEA-6931B4AE569C@uclouvain.be>
References: <3E58C10C-9D6D-4256-9DEA-6931B4AE569C@uclouvain.be>
Message-ID: <BLU120-W244FA2FF45FC2937324FFBCBDC0@phx.gbl>



From: fred.opperdoes at uclouvain.be
Date: Sun, 13 Jun 2010 18:31:49 +0200
To: Leish-l at lineu.icb.usp.br
Subject: [Leish-l] Fwd:Leishmaniasis, human - Spain



Date: Sat, 12 Jun 2010 13:37:18 -0400 (EDT)
From: ProMED-mail <promed-ahead-edr at promed.isid.harvard.edu>
Subject: PRO/AH/EDR> Leishmaniasis, human - Spain

LEISHMANIASIS, HUMAN - SPAIN
****************************
A statement by ProMED-mail
<http://www.promedmail.org>
ProMED-mail is a program
International Society for Infectious Diseases
<http://www.isid.org>

Date: 10 Jun 2010
Source: Lukoran, Spain [in Spanish, trans. Corr.SB, edited]
<http://www.lukor.com/ciencia/noticias/1006/09162234.htm>


Leishmaniasis is increasing in Spain
- ------------------------------------
Between 20 and 80 people each year suffer from a severe infection of  
leishmaniasis, a disease that is transmitted from animal -- mostly  
dogs -- to humans, causing fever and swollen liver and spleen and is  
fatal in up to 5 percent of cases experts said this Wednesday at the  
Infectopatolog?a Course II, held this week in Madrid.

As explained by the representative of the Center for Infectious  
Diseases and International Health in Malaga and co-coordinator of the  
conference, Dr. Fernando Farinas, this disease has become in recent  
years on a "forgotten disease" despite the sandfly which transmits it  
being endemic in Spain and infecting 5 of every hundred dogs per year  
(possibly more).

Leishmaniasis is a zoonotic disease -- a condition shared by dogs and  
humans, not transmitted by direct contact between man and animal but  
through insect vectors which become infected after biting the main  
reservoir of the parasite, the dog.

On the human side, leishmaniasis is particularly virulent in  
immunocompromised patients (HIV, cancer or malnutrition mainly) and  
may occur in 2 forms: the visceral, more serious and the cutaneous,  
more benign and prevalent, that manifests itself through skin ulcers,  
which are often confused with psoriasis.

The latter option is worryingly under-diagnosed in Spain, says Dr  
Farinas, something that is making it easier for parasites to develop  
"hyper-resistance" to the drugs most commonly used against them.  
However, Spain has effective new medicines to eliminate these  
pathogens [but see comment below].

This infectious disease specialist has said you cannot neglect the  
research side of this disease, "it has been detected in patients with  
HIV [infection] when the human is both reservoir and victim, without  
the dog."

An extended illness all over Spain
- ----------------------------------
Regarding the incidence of canine leishmaniasis, regions in Spain most  
affected so far are Andalusia, Palme Mallorca, Valencia and Catalonia.  
However, in recent years it has been shown that not only the typical  
Mediterranean climate zones are prone to the disease. According to the  
latest data, areas of northern Spain are registering more and more  
cases of dogs affected by leishmaniasis. In the Basque Country,  
Galicia and Madrid, infections in dogs have increased 50 percent in  
the last 15 years.

The head of the Department of Parasitology and Parasitic Diseases of  
the Universidad Complutense de Madrid, Guadalupe Miro, stressed that  
"only 5 percent of dogs are diagnosed with this disease, when in fact  
about 60 percent are infected.

- --
Communicated by:
ProMED-mail
<promed at promedmail.org>

[Leishmaniasis is endemic in Spain with dogs as the main reservoir, as  
is also the case in Portugal, southern France, Italy, Malta and  
Greece. A special concern is the association between clinical  
leishmaniasis and immunosuppression e.g. HIV-infection or organ  
transplants. A recent review reported more than 2000 such cases from  
southern Europe over the past 10 years (Alvar J et al. The  
relationship between leishmaniasis and AIDS: the second 10 years. Clin  
Microbiol Rev. 2008;21:334-59). The role of dogs as reservoir in Spain  
has also recently been reviewed (Miro G et al. Canine  
leishmaniasis--new concepts and insights on an expanding zoonosis:  
part two. Trends Parasitol. 2008;24:371-7).

Clearly, leishmaniasis is a increasing zoonotic infection in southern  
Europe, which must be considered in cases with unexplained cutaneous  
symptoms, long term low grade fever, weight loss and splenomegaly. -  
Mod.EP]

["[The disease is] under-diagnosed in Spain ... something that is  
making it easier for parasites to develop "hyper-resistance" to the  
drugs most commonly used against them" seems to be a non sequitur. If  
the disease is not being diagnosed, it is not being treated with  
specific drugs (pentavalent antimonials, pentamidine) therefore cannot  
develop resistance to them. - Mod.JW]

[see also:
2009
- ----
Leishmaniasis - UK: imported 20091125.4049
2004
- ----
Leishmaniasis, dog reservoir - Spain 20040524.1388
2000
- ----
Leishmaniasis - Germany ex Spain 20000725.1236
1999
- ----
Leishmaniasis, visceral & HIV - Europe (SW) 19991106095248
Leishmaniasis, visceral & HIV - Europe (SW) (03) 19991118221651
1997
- ----
Leishmaniasis, canine - Italy (02) 970411151032]
...................sb/ep/ejp/jw

------------------------------
 		 	   		  
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From fred.opperdoes at uclouvain.be  Wed Jun 16 06:42:50 2010
From: fred.opperdoes at uclouvain.be (fred opperdoes)
Date: Wed, 16 Jun 2010 11:42:50 +0200
Subject: [Leish-l] Post-doc position in metabolomics available at the
	Antwerp Tropical institute
Message-ID: <436EE6F6-CC20-443A-BE80-902DA2AD4638@uclouvain.be>

Post-doctoral position in metabolomics of leishmania available at the Tropical institute in Antwerp, Belgium. see #BMB Blog http://bit.ly/dzqHHd

Fred R. Opperdoes,       	       	       	    

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From JCDujardin at itg.be  Wed Jun 16 05:45:22 2010
From: JCDujardin at itg.be (J.-C. Dujardin)
Date: Wed, 16 Jun 2010 10:45:22 +0200
Subject: [Leish-l] post-doc metabolomics
Message-ID: <F9193CB33FE5C3499C994B9DB8A445B5AE935D@itgsrv014.itg.be>

Dear Sir, Madam, we offer a post-doc position in leishmania metabolomics.
Could you please disseminate this info to the members of leish-l? Thanks in
advance
Warm regards
JCDujardin

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