drug responses

[col_jonathan_berman at WRSMTP-CCMAIL.ARMY.MIL]

Re: antimonial efficacy in vitro and in vivo:

Articles close at hand are:

1. Older review of preclinical data

Berman JD.  Experimental Chemotherapy of Leishmaniasis - a critical review. in  
            Leishmaniasis (Eds: Chang K-P, and Bray RS.).  pp 112-138. (1985).

Note however: 

Roberts and Rainey 1993.  antileishmanial activity of sodium stibogluconate 
fractions. Antimicrob Agent Chemother 37: 1842

2. Fairly recent review of clinical data: 

Herwaldt BL. Recommendations for treating leishmaniasis with sodium 
stibogluconate (Pentostam) and review of pertinent clinical studies. Am J Trop 
Med Hyg 46: 296-306 (1992).

Note also:  The preclinical  literature is difficult because there is no 
standard in vitro model and also no standard in vivo model.  Another 
complicating factor is that the efficacy of antimony in whatever model is 
employed can also be determined n the presence of immunomodulators. If you want 
to get into the literature in depth, you might do well to call me directly (301-
427-5305; digital pager: 301-369-5445).

                                            COL Berman






hello everyone,
I am writing because I have just started to do some work on drug
treatment of Visceral Leishmaniasis in humans. I am trying to find
some papers that look into the dose response killing rate of
antimonial drugs. The data can be either from vitro or vivo
experiments. I would be very greatful for any general information or
possible authors and papers.
Thanks alot, Peter.

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