VL USA cont

[Jaclamothe at aol.com]

Dans un courrier daté du 27/04/00 19:10:19 Paris, Madrid (heure d'été), 
Dquaka at cs.com a écrit :

>    Am I the only person that has a dog that has been successfully treated 
>  for Leishmaniasis? My dog contracted the disease sometime prior to the 
fall 
>  of 93. He was treated with Allopurinol - and is currently symptom free - 6 
>  and a half years later. Just wondering if he is an exception.

Since the use of allopurinol in maintainance treatment in dogs (10 to 15 
mg/kg tid or bid all life long or 1 week a  month) canine leismaniasis has a 
better prognosis. Roura, Sanchez an Ferrer have shown tha 50% of the dogs are 
pcr negative (bone marrow) after 6 months. Do they still harbour parasites in 
their skin? Perhaps no! In the past, vets treated again and again  with 
antimonials when dogs were relapsing. It has  certainly created some 
resistant strains that are responsible of primary resistance in humans in 
areas were  dogs are treated (i think that refusing to treat dogs or killing 
them is impossible). SInce some years  dogs are protected against infection 
and reinfections with collars impregnated with deltamethrin (scalibor®) or 
treated with pump spray containing permethrine (Duowin® and others) (it also 
reduces  the transmission of the disease ). I am  working about treatment of 
dogs with amphotericin b in lipid emulsion. The follow up of these dogs show 
that most of them are pcr negative (bone marrow) after a short cure. We are 
also studying what happens in  the skin.  Early diagnosis,   pcr in the 
follow up or in the diagnosis of the disease , treatment with allopurinol 
(Slappendel has shown that it works alone : 87%of the dogs are still alive 
after 6 years) , amphotericin B , use of repellents, with all these tools , a 
high percentage of dogs can be clinically or parasitologically cured  without 
nearly any risk for humans.




Jacques Lamothe
CLINIQUE VETERINAIRE
1, rond-point de la Roya                                                      
                         
F. 06510 CARROS 
jaclamothe at aol.com