L. infantum chagasi genome

Thu Sep 7 15:18:18 BRT 2000

Dear Jeffrey,
My view is that sequencing the entire genome of another species of
Leishmania would be unreasonably expensive and not needed.  The completion
of the L. major genome sequence, its comparison with the genomes of T.
brucei and T. cruzi along with anticipated DNA microarray studied that
compare species of Leishmania will identify regions of high similarity and
differences among Leishmania species.  Such regions would be worth
sequencing.  The character and consequences of the differences among
Leishmania species is uncertain at this stage which also makes embarking on
a full genome sequencing effort unreasonable at this time.
Regards,
Ken Stuart

-----Original Message-----
From: leish-l at bdt.org.br [mailto:leish-l at bdt.org.br]On Behalf Of Jeffrey
Shaw
Sent: Tuesday, September 05, 2000 8:31 AM
To: Multiple recipients of list
Subject: L. infantum chagasi genome

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As you may know there is considerable interest and support in Brazil for 
genome studies and it has been suggested by some members of the Brazilian 
scientific community that a candidate parasite for sequencing could be L. 
(L.)infantum chagasi. Others, however, feel it would be wiser to finish L. 
(L.)major first and then use this to looking at different regions of the 
visceral parasite.

Views of subscribers on this would be appreciated

Jeffrey Shaw
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<html>
As you may know there is considerable interest and support in Brazil for
genome studies and it has been suggested by some members of the Brazilian
scientific community that a candidate parasite for sequencing could be
L. (L.)infantum chagasi. Others, however, feel it would be wiser
to finish L. (L.)major first and then use this to looking at
different regions of the visceral parasite. 
 
Views of subscribers on this would be appreciated 
 
Jeffrey Shaw</html>

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